Establishing and dissolving cohesion during the vertebrate cell cycle.

Replicated chromatids are held together from the time they emerge from the replication fork until their separation in anaphase. This process, known as cohesion, promotes faithful DNA repair by homologous recombination in interphase and ensures accurate chromosome segregation in mitosis. Identificati...

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Detalles Bibliográficos
Autores: Morales, Carmen, Losada, Ana
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/26236
Acceso en línea:https://hdl.handle.net/20.500.12105/26236
Access Level:acceso abierto
Palabra clave:SISTER-CHROMATID COHESION
CHROMOSOME BI-ORIENTATION
DNA-REPLICATION
AURORA B
CENTROMERIC COHESION
STRUCTURAL BASIS
LOADER SCC2
ACETYLATION
WAPL
MITOSIS
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spelling Establishing and dissolving cohesion during the vertebrate cell cycle.Morales, CarmenLosada, AnaSISTER-CHROMATID COHESIONCHROMOSOME BI-ORIENTATIONDNA-REPLICATIONAURORA BCENTROMERIC COHESIONSTRUCTURAL BASISLOADER SCC2ACETYLATIONWAPLMITOSISReplicated chromatids are held together from the time they emerge from the replication fork until their separation in anaphase. This process, known as cohesion, promotes faithful DNA repair by homologous recombination in interphase and ensures accurate chromosome segregation in mitosis. Identification of cohesin thirty years ago solved a long-standing question about the nature of the linkage keeping together the sister chromatids. Cohesin is an evolutionarily conserved complex composed of a heterodimer of the Structural Maintenance of Chromosomes (SMC) family of ATPases, Smc1 and Smc3, the kleisin subunit Rad21 and a Huntingtin/EF3/PP2A/Tor1 (HEAT) repeat domain-containing subunit named SA/STAG. In addition to mediating cohesion, cohesin plays a major role in genome organization. Cohesin functions rely on the ability of the complex to entrap DNA topologically and in a dynamic manner. Establishment of cohesion during S phase requires coordination with the DNA replication machinery and restricts the dynamic behaviour of at least a fraction of cohesin. Dissolution of cohesion in subsequent mitosis is regulated by multiple mechanisms that ensure that daughter cells receive the correct number of intact chromosomes. We here review recent progress on our understanding of how these processes are regulated in somatic vertebrate cells.ElsevierEuropean Union (EU)Ministerio de Econonmía y Comptetividad (España)FEDER funds20252025-02-0320182018-06-0120182018-06-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/vnd.openxmlformats-officedocument.wordprocessingml.documentapplication/pdfhttps://hdl.handle.net/20.500.12105/26236reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/262362026-06-12T12:43:37Z
dc.title.none.fl_str_mv Establishing and dissolving cohesion during the vertebrate cell cycle.
title Establishing and dissolving cohesion during the vertebrate cell cycle.
spellingShingle Establishing and dissolving cohesion during the vertebrate cell cycle.
Morales, Carmen
SISTER-CHROMATID COHESION
CHROMOSOME BI-ORIENTATION
DNA-REPLICATION
AURORA B
CENTROMERIC COHESION
STRUCTURAL BASIS
LOADER SCC2
ACETYLATION
WAPL
MITOSIS
title_short Establishing and dissolving cohesion during the vertebrate cell cycle.
title_full Establishing and dissolving cohesion during the vertebrate cell cycle.
title_fullStr Establishing and dissolving cohesion during the vertebrate cell cycle.
title_full_unstemmed Establishing and dissolving cohesion during the vertebrate cell cycle.
title_sort Establishing and dissolving cohesion during the vertebrate cell cycle.
dc.creator.none.fl_str_mv Morales, Carmen
Losada, Ana
author Morales, Carmen
author_facet Morales, Carmen
Losada, Ana
author_role author
author2 Losada, Ana
author2_role author
dc.contributor.none.fl_str_mv European Union (EU)
Ministerio de Econonmía y Comptetividad (España)
FEDER funds
dc.subject.none.fl_str_mv SISTER-CHROMATID COHESION
CHROMOSOME BI-ORIENTATION
DNA-REPLICATION
AURORA B
CENTROMERIC COHESION
STRUCTURAL BASIS
LOADER SCC2
ACETYLATION
WAPL
MITOSIS
topic SISTER-CHROMATID COHESION
CHROMOSOME BI-ORIENTATION
DNA-REPLICATION
AURORA B
CENTROMERIC COHESION
STRUCTURAL BASIS
LOADER SCC2
ACETYLATION
WAPL
MITOSIS
description Replicated chromatids are held together from the time they emerge from the replication fork until their separation in anaphase. This process, known as cohesion, promotes faithful DNA repair by homologous recombination in interphase and ensures accurate chromosome segregation in mitosis. Identification of cohesin thirty years ago solved a long-standing question about the nature of the linkage keeping together the sister chromatids. Cohesin is an evolutionarily conserved complex composed of a heterodimer of the Structural Maintenance of Chromosomes (SMC) family of ATPases, Smc1 and Smc3, the kleisin subunit Rad21 and a Huntingtin/EF3/PP2A/Tor1 (HEAT) repeat domain-containing subunit named SA/STAG. In addition to mediating cohesion, cohesin plays a major role in genome organization. Cohesin functions rely on the ability of the complex to entrap DNA topologically and in a dynamic manner. Establishment of cohesion during S phase requires coordination with the DNA replication machinery and restricts the dynamic behaviour of at least a fraction of cohesin. Dissolution of cohesion in subsequent mitosis is regulated by multiple mechanisms that ensure that daughter cells receive the correct number of intact chromosomes. We here review recent progress on our understanding of how these processes are regulated in somatic vertebrate cells.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-06-01
2018
2018-06-01
2025
2025-02-03
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.12105/26236
url https://hdl.handle.net/20.500.12105/26236
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/vnd.openxmlformats-officedocument.wordprocessingml.document
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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