Infective Endocarditis in Diabetic Patients: A Different Profile with Prognostic Consequences

Background. Infective Endocarditis (IE) is a severe condition. Diabetes mellitus (DM) has been associated with a poor prognosis in other settings. Our aim was to describe the profile and prognosis of IE with and without DM and to analyze the prognostic relevance of DM-related organ damage. Methods....

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Autores: Biezma, María Isabel, Muñoz, Patricia, Villa, Sofía de la, Fariñas-Álvarez, M. Carmen, Arnáiz de las Revillas, Francisco, Gutiérrez Carretero, Encarnación, Martínez-Sellés, Manuel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/139581
Acceso en línea:https://hdl.handle.net/11441/139581
https://doi.org/10.3390/jcm11092651
Access Level:acceso abierto
Palabra clave:Infective endocarditis
Diabetes mellitus
Prognosis
In-hospital mortality
One-year mortality
Organ damage
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spelling Infective Endocarditis in Diabetic Patients: A Different Profile with Prognostic ConsequencesBiezma, María IsabelMuñoz, PatriciaVilla, Sofía de laFariñas-Álvarez, M. CarmenArnáiz de las Revillas, FranciscoGutiérrez Carretero, EncarnaciónMartínez-Sellés, ManuelInfective endocarditisDiabetes mellitusPrognosisIn-hospital mortalityOne-year mortalityOrgan damageBackground. Infective Endocarditis (IE) is a severe condition. Diabetes mellitus (DM) has been associated with a poor prognosis in other settings. Our aim was to describe the profile and prognosis of IE with and without DM and to analyze the prognostic relevance of DM-related organ damage. Methods. Retrospective analysis of the Spanish IE Registry (2008–2020). Results. The cohort comprises 5590 IE patients with a mean age of 65.0 ± 15.5 years; 3764 (67.3%) were male. DM was found in 1625 patients (29.1%) and 515 presented DM-related organ damage. DM prevalence during the first half of the study period was 27.6% vs. 30.6% in the last half, p = 0.015. Patients with DM presented higher in-hospital mortality than those without DM (521 [32.1%] vs. 924 [23.3%], p < 0.001) and higher one-year mortality (640 [39.4%] vs. 1131 [28.5%], p < 0.001). Among DM patients, organ damage was associated with higher in-hospital (200 [38.8%] vs. 321 [28.9%], p < 0.001) and one-year mortality (247 [48.0%] vs. 393 [35.4%], p < 0.001). Multivariate analyses showed an independent association of DM with in-hospital (odds ratio [OR] = 1.34, 95% confidence interval [CI]: 1.16–1.55, p < 0.001) and one-year mortality (OR = 1.38, 95% CI: 1.21–1.59, p < 0.001). Among DM patients, organ damage was independently associated with higher in-hospital (OR = 1.37, 95% CI: 1.06–1.76, p = 0.015) and one-year mortality (OR = 1.59, 95% CI = 1.26–2.01, p < 0.001) Conclusions. The prevalence of DM among patients with IE is increasing and is already above 30%. DM is independently associated with a poor prognosis, particularly in the case of DM with organ damage.MDPICirugíaCTS200: Trasplante Corazón. Conservación Corazón Donante2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/139581https://doi.org/10.3390/jcm11092651reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésJournal of Clinical Medicine, 11 (9), 2651.https://www.mdpi.com/2077-0383/11/9/2651info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1395812026-06-17T12:51:07Z
dc.title.none.fl_str_mv Infective Endocarditis in Diabetic Patients: A Different Profile with Prognostic Consequences
title Infective Endocarditis in Diabetic Patients: A Different Profile with Prognostic Consequences
spellingShingle Infective Endocarditis in Diabetic Patients: A Different Profile with Prognostic Consequences
Biezma, María Isabel
Infective endocarditis
Diabetes mellitus
Prognosis
In-hospital mortality
One-year mortality
Organ damage
title_short Infective Endocarditis in Diabetic Patients: A Different Profile with Prognostic Consequences
title_full Infective Endocarditis in Diabetic Patients: A Different Profile with Prognostic Consequences
title_fullStr Infective Endocarditis in Diabetic Patients: A Different Profile with Prognostic Consequences
title_full_unstemmed Infective Endocarditis in Diabetic Patients: A Different Profile with Prognostic Consequences
title_sort Infective Endocarditis in Diabetic Patients: A Different Profile with Prognostic Consequences
dc.creator.none.fl_str_mv Biezma, María Isabel
Muñoz, Patricia
Villa, Sofía de la
Fariñas-Álvarez, M. Carmen
Arnáiz de las Revillas, Francisco
Gutiérrez Carretero, Encarnación
Martínez-Sellés, Manuel
author Biezma, María Isabel
author_facet Biezma, María Isabel
Muñoz, Patricia
Villa, Sofía de la
Fariñas-Álvarez, M. Carmen
Arnáiz de las Revillas, Francisco
Gutiérrez Carretero, Encarnación
Martínez-Sellés, Manuel
author_role author
author2 Muñoz, Patricia
Villa, Sofía de la
Fariñas-Álvarez, M. Carmen
Arnáiz de las Revillas, Francisco
Gutiérrez Carretero, Encarnación
Martínez-Sellés, Manuel
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Cirugía
CTS200: Trasplante Corazón. Conservación Corazón Donante
dc.subject.none.fl_str_mv Infective endocarditis
Diabetes mellitus
Prognosis
In-hospital mortality
One-year mortality
Organ damage
topic Infective endocarditis
Diabetes mellitus
Prognosis
In-hospital mortality
One-year mortality
Organ damage
description Background. Infective Endocarditis (IE) is a severe condition. Diabetes mellitus (DM) has been associated with a poor prognosis in other settings. Our aim was to describe the profile and prognosis of IE with and without DM and to analyze the prognostic relevance of DM-related organ damage. Methods. Retrospective analysis of the Spanish IE Registry (2008–2020). Results. The cohort comprises 5590 IE patients with a mean age of 65.0 ± 15.5 years; 3764 (67.3%) were male. DM was found in 1625 patients (29.1%) and 515 presented DM-related organ damage. DM prevalence during the first half of the study period was 27.6% vs. 30.6% in the last half, p = 0.015. Patients with DM presented higher in-hospital mortality than those without DM (521 [32.1%] vs. 924 [23.3%], p < 0.001) and higher one-year mortality (640 [39.4%] vs. 1131 [28.5%], p < 0.001). Among DM patients, organ damage was associated with higher in-hospital (200 [38.8%] vs. 321 [28.9%], p < 0.001) and one-year mortality (247 [48.0%] vs. 393 [35.4%], p < 0.001). Multivariate analyses showed an independent association of DM with in-hospital (odds ratio [OR] = 1.34, 95% confidence interval [CI]: 1.16–1.55, p < 0.001) and one-year mortality (OR = 1.38, 95% CI: 1.21–1.59, p < 0.001). Among DM patients, organ damage was independently associated with higher in-hospital (OR = 1.37, 95% CI: 1.06–1.76, p = 0.015) and one-year mortality (OR = 1.59, 95% CI = 1.26–2.01, p < 0.001) Conclusions. The prevalence of DM among patients with IE is increasing and is already above 30%. DM is independently associated with a poor prognosis, particularly in the case of DM with organ damage.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/139581
https://doi.org/10.3390/jcm11092651
url https://hdl.handle.net/11441/139581
https://doi.org/10.3390/jcm11092651
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Journal of Clinical Medicine, 11 (9), 2651.
https://www.mdpi.com/2077-0383/11/9/2651
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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