Association of lifestyle factors and inflammation with sarcopenic obesity: data from the PREDIMED‐Plus trial

Background: Sarcopenia is a progressive age-related skeletal muscle disorder associated with increased likelihood of adverse outcomes. Muscle wasting is often accompanied by an increase in body fat, leading to ‘sarcopenic obesity’. The aim of the present study was to analyse the association of lifes...

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Authors: Abete, Itziar, Konieczna, Jadwiga, Zulet, M. Angeles, Galmes Panades, Aina M., Ibero Baraibar, Idoia, Babio, Nancy, Estruch Riba, Ramon, Vidal i Cortada, Josep, Toledo Atucha, Estefanía, Razquin, Cristina, Bartolomé, Rafael, Díaz Lopez, Andrés, Fiol Sala, Miguel, Casas Rodríguez, Rosa M., Vera, Josep, Buil Cosiales, Pilar, Pintó Sala, Xavier, Corbella, Emili, Puy Portillo, Maria, Paz, José Antonio de, Martín Sánchez, Vicente, Daimiel, Lidia, Goday Arnó, Albert, Rosique Esteban, Núria, Salas Salvadó, Jordi, Romaguera, Dora, Martínez, J. Alfredo, 1957-, PREDIMED-Plus Investigators
Format: article
Status:Published version
Publication Date:2019
Country:España
Institution:Universidad de Barcelona
Repository:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/173606
Online Access:https://hdl.handle.net/2445/173606
Access Level:Open access
Keyword:Obesitat
Estils de vida
Inflamació
Obesity
Lifestyles
Inflammation
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spelling Association of lifestyle factors and inflammation with sarcopenic obesity: data from the PREDIMED‐Plus trialAbete, ItziarKonieczna, JadwigaZulet, M. AngelesGalmes Panades, Aina M.Ibero Baraibar, IdoiaBabio, NancyEstruch Riba, RamonVidal i Cortada, JosepToledo Atucha, EstefaníaRazquin, CristinaBartolomé, RafaelDíaz Lopez, AndrésFiol Sala, MiguelCasas Rodríguez, Rosa M.Vera, JosepBuil Cosiales, PilarPintó Sala, XavierCorbella, EmiliPuy Portillo, MariaPaz, José Antonio deMartín Sánchez, VicenteDaimiel, LidiaGoday Arnó, AlbertRosique Esteban, NúriaSalas Salvadó, JordiRomaguera, DoraMartínez, J. Alfredo, 1957-PREDIMED-Plus InvestigatorsObesitatEstils de vidaInflamacióObesityLifestylesInflammationBackground: Sarcopenia is a progressive age-related skeletal muscle disorder associated with increased likelihood of adverse outcomes. Muscle wasting is often accompanied by an increase in body fat, leading to ‘sarcopenic obesity’. The aim of the present study was to analyse the association of lifestyle variables such as diet, dietary components, physical activity (PA), body composition, and inflammatory markers, with the risk of sarcopenic obesity. Methods: A cross-sectional analysis based on baseline data from the PREDIMED-Plus study was performed. A total of 1535 participants (48% women) with overweight/obesity (body mass index: 32.5 ± 3.3 kg/m2; age: 65.2 ± 4.9 years old) and metabolic syndrome were categorized according to sex-specific tertiles (T) of the sarcopenic index (SI) as assessed by dual-energy X-ray absorptiometry scanning. Anthropometrical measurements, biochemical markers, dietary intake, and PA information were collected. Linear regression analyses were carried out to evaluate the association between variables. Results: Subjects in the first SI tertile were older, less physically active, showed higher frequency of abdominal obesity and diabetes, and consumed higher saturated fat and less vitamin C than subjects from the other two tertiles (all P < 0.05). Multiple adjusted linear regression models evidenced significant positive associations across tertiles of SI with adherence to the Mediterranean dietary score (P-trend < 0.05), PA (P-trend < 0.0001), and the 30 s chair stand test (P-trend < 0.0001), whereas significant negative associations were found with an inadequate vitamin C consumption (P-trend < 0.05), visceral fat and leucocyte count (all P-trend < 0.0001), and some white cell subtypes (neutrophils and monocytes), neutrophil-tolymphocyte ratio, and platelet count (all P-trend < 0.05). When models were additionally adjusted by potential mediators (inflammatory markers, diabetes, and waist circumference), no relevant changes were observed, only dietary variables lost significance.Wiley2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/173606Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1002/jcsm.12442Journal of Cachexia, Sarcopenia and Muscle, 2019, vol. 10, num. 5, p. 974-984https://doi.org/10.1002/jcsm.12442info:eu-repo/grantAgreement/EC/FP7/340918cc by-nc (c) Abete et al., 2020http://creativecommons.org/licenses/by-nc/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1736062026-05-27T06:46:51Z
dc.title.none.fl_str_mv Association of lifestyle factors and inflammation with sarcopenic obesity: data from the PREDIMED‐Plus trial
title Association of lifestyle factors and inflammation with sarcopenic obesity: data from the PREDIMED‐Plus trial
spellingShingle Association of lifestyle factors and inflammation with sarcopenic obesity: data from the PREDIMED‐Plus trial
Abete, Itziar
Obesitat
Estils de vida
Inflamació
Obesity
Lifestyles
Inflammation
title_short Association of lifestyle factors and inflammation with sarcopenic obesity: data from the PREDIMED‐Plus trial
