Childhood cancer in small geographical areas and proximity to air-polluting industries

AIM: Pediatric cancer has been associated with exposure to certain environmental carcinogens. The purpose of this work is to analyse the relationship between environmental pollution and pediatric cancer risk. METHOD: We analysed all incidences of pediatric cancer (<15) diagnosed in a Spanish regi...

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Authors: Ortega-García, Juan A, López-Hernández, Fernando A, Cárceles-Álvarez, Alberto, Fuster-Soler, José L, Sotomayor, Diana I, Ramis, Rebeca
Format: article
Publication Date:2017
Country:España
Institution:Instituto de Salud Carlos III (ISCIII)
Repository:Repisalud
Language:English
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/6857
Online Access:http://hdl.handle.net/20.500.12105/6857
Access Level:Open access
Keyword:Adolescent
Air Pollutants
Child
Child, Preschool
Environmental Exposure
Humans
Incidence
Infant
Infant, Newborn
Neoplasms
Spain
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spelling Childhood cancer in small geographical areas and proximity to air-polluting industriesOrtega-García, Juan ALópez-Hernández, Fernando ACárceles-Álvarez, AlbertoFuster-Soler, José LSotomayor, Diana IRamis, RebecaAdolescentAir PollutantsChildChild, PreschoolEnvironmental ExposureHumansIncidenceInfantInfant, NewbornNeoplasmsSpainAIM: Pediatric cancer has been associated with exposure to certain environmental carcinogens. The purpose of this work is to analyse the relationship between environmental pollution and pediatric cancer risk. METHOD: We analysed all incidences of pediatric cancer (<15) diagnosed in a Spanish region during the period 1998-2015. The place of residence of each patient and the exact geographical coordinates of main industrial facilities was codified in order to analyse the spatial distribution of cases of cancer in relation to industrial areas. Focal tests and focused Scan methodology were used for the identification of high-incidence-rate spatial clusters around the main industrial pollution foci. RESULTS: The crude rate for the period was 148.0 cases per 1,000,0000 children. The incidence of pediatric cancer increased significantly along the period of study. With respect to spatial distribution, results showed significant high incidence around some industrial pollution foci group and the Scan methodology identify spatial clustering. We observe a global major incidence of non Hodgkin lymphomas (NHL) considering all foci, and high incidence of Sympathetic Nervous System Tumour (SNST) around Energy and Electric and organic and inorganic chemical industries foci group. In the analysis foci to foci, the focused Scan test identifies several significant spatial clusters. Particularly, three significant clusters were identified: the first of SNST was around energy-generating chemical industries (2 cases versus the expected 0.26), another of NHL was around residue-valorisation plants (5 cases versus the expected 0.91) and finally one cluster of Hodgkin lymphoma around building materials (3 cases versus the expected 2.2) CONCLUSION: Results suggest a possible association between proximity to certain industries and pediatric cancer risk. More evidences are necessary before establishing the relationship between industrial pollution and pediatric cancer incidence.ElsevierNational Institutes of Health (Estados Unidos)Ministerio de Economía y Competitividad (España)Fundación Séneca-Agencia de Ciencia y Tecnología de la Región de Murcia20182018-12-1420172017-03-0120172017-03-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.12105/6857reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivs 4.0 Internationalhttps://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/68572026-06-12T12:43:37Z
dc.title.none.fl_str_mv Childhood cancer in small geographical areas and proximity to air-polluting industries
title Childhood cancer in small geographical areas and proximity to air-polluting industries
spellingShingle Childhood cancer in small geographical areas and proximity to air-polluting industries
Ortega-García, Juan A
Adolescent
Air Pollutants
Child
Child, Preschool
Environmental Exposure
Humans
Incidence
Infant
Infant, Newborn
Neoplasms
Spain
title_short Childhood cancer in small geographical areas and proximity to air-polluting industries
title_full Childhood cancer in small geographical areas and proximity to air-polluting industries
title_fullStr Childhood cancer in small geographical areas and proximity to air-polluting industries
title_full_unstemmed Childhood cancer in small geographical areas and proximity to air-polluting industries
title_sort Childhood cancer in small geographical areas and proximity to air-polluting industries
dc.creator.none.fl_str_mv Ortega-García, Juan A
López-Hernández, Fernando A
Cárceles-Álvarez, Alberto
Fuster-Soler, José L
Sotomayor, Diana I
Ramis, Rebeca
author Ortega-García, Juan A
author_facet Ortega-García, Juan A
López-Hernández, Fernando A
Cárceles-Álvarez, Alberto
Fuster-Soler, José L
Sotomayor, Diana I
Ramis, Rebeca
author_role author
author2 López-Hernández, Fernando A
Cárceles-Álvarez, Alberto
Fuster-Soler, José L
Sotomayor, Diana I
Ramis, Rebeca
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv National Institutes of Health (Estados Unidos)
Ministerio de Economía y Competitividad (España)
Fundación Séneca-Agencia de Ciencia y Tecnología de la Región de Murcia
dc.subject.none.fl_str_mv Adolescent
Air Pollutants
Child
Child, Preschool
Environmental Exposure
Humans
Incidence
Infant
Infant, Newborn
Neoplasms
Spain
topic Adolescent
Air Pollutants
Child
Child, Preschool
Environmental Exposure
Humans
Incidence
Infant
Infant, Newborn
Neoplasms
Spain
description AIM: Pediatric cancer has been associated with exposure to certain environmental carcinogens. The purpose of this work is to analyse the relationship between environmental pollution and pediatric cancer risk. METHOD: We analysed all incidences of pediatric cancer (<15) diagnosed in a Spanish region during the period 1998-2015. The place of residence of each patient and the exact geographical coordinates of main industrial facilities was codified in order to analyse the spatial distribution of cases of cancer in relation to industrial areas. Focal tests and focused Scan methodology were used for the identification of high-incidence-rate spatial clusters around the main industrial pollution foci. RESULTS: The crude rate for the period was 148.0 cases per 1,000,0000 children. The incidence of pediatric cancer increased significantly along the period of study. With respect to spatial distribution, results showed significant high incidence around some industrial pollution foci group and the Scan methodology identify spatial clustering. We observe a global major incidence of non Hodgkin lymphomas (NHL) considering all foci, and high incidence of Sympathetic Nervous System Tumour (SNST) around Energy and Electric and organic and inorganic chemical industries foci group. In the analysis foci to foci, the focused Scan test identifies several significant spatial clusters. Particularly, three significant clusters were identified: the first of SNST was around energy-generating chemical industries (2 cases versus the expected 0.26), another of NHL was around residue-valorisation plants (5 cases versus the expected 0.91) and finally one cluster of Hodgkin lymphoma around building materials (3 cases versus the expected 2.2) CONCLUSION: Results suggest a possible association between proximity to certain industries and pediatric cancer risk. More evidences are necessary before establishing the relationship between industrial pollution and pediatric cancer incidence.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-03-01
2017
2017-03-01
2018
2018-12-14
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/6857
url http://hdl.handle.net/20.500.12105/6857
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivs 4.0 International
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivs 4.0 International
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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