Heterogeneity of reduced FEV1 in early adulthood: A looking forward, looking backwards analysis

Background Some individuals never achieve normal peak FEV1 in early adulthood. It is unknown if this is due to airflow limitation and/or lung restriction. Methods To investigate this, we: (1) looked forward in 19,791 participants in the Dutch Lifelines general population cohort aged 25–35 years with...

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Autores: Olvera Ocaña, Núria, Agustí García-Navarro, Àlvar, Vonk, Judith M., Wang, Guangchuan, Hallberg, J., Boezen, H.M., Berge, Maarten van den, Melén, Erik, Faner, Rosa
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Universidad de Oviedo (UNIOVI)
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:dnet:ubarcelona__::8016a522a37e7c1a92ba3ff000d4f3fe
Acceso en línea:https://hdl.handle.net/2445/229706
Access Level:acceso abierto
Palabra clave:Bronquitis
Factors d&apos
edat en les malalties
Emfisema pulmonar
Bronchitis
Age factors in disease
Pulmonary emphysema
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spelling Heterogeneity of reduced FEV1 in early adulthood: A looking forward, looking backwards analysisHeterogeneity of reduced <scp>FEV<sub>1</sub></scp> in early adulthood: A looking forward, looking backwards analysisOlvera Ocaña, NúriaAgustí García-Navarro, ÀlvarVonk, Judith M.Wang, GuangchuanHallberg, J.Boezen, H.M.Berge, Maarten van denMelén, ErikFaner, RosaBronquitisFactors d&aposedat en les malaltiesEmfisema pulmonarBronchitisAge factors in diseasePulmonary emphysemaBackground Some individuals never achieve normal peak FEV1 in early adulthood. It is unknown if this is due to airflow limitation and/or lung restriction. Methods To investigate this, we: (1) looked forward in 19,791 participants in the Dutch Lifelines general population cohort aged 25–35 years with 5-year follow-up; and (2) looked backwards in 2032 participants in the Swedish BAMSE birth cohort with spirometry at 24 years of age but also at 16 and/or 8 years. Results (1) In Lifelines 8.5% of participants had reduced FEV1 at 25–35 years, 68% due to Preserved Ratio Impaired Spirometry (‘PRISm’) and 32% to airflow limitation (‘low-limited’); besides, 3.8% participants with normal FEV1 showed airflow-limitation (‘normal-limited’). Low-limited and normal-limited, but not PRISm, reported higher smoking exposures and asthma diagnosis than normal (p < 0.05). At 5-year follow-up, 91.2% of participants remained in the same group, and FEV1 decline was similar in normal and normal-limited participants, but statistically smaller (p < 0.05) in PRISm and low-limited; (2) these observations were largely reproduced in BAMSE at 24 years of age; and, (3) in BAMSE, low-limited or PRISm individuals were already identifiable at 8–16 years of age. Conclusion Low peak FEV1 in early adulthood is most often due to PRISm and results in a significant burden of respiratory symptoms. Only low-limited and normal-limited, but not PRISm, associate with a doctor diagnosis of asthma, and FEV1 decline was statistically different in PRISm indicating a need for differentiated clinical approaches. These spirometric abnormalities can be already identified in childhood and adolescence.Blackwell2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/229706reponame:Dipòsit Digital de la UBinstname:Universidad de Oviedo (UNIOVI)InglésReproducció del document publicat a: https://doi.org/10.1111/resp.14876Respirology, 2025, vol. 30, num.4, p. 326-334https://doi.org/10.1111/resp.14876cc-by-nc-nd (c) Olvera Ocaña, Núria et al., 2025https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:dnet:ubarcelona__::8016a522a37e7c1a92ba3ff000d4f3fe2026-05-27T06:46:51Z
dc.title.none.fl_str_mv Heterogeneity of reduced FEV1 in early adulthood: A looking forward, looking backwards analysis
Heterogeneity of reduced <scp>FEV<sub>1</sub></scp> in early adulthood: A looking forward, looking backwards analysis
title Heterogeneity of reduced FEV1 in early adulthood: A looking forward, looking backwards analysis
spellingShingle Heterogeneity of reduced FEV1 in early adulthood: A looking forward, looking backwards analysis
Olvera Ocaña, Núria
Bronquitis
Factors d&apos
edat en les malalties
Emfisema pulmonar
Bronchitis
Age factors in disease
Pulmonary emphysema
title_short Heterogeneity of reduced FEV1 in early adulthood: A looking forward, looking backwards analysis
title_full Heterogeneity of reduced FEV1 in early adulthood: A looking forward, looking backwards analysis
title_fullStr Heterogeneity of reduced FEV1 in early adulthood: A looking forward, looking backwards analysis
title_full_unstemmed Heterogeneity of reduced FEV1 in early adulthood: A looking forward, looking backwards analysis
title_sort Heterogeneity of reduced FEV1 in early adulthood: A looking forward, looking backwards analysis
dc.creator.none.fl_str_mv Olvera Ocaña, Núria
Agustí García-Navarro, Àlvar
Vonk, Judith M.
