Understanding how methodological aspects affect the release of trace metal(loid)s from urban dust in inhalation bioaccessibility tests

The bioaccessibility of metal(loid)s in ambient particulate matter (PM) has been recently used to represent the risk of inhalation exposure. Nevertheless, different methodological factors affect the bioaccessibility values; among these, the type and composition of surrogate biological fluids and the...

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Autores: Expósito Monar, Andrea|||0000-0002-5465-5913, Markiv, Bohdana|||0000-0002-0968-5988, Ruiz Azcona, Laura|||0000-0003-2213-2728, Santibáñez Margüello, Miguel|||0000-0003-2634-615X, Fernández Olmo, Ignacio|||0000-0001-6096-5160
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad de Cantabria (UC)
Repositorio:UCrea Repositorio Abierto de la Universidad de Cantabria
Idioma:inglés
OAI Identifier:oai:repositorio.unican.es:10902/20397
Acceso en línea:http://hdl.handle.net/10902/20397
Access Level:acceso abierto
Palabra clave:Inhalation bioaccessibility
Trace metal(loid)s
Synthetic body fluids
Urban dust
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spelling Understanding how methodological aspects affect the release of trace metal(loid)s from urban dust in inhalation bioaccessibility testsExpósito Monar, Andrea|||0000-0002-5465-5913Markiv, Bohdana|||0000-0002-0968-5988 Ruiz Azcona, Laura|||0000-0003-2213-2728Santibáñez Margüello, Miguel|||0000-0003-2634-615XFernández Olmo, Ignacio|||0000-0001-6096-5160Inhalation bioaccessibilityTrace metal(loid)sSynthetic body fluidsUrban dustThe bioaccessibility of metal(loid)s in ambient particulate matter (PM) has been recently used to represent the risk of inhalation exposure. Nevertheless, different methodological factors affect the bioaccessibility values; among these, the type and composition of surrogate biological fluids and the liquid to solid ratio have been revealed to be the most important. To better understand how these methodological aspects affect the bioaccessibility, a reference material corresponding to urban dust (SRM1648a) was contacted with synthetic biological fluids commonly used in the literature representing surrogate fluids that may interact with fine (Gamble's solutions, artificial lysosomal fluid (ALF)) and coarse particles (gastric fluid), for liquid to solid (L/S) ratios ranging from 500 to 20,000. Visual MINTEQ 3.1. was used to enhance the discussion on how the solubility of metals in the leaching solution depends on the composition of the simulated fluids and the speciation of metals. The results obtained indicate that a small change in the composition of Gamble's solution (the presence of glycine) may increase significantly the bioaccessibility at a L/S ratio of 5,000. The highest bioaccessibility of most of the studied metal(loid)s at a L/S ratio of 5,000 was found for ALF fluid. The study of the effect of the L/S ratio showed that metal(loid)s bioaccessibility in Gamble's fluid increased logarithmically with increasing L/S ratio, while it remained practically constant in ALF and gastric fluid. This different behavior is explained assuming that the leaching of metal(loid)s in Gamble's solution is solubility-controlled, while in ALF and gastric fluid is availability-controlled.This work was funded by the Spanish Ministry of Science, Innovation and Universities through the CTM2017-82636-R Project. Bohdana Markiv also thanks this Ministry for the PhD grant awarded, PRE2018-085152.ElsevierUniversidad de Cantabria20212021-03-01journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articlehttp://hdl.handle.net/10902/20397Chemosphere, 2021, 267, 129181reponame:UCrea Repositorio Abierto de la Universidad de Cantabriainstname:Universidad de Cantabria (UC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repositorio.unican.es:10902/203972026-06-02T12:39:31Z
dc.title.none.fl_str_mv Understanding how methodological aspects affect the release of trace metal(loid)s from urban dust in inhalation bioaccessibility tests
title Understanding how methodological aspects affect the release of trace metal(loid)s from urban dust in inhalation bioaccessibility tests
spellingShingle Understanding how methodological aspects affect the release of trace metal(loid)s from urban dust in inhalation bioaccessibility tests
