Hyperbaric Oxygen Therapy Reduces Oxidative Stress and Inflammation, and Increases Growth Factors Favouring the Healing Process of Diabetic Wounds

Hyperbaric oxygen therapy (HBOT) is the clinical application of oxygen at pressures higher than atmospheric pressure. HBOT has been effectively used to manage diverse clinical pathologies, such as non-healing diabetic ulcers. The aim of the present study was to analyse the effects of HBOT on the pla...

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Authors: Capó Fiol, Xavier, Monserrat-Mesquida, Margalida, Quetglas-Llabrés, Magdalena, Batle, Juan M, Tur, Josep A, Pons, Antoni, Sureda Gomila, Antoni, Tejada Gavela, Silvia
Format: article
Publication Date:2023
Country:España
Institution:Instituto de Salud Carlos III (ISCIII)
Repository:Repisalud
Language:English
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/23678
Online Access:https://hdl.handle.net/20.500.12105/23678
Access Level:Open access
Keyword:Diabetes Mellitus
Humanos
Biomarcadores
Oxigenación Hiperbárica
Inflamación
Estrés Oxidativo
Cicatrización de Heridas
Péptidos y Proteínas de Señalización Intercelular
Pie Diabético
Wound Healing
Diabetic Foot
Oxidative Stress
Biomarkers
Humans
Intercellular Signaling Peptides and Proteins
Inflammation
Hyperbaric Oxygenation
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spelling Hyperbaric Oxygen Therapy Reduces Oxidative Stress and Inflammation, and Increases Growth Factors Favouring the Healing Process of Diabetic WoundsCapó Fiol, XavierMonserrat-Mesquida, MargalidaQuetglas-Llabrés, MagdalenaBatle, Juan MTur, Josep APons, AntoniSureda Gomila, AntoniTejada Gavela, SilviaDiabetes MellitusHumanosBiomarcadoresOxigenación HiperbáricaInflamaciónEstrés OxidativoCicatrización de HeridasPéptidos y Proteínas de Señalización IntercelularPie DiabéticoWound HealingDiabetic FootOxidative StressBiomarkersDiabetes MellitusHumansIntercellular Signaling Peptides and ProteinsInflammationHyperbaric OxygenationHyperbaric oxygen therapy (HBOT) is the clinical application of oxygen at pressures higher than atmospheric pressure. HBOT has been effectively used to manage diverse clinical pathologies, such as non-healing diabetic ulcers. The aim of the present study was to analyse the effects of HBOT on the plasma oxidative and inflammation biomarkers and growth factors in patients with chronic diabetic wounds. The participants received 20 HBOT sessions (five sessions/week), and blood samples were obtained at sessions 1, 5 and 20, before and 2 h after the HBOT. An additional (control) blood sample was collected 28 days after wound recovery. No significant differences were evident in haematological parameters, whereas the biochemical parameters progressively decreased, which was significant for creatine phosphokinase (CPK) and aspartate aminotransferase (AST). The pro-inflammatory mediators, tumour necrosis factor alpha (TNF-α) and interleukin 1β (IL-1β), progressively decreased throughout the treatments. Biomarkers of oxidative stress--plasma protein levels of catalase, extracellular superoxide dismutase, myeloperoxidase, xanthine oxidase, malondialdehyde (MDA) levels and protein carbonyls--were reduced in accordance with wound healing. Plasma levels of growth factors--platelet-derived growth factor (PDFG), transforming growth factor β (TGF-β) and hypoxia-inducible factor 1-alpha (HIF-1α)-- were increased as a consequence of HBOT and reduced 28 days after complete wound healing, whereas matrix metallopeptidase 9 (MMP9) progressively decreased with the HBOT. In conclusion, HBOT reduced oxidative and pro-inflammatory mediators, and may participate in activating healing, angiogenesis and vascular tone regulation by increasing the release of growth factors.Multidisciplinary Digital Publishing Institute (MDPI)20242024-10-0920232023-04-1120232023-04-11research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articlehttps://hdl.handle.net/20.500.12105/23678reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/236782026-06-12T12:43:37Z
dc.title.none.fl_str_mv Hyperbaric Oxygen Therapy Reduces Oxidative Stress and Inflammation, and Increases Growth Factors Favouring the Healing Process of Diabetic Wounds
title Hyperbaric Oxygen Therapy Reduces Oxidative Stress and Inflammation, and Increases Growth Factors Favouring the Healing Process of Diabetic Wounds
spellingShingle Hyperbaric Oxygen Therapy Reduces Oxidative Stress and Inflammation, and Increases Growth Factors Favouring the Healing Process of Diabetic Wounds
Capó Fiol, Xavier
