Cannabis use and cognitive biases in people with first-episode psychosis and their siblings

Background. Cannabis use and familial vulnerability to psychosis have been associated with social cognition deficits. This study examined the potential relationship between cannabis use and cognitive biases underlying social cognition and functioning in patients with first episode psychosis (FEP), t...

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Autores: Roldan, L, Sánchez-Gutiérrez, T, Fernández-Arias, I, Rodríguez-Toscano, E, López, G, Merchán-Naranjo, J, Calvo, A, Rapado-Castro, M, Parellada, M, Moreno, C, Ferraro, L, La Barbera, D, La Cascia, C, Tripoli, G, Di Forti, M, Murray, RM, Quattrone, D, Morgan, C, Gayer-Anderson, C, Jones, PB, Jongsma, HE, Kirkbride, JB, van Os, J, Garcia-Portilla, P, Al-Halabi, S, Bobes, J, de Haan, L, Bernardo, M, Santos, JL, Sanjuan, J, Arrojo, M, Szoke, A, Rutten, BP, Stilo, SA, Tarricone, I, Lasalvia, A, Tosato, S, Llorca, PM, Menezes, PR, Selten, JP, Tortelli, A, Velthorst, E, Del-Ben, CM, Arango, C, Díaz-Caneja, CM
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:INCLIVA
Repositorio:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
OAI Identifier:oai:incliva.fundanetsuite.com:p20012
Acceso en línea:https://incliva.portalinvestigacion.com/publicaciones/20012
Access Level:acceso abierto
Palabra clave:aberrance salience
cannabis
cognition
facial recognition
jumping to conclusions
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repository_id_str
spelling Cannabis use and cognitive biases in people with first-episode psychosis and their siblingsRoldan, LSánchez-Gutiérrez, TFernández-Arias, IRodríguez-Toscano, ELópez, GMerchán-Naranjo, JCalvo, ARapado-Castro, MParellada, MMoreno, CFerraro, LLa Barbera, DLa Cascia, CTripoli, GDi Forti, MMurray, RMQuattrone, DMorgan, CGayer-Anderson, CJones, PBJongsma, HEKirkbride, JBvan Os, JGarcia-Portilla, PAl-Halabi, SBobes, Jde Haan, LBernardo, MSantos, JLSanjuan, JArrojo, MSzoke, ARutten, BPStilo, SATarricone, ILasalvia, ATosato, SLlorca, PMMenezes, PRSelten, JPTortelli, AVelthorst, EDel-Ben, CMArango, CDíaz-Caneja, CMaberrance saliencecannabiscognitionfacial recognitionjumping to conclusionsBackground. Cannabis use and familial vulnerability to psychosis have been associated with social cognition deficits. This study examined the potential relationship between cannabis use and cognitive biases underlying social cognition and functioning in patients with first episode psychosis (FEP), their siblings, and controls.<br /> Methods. We analyzed a sample of 543 participants with FEP, 203 siblings, and 1168 controls from the EU-GEI study using a correlational design. We used logistic regression analyses to examine the influence of clinical group, lifetime cannabis use frequency, and potency of cannabis use on cognitive biases, accounting for demographic and cognitive variables.<br /> Results. FEP patients showed increased odds of facial recognition processing (FRP) deficits (OR = 1.642, CI 1.123-2.402) relative to controls but not of speech illusions (SI) or jumping to conclusions (JTC) bias, with no statistically significant differences relative to siblings. Daily and occasional lifetime cannabis use were associated with decreased odds of SI (OR = 0.605, CI 0.368-0.997 and OR = 0.646, CI 0.457-0.913 respectively) and JTC bias (OR = 0.625, CI 0.422-0.925 and OR = 0.602, CI 0.460-0.787 respectively) compared with lifetime abstinence, but not with FRP deficits, in the whole sample. Within the cannabis user group, low-potency cannabis use was associated with increased odds of SI (OR = 1.829, CI 1.297-2.578, FRP deficits (OR = 1.393, CI 1.031-1.882, and JTC (OR = 1.661, CI 1.271-2.171) relative to high-potency cannabis use, with comparable effects in the three clinical groups.<br /> Conclusions. Our findings suggest increased odds of cognitive biases in FEP patients who have never used cannabis and in low-potency users. Future studies should elucidate this association and its potential implications.CAMBRIDGE UNIV PRESS2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://incliva.portalinvestigacion.com/publicaciones/20012PSYCHOLOGICAL MEDICINEISSN: 00332917ISSNe: 14698978reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVAinstname:INCLIVAInglésinfo:eu-repo/semantics/openAccessoai:incliva.fundanetsuite.com:p200122026-06-07T16:35:31Z
dc.title.none.fl_str_mv Cannabis use and cognitive biases in people with first-episode psychosis and their siblings
title Cannabis use and cognitive biases in people with first-episode psychosis and their siblings
spellingShingle Cannabis use and cognitive biases in people with first-episode psychosis and their siblings
Roldan, L
aberrance salience
cannabis
cognition
facial recognition
jumping to conclusions
title_short Cannabis use and cognitive biases in people with first-episode psychosis and their siblings
