Bipolar disorder and antibodies against the N-methyl-d-aspartate receptor: A gate to the involvement of autoimmunity in the pathophysiology of bipolar illness.

The high prevalence of comorbidity between bipolar disorder (BD) and other medical conditions, including autoimmune diseases, supports the hypothesis of the nature of BD as a biological illness category. Hence, an immune dysregulation process may play an important role in the development of at least...

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Detalhes bibliográficos
Autores: León Caballero, Jordi, Pacchiarotti, Isabella, Murru, Andrea, Valentí, M., Colom, Francesc, Benach, B., Pérez Solà, Víctor, Dalmau, Josep, Vieta, Eduard
Formato: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2015
País:España
Recursos:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/25110
Acesso em linha:http://hdl.handle.net/10230/25110
http://dx.doi.org/10.1016/j.neubiorev.2015.05.012
Access Level:acceso abierto
Palavra-chave:Psicosi maniacodepressiva
Autoimmunitat
Depressió psíquica
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spelling Bipolar disorder and antibodies against the N-methyl-d-aspartate receptor: A gate to the involvement of autoimmunity in the pathophysiology of bipolar illness.León Caballero, JordiPacchiarotti, IsabellaMurru, AndreaValentí, M.Colom, FrancescBenach, B.Pérez Solà, VíctorDalmau, JosepVieta, EduardPsicosi maniacodepressivaAutoimmunitatDepressió psíquicaThe high prevalence of comorbidity between bipolar disorder (BD) and other medical conditions, including autoimmune diseases, supports the hypothesis of the nature of BD as a biological illness category. Hence, an immune dysregulation process may play an important role in the development of at least certain subtypes of BD. Increasing evidence also suggests that the N-methyl-d-aspartate receptor (NMDAR) may be relevant in the pathophysiology of BD. A possible key mechanism underlying the physiopathology of certain autoimmune diseases that may present with affective symptoms might be the production of anti-NMDAR auto-antibodies (auto-Abs). The best characterized autoimmune anti-NMDAR disease is the anti-NMDAR encephalitis. It has been found that 4% of these patients present isolated, mostly affective, psychiatric manifestations during their illness. An interesting suggestion emerged from this overview is that the same mechanisms that trigger affective symptoms in patients with increased anti-NMDAR auto-Abs levels could be involved in the physiopathology of at least a subgroup of BD. Future studies are needed to characterize the relationship between anti-NMDAR auto-Abs and BD.The authors ofthis report wouldlike to acknowledge the support of the Spanish Ministry of Economy and Competitiveness, Instituto de Salud Carlos III (CP08/00140 and PI 12/00910), CIBERSAM (Exp. CB07/ 09/0004), the Spanish Ministry of Education and the Comissionat per a Universitats i Recerca del DIUE de la Generalitat de Catalunya to the Bipolar Disorders Group (2014 SGR 398).Elsevier20152015info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/25110http://dx.doi.org/10.1016/j.neubiorev.2015.05.012reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésNeuroscience & Biobehavioral Reviews. 2015 Aug;55:403-12Copyright © 2015 Elsevier Ltd. All rights reserved.info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/251102026-06-12T07:21:37Z
dc.title.none.fl_str_mv Bipolar disorder and antibodies against the N-methyl-d-aspartate receptor: A gate to the involvement of autoimmunity in the pathophysiology of bipolar illness.
title Bipolar disorder and antibodies against the N-methyl-d-aspartate receptor: A gate to the involvement of autoimmunity in the pathophysiology of bipolar illness.
spellingShingle Bipolar disorder and antibodies against the N-methyl-d-aspartate receptor: A gate to the involvement of autoimmunity in the pathophysiology of bipolar illness.
León Caballero, Jordi
Psicosi maniacodepressiva
Autoimmunitat
Depressió psíquica
title_short Bipolar disorder and antibodies against the N-methyl-d-aspartate receptor: A gate to the involvement of autoimmunity in the pathophysiology of bipolar illness.
title_full Bipolar disorder and antibodies against the N-methyl-d-aspartate receptor: A gate to the involvement of autoimmunity in the pathophysiology of bipolar illness.
title_fullStr Bipolar disorder and antibodies against the N-methyl-d-aspartate receptor: A gate to the involvement of autoimmunity in the pathophysiology of bipolar illness.
title_full_unstemmed Bipolar disorder and antibodies against the N-methyl-d-aspartate receptor: A gate to the involvement of autoimmunity in the pathophysiology of bipolar illness.
title_sort Bipolar disorder and antibodies against the N-methyl-d-aspartate receptor: A gate to the involvement of autoimmunity in the pathophysiology of bipolar illness.
dc.creator.none.fl_str_mv León Caballero, Jordi
Pacchiarotti, Isabella
Murru, Andrea
Valentí, M.
Colom, Francesc
Benach, B.
Pérez Solà, Víctor
Dalmau, Josep
Vieta, Eduard
author León Caballero, Jordi
author_facet León Caballero, Jordi
Pacchiarotti, Isabella
Murru, Andrea
Valentí, M.
Colom, Francesc
Benach, B.
Pérez Solà, Víctor
Dalmau, Josep
Vieta, Eduard
author_role author
author2 Pacchiarotti, Isabella
Murru, Andrea
Valentí, M.
Colom, Francesc
Benach, B.
Pérez Solà, Víctor
Dalmau, Josep
Vieta, Eduard
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Psicosi maniacodepressiva
Autoimmunitat
Depressió psíquica
topic Psicosi maniacodepressiva
Autoimmunitat
Depressió psíquica
description The high prevalence of comorbidity between bipolar disorder (BD) and other medical conditions, including autoimmune diseases, supports the hypothesis of the nature of BD as a biological illness category. Hence, an immune dysregulation process may play an important role in the development of at least certain subtypes of BD. Increasing evidence also suggests that the N-methyl-d-aspartate receptor (NMDAR) may be relevant in the pathophysiology of BD. A possible key mechanism underlying the physiopathology of certain autoimmune diseases that may present with affective symptoms might be the production of anti-NMDAR auto-antibodies (auto-Abs). The best characterized autoimmune anti-NMDAR disease is the anti-NMDAR encephalitis. It has been found that 4% of these patients present isolated, mostly affective, psychiatric manifestations during their illness. An interesting suggestion emerged from this overview is that the same mechanisms that trigger affective symptoms in patients with increased anti-NMDAR auto-Abs levels could be involved in the physiopathology of at least a subgroup of BD. Future studies are needed to characterize the relationship between anti-NMDAR auto-Abs and BD.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/25110
http://dx.doi.org/10.1016/j.neubiorev.2015.05.012
url http://hdl.handle.net/10230/25110
http://dx.doi.org/10.1016/j.neubiorev.2015.05.012
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Neuroscience & Biobehavioral Reviews. 2015 Aug;55:403-12
dc.rights.none.fl_str_mv Copyright © 2015 Elsevier Ltd. All rights reserved.
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright © 2015 Elsevier Ltd. All rights reserved.
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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