Diabetes Mellitus
Humanos
Biomarcadores
Oxigenación Hiperbárica
Inflamación
Estrés Oxidativo
Cicatrización de Heridas
Péptidos y Proteínas de Señalización Intercelular
Pie Diabético
Wound Healing
Diabetic Foot
Oxidative Stress
Biomarkers
Diabetes Mellitus
Humans
Intercellular Signaling Peptides and Proteins
Inflammation
Hyperbaric Oxygenation
title_short Hyperbaric Oxygen Therapy Reduces Oxidative Stress and Inflammation, and Increases Growth Factors Favouring the Healing Process of Diabetic Wounds
title_full Hyperbaric Oxygen Therapy Reduces Oxidative Stress and Inflammation, and Increases Growth Factors Favouring the Healing Process of Diabetic Wounds
title_fullStr Hyperbaric Oxygen Therapy Reduces Oxidative Stress and Inflammation, and Increases Growth Factors Favouring the Healing Process of Diabetic Wounds
title_full_unstemmed Hyperbaric Oxygen Therapy Reduces Oxidative Stress and Inflammation, and Increases Growth Factors Favouring the Healing Process of Diabetic Wounds
title_sort Hyperbaric Oxygen Therapy Reduces Oxidative Stress and Inflammation, and Increases Growth Factors Favouring the Healing Process of Diabetic Wounds
dc.creator.none.fl_str_mv Capó Fiol, Xavier
Monserrat-Mesquida, Margalida
Quetglas-Llabrés, Magdalena
Batle, Juan M
Tur, Josep A
Pons, Antoni
Sureda Gomila, Antoni
Tejada Gavela, Silvia
author Capó Fiol, Xavier
author_facet Capó Fiol, Xavier
Monserrat-Mesquida, Margalida
Quetglas-Llabrés, Magdalena
Batle, Juan M
Tur, Josep A
Pons, Antoni
Sureda Gomila, Antoni
Tejada Gavela, Silvia
author_role author
author2 Monserrat-Mesquida, Margalida
Quetglas-Llabrés, Magdalena
Batle, Juan M
Tur, Josep A
Pons, Antoni
Sureda Gomila, Antoni
Tejada Gavela, Silvia
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Diabetes Mellitus
Humanos
Biomarcadores
Oxigenación Hiperbárica
Inflamación
Estrés Oxidativo
Cicatrización de Heridas
Péptidos y Proteínas de Señalización Intercelular
Pie Diabético
Wound Healing
Diabetic Foot
Oxidative Stress
Biomarkers
Diabetes Mellitus
Humans
Intercellular Signaling Peptides and Proteins
Inflammation
Hyperbaric Oxygenation
topic Diabetes Mellitus
Humanos
Biomarcadores
Oxigenación Hiperbárica
Inflamación
Estrés Oxidativo
Cicatrización de Heridas
Péptidos y Proteínas de Señalización Intercelular
Pie Diabético
Wound Healing
Diabetic Foot
Oxidative Stress
Biomarkers
Diabetes Mellitus
Humans
Intercellular Signaling Peptides and Proteins
Inflammation
Hyperbaric Oxygenation
description Hyperbaric oxygen therapy (HBOT) is the clinical application of oxygen at pressures higher than atmospheric pressure. HBOT has been effectively used to manage diverse clinical pathologies, such as non-healing diabetic ulcers. The aim of the present study was to analyse the effects of HBOT on the plasma oxidative and inflammation biomarkers and growth factors in patients with chronic diabetic wounds. The participants received 20 HBOT sessions (five sessions/week), and blood samples were obtained at sessions 1, 5 and 20, before and 2 h after the HBOT. An additional (control) blood sample was collected 28 days after wound recovery. No significant differences were evident in haematological parameters, whereas the biochemical parameters progressively decreased, which was significant for creatine phosphokinase (CPK) and aspartate aminotransferase (AST). The pro-inflammatory mediators, tumour necrosis factor alpha (TNF-α) and interleukin 1β (IL-1β), progressively decreased throughout the treatments. Biomarkers of oxidative stress--plasma protein levels of catalase, extracellular superoxide dismutase, myeloperoxidase, xanthine oxidase, malondialdehyde (MDA) levels and protein carbonyls--were reduced in accordance with wound healing. Plasma levels of growth factors--platelet-derived growth factor (PDFG), transforming growth factor β (TGF-β) and hypoxia-inducible factor 1-alpha (HIF-1α)-- were increased as a consequence of HBOT and reduced 28 days after complete wound healing, whereas matrix metallopeptidase 9 (MMP9) progressively decreased with the HBOT. In conclusion, HBOT reduced oxidative and pro-inflammatory mediators, and may participate in activating healing, angiogenesis and vascular tone regulation by increasing the release of growth factors.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-04-11
2023
2023-04-11
2024
2024-10-09
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.12105/23678
url https://hdl.handle.net/20.500.12105/23678
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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