MRI brain tumor segmentation and uncertainty estimation using 3D-UNet architectures

Automation of brain tumor segmentation in 3D magnetic resonance images (MRIs) is key to assess the diagnostic and treatment of the disease. In recent years, convolutional neural networks (CNNs) have shown improved results in the task. However, high memory consumption is still a problem in 3D-CNNs. M...

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Detalles Bibliográficos
Autores: Mora Ballestar, Laura, Vilaplana Besler, Verónica|||0000-0001-6924-9961
Tipo de recurso: capítulo de libro
Fecha de publicación:2021
País:España
Institución:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:upcommons.upc.edu:2117/360072
Acceso en línea:https://hdl.handle.net/2117/360072
https://dx.doi.org/10.1007/978-3-030-72084-1_34
Access Level:acceso abierto
Palabra clave:Brain -- Magnetic resonance imaging
Brain -- Tumors -- Diagnosis
Brain tumor segmentation
Deep learning
Uncertainty
3d convolutional neural networks
Cervell -- Imatgeria per ressonància magnètica
Cervell -- Tumors -- Diagnòstic
Àrees temàtiques de la UPC::Enginyeria de la telecomunicació::Processament del senyal::Processament de la imatge i del senyal vídeo
Descripción
Sumario:Automation of brain tumor segmentation in 3D magnetic resonance images (MRIs) is key to assess the diagnostic and treatment of the disease. In recent years, convolutional neural networks (CNNs) have shown improved results in the task. However, high memory consumption is still a problem in 3D-CNNs. Moreover, most methods do not include uncertainty information, which is especially critical in medical diagnosis. This work studies 3D encoder-decoder architectures trained with patch-based techniques to reduce memory consumption and decrease the effect of unbalanced data. The different trained models are then used to create an ensemble that leverages the properties of each model, thus increasing the performance. We also introduce voxel-wise uncertainty information, both epistemic and aleatoric using test-time dropout (TTD) and data-augmentation (TTA) respectively. In addition, a hybrid approach is proposed that helps increase the accuracy of the segmentation. The model and uncertainty estimation measurements proposed in this work have been used in the BraTS’20 Challenge for task 1 and 3 regarding tumor segmentation and uncertainty estimation.