title_full Association of lifestyle factors and inflammation with sarcopenic obesity: data from the PREDIMED‐Plus trial
title_fullStr Association of lifestyle factors and inflammation with sarcopenic obesity: data from the PREDIMED‐Plus trial
title_full_unstemmed Association of lifestyle factors and inflammation with sarcopenic obesity: data from the PREDIMED‐Plus trial
title_sort Association of lifestyle factors and inflammation with sarcopenic obesity: data from the PREDIMED‐Plus trial
dc.creator.none.fl_str_mv Abete, Itziar
Konieczna, Jadwiga
Zulet, M. Angeles
Galmes Panades, Aina M.
Ibero Baraibar, Idoia
Babio, Nancy
Estruch Riba, Ramon
Vidal i Cortada, Josep
Toledo Atucha, Estefanía
Razquin, Cristina
Bartolomé, Rafael
Díaz Lopez, Andrés
Fiol Sala, Miguel
Casas Rodríguez, Rosa M.
Vera, Josep
Buil Cosiales, Pilar
Pintó Sala, Xavier
Corbella, Emili
Puy Portillo, Maria
Paz, José Antonio de
Martín Sánchez, Vicente
Daimiel, Lidia
Goday Arnó, Albert
Rosique Esteban, Núria
Salas Salvadó, Jordi
Romaguera, Dora
Martínez, J. Alfredo, 1957-
PREDIMED-Plus Investigators
author Abete, Itziar
author_facet Abete, Itziar
Konieczna, Jadwiga
Zulet, M. Angeles
Galmes Panades, Aina M.
Ibero Baraibar, Idoia
Babio, Nancy
Estruch Riba, Ramon
Vidal i Cortada, Josep
Toledo Atucha, Estefanía
Razquin, Cristina
Bartolomé, Rafael
Díaz Lopez, Andrés
Fiol Sala, Miguel
Casas Rodríguez, Rosa M.
Vera, Josep
Buil Cosiales, Pilar
Pintó Sala, Xavier
Corbella, Emili
Puy Portillo, Maria
Paz, José Antonio de
Martín Sánchez, Vicente
Daimiel, Lidia
Goday Arnó, Albert
Rosique Esteban, Núria
Salas Salvadó, Jordi
Romaguera, Dora
Martínez, J. Alfredo, 1957-
PREDIMED-Plus Investigators
author_role author
author2 Konieczna, Jadwiga
Zulet, M. Angeles
Galmes Panades, Aina M.
Ibero Baraibar, Idoia
Babio, Nancy
Estruch Riba, Ramon
Vidal i Cortada, Josep
Toledo Atucha, Estefanía
Razquin, Cristina
Bartolomé, Rafael
Díaz Lopez, Andrés
Fiol Sala, Miguel
Casas Rodríguez, Rosa M.
Vera, Josep
Buil Cosiales, Pilar
Pintó Sala, Xavier
Corbella, Emili
Puy Portillo, Maria
Paz, José Antonio de
Martín Sánchez, Vicente
Daimiel, Lidia
Goday Arnó, Albert
Rosique Esteban, Núria
Salas Salvadó, Jordi
Romaguera, Dora
Martínez, J. Alfredo, 1957-
PREDIMED-Plus Investigators
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Obesitat
Estils de vida
Inflamació
Obesity
Lifestyles
Inflammation
topic Obesitat
Estils de vida
Inflamació
Obesity
Lifestyles
Inflammation
description Background: Sarcopenia is a progressive age-related skeletal muscle disorder associated with increased likelihood of adverse outcomes. Muscle wasting is often accompanied by an increase in body fat, leading to ‘sarcopenic obesity’. The aim of the present study was to analyse the association of lifestyle variables such as diet, dietary components, physical activity (PA), body composition, and inflammatory markers, with the risk of sarcopenic obesity. Methods: A cross-sectional analysis based on baseline data from the PREDIMED-Plus study was performed. A total of 1535 participants (48% women) with overweight/obesity (body mass index: 32.5 ± 3.3 kg/m2; age: 65.2 ± 4.9 years old) and metabolic syndrome were categorized according to sex-specific tertiles (T) of the sarcopenic index (SI) as assessed by dual-energy X-ray absorptiometry scanning. Anthropometrical measurements, biochemical markers, dietary intake, and PA information were collected. Linear regression analyses were carried out to evaluate the association between variables. Results: Subjects in the first SI tertile were older, less physically active, showed higher frequency of abdominal obesity and diabetes, and consumed higher saturated fat and less vitamin C than subjects from the other two tertiles (all P < 0.05). Multiple adjusted linear regression models evidenced significant positive associations across tertiles of SI with adherence to the Mediterranean dietary score (P-trend < 0.05), PA (P-trend < 0.0001), and the 30 s chair stand test (P-trend < 0.0001), whereas significant negative associations were found with an inadequate vitamin C consumption (P-trend < 0.05), visceral fat and leucocyte count (all P-trend < 0.0001), and some white cell subtypes (neutrophils and monocytes), neutrophil-tolymphocyte ratio, and platelet count (all P-trend < 0.05). When models were additionally adjusted by potential mediators (inflammatory markers, diabetes, and waist circumference), no relevant changes were observed, only dietary variables lost significance.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/173606
url https://hdl.handle.net/2445/173606
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1002/jcsm.12442
Journal of Cachexia, Sarcopenia and Muscle, 2019, vol. 10, num. 5, p. 974-984
https://doi.org/10.1002/jcsm.12442
info:eu-repo/grantAgreement/EC/FP7/340918
dc.rights.none.fl_str_mv cc by-nc (c) Abete et al., 2020
http://creativecommons.org/licenses/by-nc/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by-nc (c) Abete et al., 2020
http://creativecommons.org/licenses/by-nc/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869425199848357888
score 15,301629

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