Intraocular injectable hydrogels for the delivery of cells and nanoparticles

The rising global life expectancy has led to a growing prevalence of ophthalmic diseases, while current treatments face important limitations in terms of efficacy, costs, and patient compliance. The use of injectable hydrogels as drug and cell carriers is a promising approach, compared to the inject...

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Detalles Bibliográficos
Autores: Ibeas Moreno, Elena, Alonso Fernández, María José, Abbadessa, Anna
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:minerva.usc.gal:10347/46018
Acceso en línea:https://hdl.handle.net/10347/46018
Access Level:acceso abierto
Palabra clave:Hydrogel
Injectable
Eye
Nanoparticle
Cells
Ocular regeneration
Ocular drug delivery
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spelling Intraocular injectable hydrogels for the delivery of cells and nanoparticlesIbeas Moreno, ElenaAlonso Fernández, María JoséAbbadessa, AnnaHydrogelInjectableEyeNanoparticleCellsOcular regenerationOcular drug deliveryThe rising global life expectancy has led to a growing prevalence of ophthalmic diseases, while current treatments face important limitations in terms of efficacy, costs, and patient compliance. The use of injectable hydrogels as drug and cell carriers is a promising approach, compared to the injection of drug solutions or cell suspensions. This is because the hydrogel matrix may offer protection against clearance or degradation, may modulate drug/cell release, and provide a biomimetic substrate for differentiating cells while being minimally invasive. On one hand, injectable hydrogels for ocular drug delivery have been traditionally designed to host and release small drugs or proteins. However, limitations such as high burst release and difficulty of entrapping hydrophobic molecules led to the emergence of nanocomposite hydrogels, where the drug is entrapped in nanoparticles prior hydrogel incorporation. Composite systems offer great advantages over the injection of particle suspensions, improving particle fate and drug release kinetics. On the other hand, injectable hydrogels offer a cell-friendly environment to seek tissue regeneration, providing biomechanical and biochemical cues for cellular cross-talk, differentiation, and formation of new extracellular matrix. This review critically discusses recent advancements in the development of novel injectable hydrogels as delivery vehicles for drug-loaded nanoparticles and cells, with a major focus on the formulation components, administration routes, and other factors affecting performance, highlighting promising aspects and challenges to address in the future.ElsevierUniversidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía FarmacéuticaUniversidade de Santiago de Compostela. Centro de Investigación en Medicina Molecular e Enfermidades Crónicas (CiMUS)20252025-04-1220252025-04-12journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10347/46018reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostelainstname:Universidad de Santiago de Compostela (USC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2© 2025 The Authors. Published by Elsevier Ltd.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:minerva.usc.gal:10347/460182026-06-15T12:47:27Z
dc.title.none.fl_str_mv Intraocular injectable hydrogels for the delivery of cells and nanoparticles
title Intraocular injectable hydrogels for the delivery of cells and nanoparticles
spellingShingle Intraocular injectable hydrogels for the delivery of cells and nanoparticles
Ibeas Moreno, Elena
Hydrogel
Injectable
Eye
Nanoparticle
Cells
Ocular regeneration
Ocular drug delivery
title_short Intraocular injectable hydrogels for the delivery of cells and nanoparticles
title_full Intraocular injectable hydrogels for the delivery of cells and nanoparticles
title_fullStr Intraocular injectable hydrogels for the delivery of cells and nanoparticles
title_full_unstemmed Intraocular injectable hydrogels for the delivery of cells and nanoparticles
title_sort Intraocular injectable hydrogels for the delivery of cells and nanoparticles
dc.creator.none.fl_str_mv Ibeas Moreno, Elena
Alonso Fernández, María José
Abbadessa, Anna
author Ibeas Moreno, Elena
author_facet Ibeas Moreno, Elena
Alonso Fernández, María José
Abbadessa, Anna
author_role author
author2 Alonso Fernández, María José
Abbadessa, Anna
author2_role author
author
dc.contributor.none.fl_str_mv Universidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica
Universidade de Santiago de Compostela. Centro de Investigación en Medicina Molecular e Enfermidades Crónicas (CiMUS)
dc.subject.none.fl_str_mv Hydrogel
Injectable
Eye
Nanoparticle
Cells
Ocular regeneration
Ocular drug delivery
topic Hydrogel
Injectable
Eye
Nanoparticle
Cells
Ocular regeneration
Ocular drug delivery
description The rising global life expectancy has led to a growing prevalence of ophthalmic diseases, while current treatments face important limitations in terms of efficacy, costs, and patient compliance. The use of injectable hydrogels as drug and cell carriers is a promising approach, compared to the injection of drug solutions or cell suspensions. This is because the hydrogel matrix may offer protection against clearance or degradation, may modulate drug/cell release, and provide a biomimetic substrate for differentiating cells while being minimally invasive. On one hand, injectable hydrogels for ocular drug delivery have been traditionally designed to host and release small drugs or proteins. However, limitations such as high burst release and difficulty of entrapping hydrophobic molecules led to the emergence of nanocomposite hydrogels, where the drug is entrapped in nanoparticles prior hydrogel incorporation. Composite systems offer great advantages over the injection of particle suspensions, improving particle fate and drug release kinetics. On the other hand, injectable hydrogels offer a cell-friendly environment to seek tissue regeneration, providing biomechanical and biochemical cues for cellular cross-talk, differentiation, and formation of new extracellular matrix. This review critically discusses recent advancements in the development of novel injectable hydrogels as delivery vehicles for drug-loaded nanoparticles and cells, with a major focus on the formulation components, administration routes, and other factors affecting performance, highlighting promising aspects and challenges to address in the future.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025-04-12
2025
2025-04-12
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10347/46018
url https://hdl.handle.net/10347/46018
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
© 2025 The Authors. Published by Elsevier Ltd.
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
© 2025 The Authors. Published by Elsevier Ltd.
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname:Universidad de Santiago de Compostela (USC)
instname_str Universidad de Santiago de Compostela (USC)
reponame_str Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
collection Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
repository.name.fl_str_mv
repository.mail.fl_str_mv
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