title_full Cannabis use and cognitive biases in people with first-episode psychosis and their siblings
title_fullStr Cannabis use and cognitive biases in people with first-episode psychosis and their siblings
title_full_unstemmed Cannabis use and cognitive biases in people with first-episode psychosis and their siblings
title_sort Cannabis use and cognitive biases in people with first-episode psychosis and their siblings
dc.creator.none.fl_str_mv Roldan, L
Sánchez-Gutiérrez, T
Fernández-Arias, I
Rodríguez-Toscano, E
López, G
Merchán-Naranjo, J
Calvo, A
Rapado-Castro, M
Parellada, M
Moreno, C
Ferraro, L
La Barbera, D
La Cascia, C
Tripoli, G
Di Forti, M
Murray, RM
Quattrone, D
Morgan, C
Gayer-Anderson, C
Jones, PB
Jongsma, HE
Kirkbride, JB
van Os, J
Garcia-Portilla, P
Al-Halabi, S
Bobes, J
de Haan, L
Bernardo, M
Santos, JL
Sanjuan, J
Arrojo, M
Szoke, A
Rutten, BP
Stilo, SA
Tarricone, I
Lasalvia, A
Tosato, S
Llorca, PM
Menezes, PR
Selten, JP
Tortelli, A
Velthorst, E
Del-Ben, CM
Arango, C
Díaz-Caneja, CM
author Roldan, L
author_facet Roldan, L
Sánchez-Gutiérrez, T
Fernández-Arias, I
Rodríguez-Toscano, E
López, G
Merchán-Naranjo, J
Calvo, A
Rapado-Castro, M
Parellada, M
Moreno, C
Ferraro, L
La Barbera, D
La Cascia, C
Tripoli, G
Di Forti, M
Murray, RM
Quattrone, D
Morgan, C
Gayer-Anderson, C
Jones, PB
Jongsma, HE
Kirkbride, JB
van Os, J
Garcia-Portilla, P
Al-Halabi, S
Bobes, J
de Haan, L
Bernardo, M
Santos, JL
Sanjuan, J
Arrojo, M
Szoke, A
Rutten, BP
Stilo, SA
Tarricone, I
Lasalvia, A
Tosato, S
Llorca, PM
Menezes, PR
Selten, JP
Tortelli, A
Velthorst, E
Del-Ben, CM
Arango, C
Díaz-Caneja, CM
author_role author
author2 Sánchez-Gutiérrez, T
Fernández-Arias, I
Rodríguez-Toscano, E
López, G
Merchán-Naranjo, J
Calvo, A
Rapado-Castro, M
Parellada, M
Moreno, C
Ferraro, L
La Barbera, D
La Cascia, C
Tripoli, G
Di Forti, M
Murray, RM
Quattrone, D
Morgan, C
Gayer-Anderson, C
Jones, PB
Jongsma, HE
Kirkbride, JB
van Os, J
Garcia-Portilla, P
Al-Halabi, S
Bobes, J
de Haan, L
Bernardo, M
Santos, JL
Sanjuan, J
Arrojo, M
Szoke, A
Rutten, BP
Stilo, SA
Tarricone, I
Lasalvia, A
Tosato, S
Llorca, PM
Menezes, PR
Selten, JP
Tortelli, A
Velthorst, E
Del-Ben, CM
Arango, C
Díaz-Caneja, CM
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv aberrance salience
cannabis
cognition
facial recognition
jumping to conclusions
topic aberrance salience
cannabis
cognition
facial recognition
jumping to conclusions
description Background. Cannabis use and familial vulnerability to psychosis have been associated with social cognition deficits. This study examined the potential relationship between cannabis use and cognitive biases underlying social cognition and functioning in patients with first episode psychosis (FEP), their siblings, and controls.<br /> Methods. We analyzed a sample of 543 participants with FEP, 203 siblings, and 1168 controls from the EU-GEI study using a correlational design. We used logistic regression analyses to examine the influence of clinical group, lifetime cannabis use frequency, and potency of cannabis use on cognitive biases, accounting for demographic and cognitive variables.<br /> Results. FEP patients showed increased odds of facial recognition processing (FRP) deficits (OR = 1.642, CI 1.123-2.402) relative to controls but not of speech illusions (SI) or jumping to conclusions (JTC) bias, with no statistically significant differences relative to siblings. Daily and occasional lifetime cannabis use were associated with decreased odds of SI (OR = 0.605, CI 0.368-0.997 and OR = 0.646, CI 0.457-0.913 respectively) and JTC bias (OR = 0.625, CI 0.422-0.925 and OR = 0.602, CI 0.460-0.787 respectively) compared with lifetime abstinence, but not with FRP deficits, in the whole sample. Within the cannabis user group, low-potency cannabis use was associated with increased odds of SI (OR = 1.829, CI 1.297-2.578, FRP deficits (OR = 1.393, CI 1.031-1.882, and JTC (OR = 1.661, CI 1.271-2.171) relative to high-potency cannabis use, with comparable effects in the three clinical groups.<br /> Conclusions. Our findings suggest increased odds of cognitive biases in FEP patients who have never used cannabis and in low-potency users. Future studies should elucidate this association and its potential implications.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://incliva.portalinvestigacion.com/publicaciones/20012
url https://incliva.portalinvestigacion.com/publicaciones/20012
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv CAMBRIDGE UNIV PRESS
publisher.none.fl_str_mv CAMBRIDGE UNIV PRESS
dc.source.none.fl_str_mv PSYCHOLOGICAL MEDICINE
ISSN: 00332917
ISSNe: 14698978
reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname:INCLIVA
instname_str INCLIVA
reponame_str r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
collection r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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