Digital Monitoring of Patients with Generalized Myasthenia Gravis: A Prospective Pilot Study

Introduction: Monitoring patients with myasthenia gravis (MG) can be challenging due to the fluctuating nature of the disease. We aimed to test the reliability of using the MG Activities of Daily Living (MG-ADL) scale in the form of a smartphone application as a means for optimal patient monitoring...

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Autores: Vesperinas, A, Rocaspana-Codana, J, Reyes-Leiva, D, Caballero-Avila, M, Carbayo, A, Collet-Vidiella, R, Llansó, L, Gallardo, E, Turon-Sans, J, Rojas-García, R, Cortés-Vicente, E
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2026
País:España
Recursos:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:dnet:r-iibsantpa_::1909eccf7d60eaeb1e17c6585c9103bb
Acesso em linha:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=21880
Access Level:acceso abierto
Palavra-chave:Myasthenia gravis
Exacerbation
Smartphone application
Remote monitoring
Patient-reported outcomes
Myasthenia gravis activities of daily living scale
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spelling Digital Monitoring of Patients with Generalized Myasthenia Gravis: A Prospective Pilot StudyVesperinas, ARocaspana-Codana, JReyes-Leiva, DCaballero-Avila, MCarbayo, ACollet-Vidiella, RLlansó, LGallardo, ETuron-Sans, JRojas-García, RCortés-Vicente, EMyasthenia gravisExacerbationSmartphone applicationRemote monitoringPatient-reported outcomesMyasthenia gravis activities of daily living scaleIntroduction: Monitoring patients with myasthenia gravis (MG) can be challenging due to the fluctuating nature of the disease. We aimed to test the reliability of using the MG Activities of Daily Living (MG-ADL) scale in the form of a smartphone application as a means for optimal patient monitoring and early exacerbation detection. Methods: We conducted an observational, prospective, single-center study including patients with generalized MG at risk of clinical worsening. Follow-up was based on routine outpatient visits, remote monitoring via weekly self-completion of the MG-ADL scale, and home visits by specialist nurses. Results: Thirty-one patients were included [41.9% female; mean (SD) age 59 (15) years], 87.1% seropositive for anti-AChR antibodies. MG-ADL scores reported by the patient via the application showed excellent agreement with healthcare provider scores (ICC = 0.92, P < 0.01), moderate correlation with the MG Composite scale (rho = 0.595, P < 0.01), and weak correlation with the Quantitative MG scale (rho = 0.328, P < 0.01). Over the 15-month follow-up period, compared to 23 exacerbations detected during routine outpatient visits, the application detected 38 exacerbations in 14 patients, 20 of which led to therapeutic modifications. Conclusion: This study demonstrates the reliability of MG-ADL scale data obtained via a smartphone application in reflecting clinical status and in detecting deterioration episodes sometimes missed during routine outpatient visits.SPRINGER LONDON LTD2026info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=21880Neurology and TherapyISSN: 21938253ISSNe: 21936536reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:dnet:r-iibsantpa_::1909eccf7d60eaeb1e17c6585c9103bb2026-06-14T12:41:47Z
dc.title.none.fl_str_mv Digital Monitoring of Patients with Generalized Myasthenia Gravis: A Prospective Pilot Study
title Digital Monitoring of Patients with Generalized Myasthenia Gravis: A Prospective Pilot Study
spellingShingle Digital Monitoring of Patients with Generalized Myasthenia Gravis: A Prospective Pilot Study
Vesperinas, A
Myasthenia gravis
Exacerbation
Smartphone application
Remote monitoring
Patient-reported outcomes
Myasthenia gravis activities of daily living scale
title_short Digital Monitoring of Patients with Generalized Myasthenia Gravis: A Prospective Pilot Study
title_full Digital Monitoring of Patients with Generalized Myasthenia Gravis: A Prospective Pilot Study
title_fullStr Digital Monitoring of Patients with Generalized Myasthenia Gravis: A Prospective Pilot Study
title_full_unstemmed Digital Monitoring of Patients with Generalized Myasthenia Gravis: A Prospective Pilot Study
title_sort Digital Monitoring of Patients with Generalized Myasthenia Gravis: A Prospective Pilot Study
dc.creator.none.fl_str_mv Vesperinas, A
Rocaspana-Codana, J
Reyes-Leiva, D
Caballero-Avila, M
Carbayo, A
Collet-Vidiella, R
Llansó, L
Gallardo, E
Turon-Sans, J
Rojas-García, R
Cortés-Vicente, E
author Vesperinas, A
author_facet Vesperinas, A
Rocaspana-Codana, J
Reyes-Leiva, D
Caballero-Avila, M
Carbayo, A
Collet-Vidiella, R
Llansó, L
Gallardo, E
Turon-Sans, J
Rojas-García, R
Cortés-Vicente, E
author_role author
author2 Rocaspana-Codana, J
Reyes-Leiva, D
Caballero-Avila, M
Carbayo, A
Collet-Vidiella, R
Llansó, L
Gallardo, E
Turon-Sans, J
Rojas-García, R
Cortés-Vicente, E
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Myasthenia gravis
Exacerbation
Smartphone application
Remote monitoring
Patient-reported outcomes
Myasthenia gravis activities of daily living scale
topic Myasthenia gravis
Exacerbation
Smartphone application
Remote monitoring
Patient-reported outcomes
Myasthenia gravis activities of daily living scale
description Introduction: Monitoring patients with myasthenia gravis (MG) can be challenging due to the fluctuating nature of the disease. We aimed to test the reliability of using the MG Activities of Daily Living (MG-ADL) scale in the form of a smartphone application as a means for optimal patient monitoring and early exacerbation detection. Methods: We conducted an observational, prospective, single-center study including patients with generalized MG at risk of clinical worsening. Follow-up was based on routine outpatient visits, remote monitoring via weekly self-completion of the MG-ADL scale, and home visits by specialist nurses. Results: Thirty-one patients were included [41.9% female; mean (SD) age 59 (15) years], 87.1% seropositive for anti-AChR antibodies. MG-ADL scores reported by the patient via the application showed excellent agreement with healthcare provider scores (ICC = 0.92, P < 0.01), moderate correlation with the MG Composite scale (rho = 0.595, P < 0.01), and weak correlation with the Quantitative MG scale (rho = 0.328, P < 0.01). Over the 15-month follow-up period, compared to 23 exacerbations detected during routine outpatient visits, the application detected 38 exacerbations in 14 patients, 20 of which led to therapeutic modifications. Conclusion: This study demonstrates the reliability of MG-ADL scale data obtained via a smartphone application in reflecting clinical status and in detecting deterioration episodes sometimes missed during routine outpatient visits.
publishDate 2026
dc.date.none.fl_str_mv 2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=21880
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=21880
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv SPRINGER LONDON LTD
publisher.none.fl_str_mv SPRINGER LONDON LTD
dc.source.none.fl_str_mv Neurology and Therapy
ISSN: 21938253
ISSNe: 21936536
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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