Chronic treatment with somatostatin analogues in recurrent type 1 gastric neuroendocrine tumors

Type 1 gastric neuroendocrine tumors (GC-1) represent an uncommon subtype of neoplasms. Endoscopic resection has been proposed as the treatment of choice; active surveillance may be performed in those smaller than 1 cm, while gastric surgery may be performed for those with frequent recurrences. The...

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Autores: Sebastián Valles, Fernando, Bernaldo Madrid, Blanca, Sager La Ganga, Carolina, Carrillo López, Elena, Mera Carreiro, Sara, Ávila Antón, Laura, Sánchez-Maroto García, Noelia, Sampedro Núñez, Miguel Antonio, Díaz Pérez, Jose Ángel, Marazuela Azpiroz, Mónica
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/708684
Acceso en línea:http://hdl.handle.net/10486/708684
https://dx.doi.org/10.3390/biomedicines11030872
Access Level:acceso abierto
Palabra clave:gastric neuroendocrine tumors
gastric carcinoids
somatostatin analogs
lanreotide
octreotide
Medicina
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spelling Chronic treatment with somatostatin analogues in recurrent type 1 gastric neuroendocrine tumorsSebastián Valles, FernandoBernaldo Madrid, BlancaSager La Ganga, CarolinaCarrillo López, ElenaMera Carreiro, SaraÁvila Antón, LauraSánchez-Maroto García, NoeliaSampedro Núñez, Miguel AntonioDíaz Pérez, Jose ÁngelMarazuela Azpiroz, Mónicagastric neuroendocrine tumorsgastric carcinoidssomatostatin analogslanreotideoctreotideMedicinaType 1 gastric neuroendocrine tumors (GC-1) represent an uncommon subtype of neoplasms. Endoscopic resection has been proposed as the treatment of choice; active surveillance may be performed in those smaller than 1 cm, while gastric surgery may be performed for those with frequent recurrences. The antiproliferative effect of somatostatin analogues (SSA) is well known, and their action on GC-1s has been postulated as a chronic treatment to reduce recurrence. Methods: A two-centered, retrospective, observational study that included nine patients (55.6% women) diagnosed with GC-1, receiving long-term treatment with SSA, with a median follow-up from baseline of 22 months, was undertaken. Endoscopic follow-up, extension study, and analytical values of chromogranin A (Cg A) and gastrin were collected. Results: In total, 88.9% of patients presented partial or complete response. Treatment with SSA was the only independent factor with a trend to prevent tumor recurrence (Odds Ratio 0.054; p = 0.005). A nonsignificant tendency toward a decrease in CgA and gastrin was observed; lack of significance was probably related to concomitant treatment with proton pump inhibitors in some patients. Conclusions: Chronic treatment with SSA is a feasible option for recurrent GC-1s that are difficult to manage using endoscopy or gastrectomy. Randomized clinical trials to provide more scientific evidence are still neededMDPIDepartamento de MedicinaFacultad de Medicina20232023-03-13research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/708684https://dx.doi.org/10.3390/biomedicines11030872reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/7086842026-06-23T12:46:27Z
dc.title.none.fl_str_mv Chronic treatment with somatostatin analogues in recurrent type 1 gastric neuroendocrine tumors
title Chronic treatment with somatostatin analogues in recurrent type 1 gastric neuroendocrine tumors
spellingShingle Chronic treatment with somatostatin analogues in recurrent type 1 gastric neuroendocrine tumors
Sebastián Valles, Fernando
gastric neuroendocrine tumors
gastric carcinoids
somatostatin analogs
lanreotide
octreotide
Medicina
title_short Chronic treatment with somatostatin analogues in recurrent type 1 gastric neuroendocrine tumors
title_full Chronic treatment with somatostatin analogues in recurrent type 1 gastric neuroendocrine tumors
title_fullStr Chronic treatment with somatostatin analogues in recurrent type 1 gastric neuroendocrine tumors
title_full_unstemmed Chronic treatment with somatostatin analogues in recurrent type 1 gastric neuroendocrine tumors
title_sort Chronic treatment with somatostatin analogues in recurrent type 1 gastric neuroendocrine tumors
dc.creator.none.fl_str_mv Sebastián Valles, Fernando
Bernaldo Madrid, Blanca
Sager La Ganga, Carolina
Carrillo López, Elena
Mera Carreiro, Sara
Ávila Antón, Laura
Sánchez-Maroto García, Noelia
Sampedro Núñez, Miguel Antonio
Díaz Pérez, Jose Ángel
Marazuela Azpiroz, Mónica
author Sebastián Valles, Fernando
author_facet Sebastián Valles, Fernando
Bernaldo Madrid, Blanca
Sager La Ganga, Carolina
Carrillo López, Elena
Mera Carreiro, Sara
Ávila Antón, Laura
Sánchez-Maroto García, Noelia
Sampedro Núñez, Miguel Antonio
Díaz Pérez, Jose Ángel
Marazuela Azpiroz, Mónica
author_role author
author2 Bernaldo Madrid, Blanca
Sager La Ganga, Carolina
Carrillo López, Elena
Mera Carreiro, Sara
Ávila Antón, Laura
Sánchez-Maroto García, Noelia
Sampedro Núñez, Miguel Antonio
Díaz Pérez, Jose Ángel
Marazuela Azpiroz, Mónica
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Medicina
Facultad de Medicina
dc.subject.none.fl_str_mv gastric neuroendocrine tumors
gastric carcinoids
somatostatin analogs
lanreotide
octreotide
Medicina
topic gastric neuroendocrine tumors
gastric carcinoids
somatostatin analogs
lanreotide
octreotide
Medicina
description Type 1 gastric neuroendocrine tumors (GC-1) represent an uncommon subtype of neoplasms. Endoscopic resection has been proposed as the treatment of choice; active surveillance may be performed in those smaller than 1 cm, while gastric surgery may be performed for those with frequent recurrences. The antiproliferative effect of somatostatin analogues (SSA) is well known, and their action on GC-1s has been postulated as a chronic treatment to reduce recurrence. Methods: A two-centered, retrospective, observational study that included nine patients (55.6% women) diagnosed with GC-1, receiving long-term treatment with SSA, with a median follow-up from baseline of 22 months, was undertaken. Endoscopic follow-up, extension study, and analytical values of chromogranin A (Cg A) and gastrin were collected. Results: In total, 88.9% of patients presented partial or complete response. Treatment with SSA was the only independent factor with a trend to prevent tumor recurrence (Odds Ratio 0.054; p = 0.005). A nonsignificant tendency toward a decrease in CgA and gastrin was observed; lack of significance was probably related to concomitant treatment with proton pump inhibitors in some patients. Conclusions: Chronic treatment with SSA is a feasible option for recurrent GC-1s that are difficult to manage using endoscopy or gastrectomy. Randomized clinical trials to provide more scientific evidence are still needed
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-03-13
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/708684
https://dx.doi.org/10.3390/biomedicines11030872
url http://hdl.handle.net/10486/708684
https://dx.doi.org/10.3390/biomedicines11030872
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301603

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