Anti-inflammatory and neuroprotective evaluation of diverse microalgae extracts enriched in carotenoids

Microalgae represent one of the most promising sources of bioactive compounds for the pharmaceutical and food industries. Among these bioactives, carotenoids could be highlighted due to their health-promoting effects, including anti-inflammatory, neuroprotective or antioxidant properties. In this st...

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Authors: Gallego, Rocío, Valdés, Alberto, Suárez Montenegro, Zully J., Sánchez-Martínez, J. David, Cifuentes, Alejandro, Ibáñez, Elena, Herrero, Miguel
Format: article
Status:Published version
Publication Date:2022
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/285054
Online Access:http://hdl.handle.net/10261/285054
Access Level:Open access
Keyword:Alzheimer's disease
Carotenoids
Cytotoxicity
Microalgae
Neuroprotection
Pressurized liquids extraction
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spelling Anti-inflammatory and neuroprotective evaluation of diverse microalgae extracts enriched in carotenoidsGallego, RocíoValdés, AlbertoSuárez Montenegro, Zully J.Sánchez-Martínez, J. DavidCifuentes, AlejandroIbáñez, ElenaHerrero, MiguelAlzheimer's diseaseCarotenoidsCytotoxicityMicroalgaeNeuroprotectionPressurized liquids extractionMicroalgae represent one of the most promising sources of bioactive compounds for the pharmaceutical and food industries. Among these bioactives, carotenoids could be highlighted due to their health-promoting effects, including anti-inflammatory, neuroprotective or antioxidant properties. In this study, diverse microalgae extracts enriched in carotenoids, including extracts from Haematococcus pluvialis, Nannochloropsis oceanica, Tisochrysis lutea and Porphyridium cruentum, were evaluated through a battery of in vitro neuroprotective assays in an effort to estimate their potential against neurological disorders. Results indicated that microalgae extracts exerted a moderate and selective cholinesterase inhibitory potential, as well as high antioxidant and anti-inflammatory capacities, highlighting N. oceanica and T. lutea extracts. In parallel, cytotoxicity tests and evaluation of the anti-inflammatory capacity of the microalgae extracts were performed using different models. In this regard, N. oceanica extract showed the highest inhibition of pro-inflammatory cytokine release, indicating that this microalga extract could be the most promising neuroprotective agent.This work was supported by projects ABACUS (Algae for a Biomass Applied to the produCtion of added value compounds—funded by the Bio Based Industries Joint Undertaking under the European Union's Horizon 2020 research and innovation programme under grant agreement No 745668) and AGL2017-89417-R (MINECO, Spain). A.V. would like to acknowledge the Spanish Ministry of Science, Innovation and Universities for his “Juan de la Cierva” post-doctoral grant (IJC2018-037560-I). J.D.S-M. would like to acknowledge the Ministry of Education (Spain) for a FPU predoctoral grant FPU17/01876. Z.J.S.M. would like to acknowledge the University of Nariño (Colombia) for financial support.Peer reviewedElsevierEuropean CommissionMinisterio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)Ministerio de Educación (España)Universidad de NariñoConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202220222022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/285054reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/EC/H2020/745668info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2017-89417-Rinfo:eu-repo/grantAgreement/AEI//IJC2018-037560-Ihttps://doi.org/10.1016/j.algal.2022.102830Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2850542026-05-22T06:33:51Z
dc.title.none.fl_str_mv Anti-inflammatory and neuroprotective evaluation of diverse microalgae extracts enriched in carotenoids
title Anti-inflammatory and neuroprotective evaluation of diverse microalgae extracts enriched in carotenoids
spellingShingle Anti-inflammatory and neuroprotective evaluation of diverse microalgae extracts enriched in carotenoids
Gallego, Rocío
Alzheimer's disease
Carotenoids
Cytotoxicity
Microalgae
Neuroprotection
Pressurized liquids extraction
title_short Anti-inflammatory and neuroprotective evaluation of diverse microalgae extracts enriched in carotenoids
title_full Anti-inflammatory and neuroprotective evaluation of diverse microalgae extracts enriched in carotenoids
title_fullStr Anti-inflammatory and neuroprotective evaluation of diverse microalgae extracts enriched in carotenoids
title_full_unstemmed Anti-inflammatory and neuroprotective evaluation of diverse microalgae extracts enriched in carotenoids
title_sort Anti-inflammatory and neuroprotective evaluation of diverse microalgae extracts enriched in carotenoids
dc.creator.none.fl_str_mv Gallego, Rocío
Valdés, Alberto
Suárez Montenegro, Zully J.
Sánchez-Martínez, J. David
Cifuentes, Alejandro
Ibáñez, Elena
Herrero, Miguel
author Gallego, Rocío
author_facet Gallego, Rocío
Valdés, Alberto
Suárez Montenegro, Zully J.
Sánchez-Martínez, J. David
Cifuentes, Alejandro
Ibáñez, Elena
Herrero, Miguel
author_role author
author2 Valdés, Alberto
Suárez Montenegro, Zully J.
Sánchez-Martínez, J. David
Cifuentes, Alejandro
Ibáñez, Elena
Herrero, Miguel
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv European Commission
Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
Ministerio de Educación (España)
Universidad de Nariño
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Alzheimer's disease
Carotenoids
Cytotoxicity
Microalgae
Neuroprotection
Pressurized liquids extraction
topic Alzheimer's disease
Carotenoids
Cytotoxicity
Microalgae
Neuroprotection
Pressurized liquids extraction
description Microalgae represent one of the most promising sources of bioactive compounds for the pharmaceutical and food industries. Among these bioactives, carotenoids could be highlighted due to their health-promoting effects, including anti-inflammatory, neuroprotective or antioxidant properties. In this study, diverse microalgae extracts enriched in carotenoids, including extracts from Haematococcus pluvialis, Nannochloropsis oceanica, Tisochrysis lutea and Porphyridium cruentum, were evaluated through a battery of in vitro neuroprotective assays in an effort to estimate their potential against neurological disorders. Results indicated that microalgae extracts exerted a moderate and selective cholinesterase inhibitory potential, as well as high antioxidant and anti-inflammatory capacities, highlighting N. oceanica and T. lutea extracts. In parallel, cytotoxicity tests and evaluation of the anti-inflammatory capacity of the microalgae extracts were performed using different models. In this regard, N. oceanica extract showed the highest inhibition of pro-inflammatory cytokine release, indicating that this microalga extract could be the most promising neuroprotective agent.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/285054
url http://hdl.handle.net/10261/285054
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/EC/H2020/745668
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2017-89417-R
info:eu-repo/grantAgreement/AEI//IJC2018-037560-I
https://doi.org/10.1016/j.algal.2022.102830
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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