Expósito Monar, Andrea|||0000-0002-5465-5913
Inhalation bioaccessibility
Trace metal(loid)s
Synthetic body fluids
Urban dust
title_short Understanding how methodological aspects affect the release of trace metal(loid)s from urban dust in inhalation bioaccessibility tests
title_full Understanding how methodological aspects affect the release of trace metal(loid)s from urban dust in inhalation bioaccessibility tests
title_fullStr Understanding how methodological aspects affect the release of trace metal(loid)s from urban dust in inhalation bioaccessibility tests
title_full_unstemmed Understanding how methodological aspects affect the release of trace metal(loid)s from urban dust in inhalation bioaccessibility tests
title_sort Understanding how methodological aspects affect the release of trace metal(loid)s from urban dust in inhalation bioaccessibility tests
dc.creator.none.fl_str_mv Expósito Monar, Andrea|||0000-0002-5465-5913
Markiv, Bohdana|||0000-0002-0968-5988
Ruiz Azcona, Laura|||0000-0003-2213-2728
Santibáñez Margüello, Miguel|||0000-0003-2634-615X
Fernández Olmo, Ignacio|||0000-0001-6096-5160
author Expósito Monar, Andrea|||0000-0002-5465-5913
author_facet Expósito Monar, Andrea|||0000-0002-5465-5913
Markiv, Bohdana|||0000-0002-0968-5988
Ruiz Azcona, Laura|||0000-0003-2213-2728
Santibáñez Margüello, Miguel|||0000-0003-2634-615X
Fernández Olmo, Ignacio|||0000-0001-6096-5160
author_role author
author2 Markiv, Bohdana|||0000-0002-0968-5988
Ruiz Azcona, Laura|||0000-0003-2213-2728
Santibáñez Margüello, Miguel|||0000-0003-2634-615X
Fernández Olmo, Ignacio|||0000-0001-6096-5160
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidad de Cantabria
dc.subject.none.fl_str_mv Inhalation bioaccessibility
Trace metal(loid)s
Synthetic body fluids
Urban dust
topic Inhalation bioaccessibility
Trace metal(loid)s
Synthetic body fluids
Urban dust
description The bioaccessibility of metal(loid)s in ambient particulate matter (PM) has been recently used to represent the risk of inhalation exposure. Nevertheless, different methodological factors affect the bioaccessibility values; among these, the type and composition of surrogate biological fluids and the liquid to solid ratio have been revealed to be the most important. To better understand how these methodological aspects affect the bioaccessibility, a reference material corresponding to urban dust (SRM1648a) was contacted with synthetic biological fluids commonly used in the literature representing surrogate fluids that may interact with fine (Gamble's solutions, artificial lysosomal fluid (ALF)) and coarse particles (gastric fluid), for liquid to solid (L/S) ratios ranging from 500 to 20,000. Visual MINTEQ 3.1. was used to enhance the discussion on how the solubility of metals in the leaching solution depends on the composition of the simulated fluids and the speciation of metals. The results obtained indicate that a small change in the composition of Gamble's solution (the presence of glycine) may increase significantly the bioaccessibility at a L/S ratio of 5,000. The highest bioaccessibility of most of the studied metal(loid)s at a L/S ratio of 5,000 was found for ALF fluid. The study of the effect of the L/S ratio showed that metal(loid)s bioaccessibility in Gamble's fluid increased logarithmically with increasing L/S ratio, while it remained practically constant in ALF and gastric fluid. This different behavior is explained assuming that the leaching of metal(loid)s in Gamble's solution is solubility-controlled, while in ALF and gastric fluid is availability-controlled.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-03-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10902/20397
url http://hdl.handle.net/10902/20397
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Chemosphere, 2021, 267, 129181
reponame:UCrea Repositorio Abierto de la Universidad de Cantabria
instname:Universidad de Cantabria (UC)
instname_str Universidad de Cantabria (UC)
reponame_str UCrea Repositorio Abierto de la Universidad de Cantabria
collection UCrea Repositorio Abierto de la Universidad de Cantabria
repository.name.fl_str_mv
repository.mail.fl_str_mv
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