Wang, Guangchuan
Hallberg, J.
Boezen, H.M.
Berge, Maarten van den
Melén, Erik
Faner, Rosa
author Olvera Ocaña, Núria
author_facet Olvera Ocaña, Núria
Agustí García-Navarro, Àlvar
Vonk, Judith M.
Wang, Guangchuan
Hallberg, J.
Boezen, H.M.
Berge, Maarten van den
Melén, Erik
Faner, Rosa
author_role author
author2 Agustí García-Navarro, Àlvar
Vonk, Judith M.
Wang, Guangchuan
Hallberg, J.
Boezen, H.M.
Berge, Maarten van den
Melén, Erik
Faner, Rosa
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Bronquitis
Factors d&apos
edat en les malalties
Emfisema pulmonar
Bronchitis
Age factors in disease
Pulmonary emphysema
topic Bronquitis
Factors d&apos
edat en les malalties
Emfisema pulmonar
Bronchitis
Age factors in disease
Pulmonary emphysema
description Background Some individuals never achieve normal peak FEV1 in early adulthood. It is unknown if this is due to airflow limitation and/or lung restriction. Methods To investigate this, we: (1) looked forward in 19,791 participants in the Dutch Lifelines general population cohort aged 25–35 years with 5-year follow-up; and (2) looked backwards in 2032 participants in the Swedish BAMSE birth cohort with spirometry at 24 years of age but also at 16 and/or 8 years. Results (1) In Lifelines 8.5% of participants had reduced FEV1 at 25–35 years, 68% due to Preserved Ratio Impaired Spirometry (‘PRISm’) and 32% to airflow limitation (‘low-limited’); besides, 3.8% participants with normal FEV1 showed airflow-limitation (‘normal-limited’). Low-limited and normal-limited, but not PRISm, reported higher smoking exposures and asthma diagnosis than normal (p < 0.05). At 5-year follow-up, 91.2% of participants remained in the same group, and FEV1 decline was similar in normal and normal-limited participants, but statistically smaller (p < 0.05) in PRISm and low-limited; (2) these observations were largely reproduced in BAMSE at 24 years of age; and, (3) in BAMSE, low-limited or PRISm individuals were already identifiable at 8–16 years of age. Conclusion Low peak FEV1 in early adulthood is most often due to PRISm and results in a significant burden of respiratory symptoms. Only low-limited and normal-limited, but not PRISm, associate with a doctor diagnosis of asthma, and FEV1 decline was statistically different in PRISm indicating a need for differentiated clinical approaches. These spirometric abnormalities can be already identified in childhood and adolescence.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/229706
url https://hdl.handle.net/2445/229706
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1111/resp.14876
Respirology, 2025, vol. 30, num.4, p. 326-334
https://doi.org/10.1111/resp.14876
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Olvera Ocaña, Núria et al., 2025
https://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Olvera Ocaña, Núria et al., 2025
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Blackwell
publisher.none.fl_str_mv Blackwell
dc.source.none.fl_str_mv reponame:Dipòsit Digital de la UB
instname:Universidad de Oviedo (UNIOVI)
instname_str Universidad de Oviedo (UNIOVI)
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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