Maternal Caloric Restriction Implemented during the Preconceptional and Pregnancy Period Alters Hypothalamic and Hippocampal Endocannabinoid Levels at Birth and Induces Overweight and Increased Adiposity at Adulthood in Male Rat Offspring

Exposure to inadequate nutritional conditions in critical windows of development has been associated to disturbances on metabolism and behavior in the offspring later in life. The role of the endocannabinoid system, a known regulator of energy expenditure and adaptive behaviors, in the modulation of...

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Autores: Ramírez López, María Teresa, Vázquez, Mariam, Bindila, Laura, Lomazzo, Ermelinda, Hofmann, Clementine, Blanco, Rosarío Noemí, Alén Fariñas, Francisco, Antón, María, Decara, Juan, Arco, Rocío, Ouro, Daniel, Orio Ortiz, Laura, Suárez, Juan, Lutz, Beat, Gómez De Heras, María Raquel, Rodríguez De Fonseca, Fernando Antonio
Tipo de recurso: artículo
Fecha de publicación:2016
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/121790
Acceso en línea:https://hdl.handle.net/20.500.14352/121790
Access Level:acceso abierto
Palabra clave:61
Maternal undernutrition
Endocannabinoids
Hypothalamus
Hippocampus
Rat
Development
Metabolism
Behavior
Ciencias Biomédicas
3299 Otras Especialidades Médicas
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spelling Maternal Caloric Restriction Implemented during the Preconceptional and Pregnancy Period Alters Hypothalamic and Hippocampal Endocannabinoid Levels at Birth and Induces Overweight and Increased Adiposity at Adulthood in Male Rat OffspringRamírez López, María TeresaVázquez, MariamBindila, LauraLomazzo, ErmelindaHofmann, ClementineBlanco, Rosarío NoemíAlén Fariñas, FranciscoAntón, MaríaDecara, JuanArco, RocíoOuro, DanielOrio Ortiz, LauraSuárez, JuanLutz, BeatGómez De Heras, María RaquelRodríguez De Fonseca, Fernando Antonio61Maternal undernutritionEndocannabinoidsHypothalamusHippocampusRatDevelopmentMetabolismBehaviorCiencias Biomédicas3299 Otras Especialidades MédicasExposure to inadequate nutritional conditions in critical windows of development has been associated to disturbances on metabolism and behavior in the offspring later in life. The role of the endocannabinoid system, a known regulator of energy expenditure and adaptive behaviors, in the modulation of these processes is unknown. In the present study, we investigated the impact of exposing rat dams to diet restriction (20% less calories than standard diet) during pre-gestational and gestational periods on: (a) neonatal outcomes; (b) endocannabinoid content in hypothalamus, hippocampus and olfactory bulb at birth; (c) metabolism-related parameters; and (d) behavior in adult male offspring. We found that calorie-restricted dams tended to have a reduced litter size, although the offspring showed normal weight at birth. Pups from calorie-restricted dams also exhibited a strong decrease in the levels of anandamide (AEA), 2-arachidonoylglycerol (2-AG), arachidonic acid (AA) and palmitoylethanolamide (PEA) in the hypothalamus at birth. Additionally, pups from diet-restricted dams displayed reduced levels of AEA in the hippocampus without significant differences in the olfactory bulb. Moreover, offspring exhibited increased weight gain, body weight and adiposity in adulthood as well as increased anxiety-related responses. We propose that endocannabinoid signaling is altered by a maternal caloric restriction implemented during the preconceptional and pregnancy periods, which might lead to modifications of the hypothalamic and hippocampal circuits, potentially contributing to the long-term effects found in the adult offspring.Frontiers Media SAUniversidad Complutense de Madrid20162016-11-0120162016-11-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/121790reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1217902026-06-02T12:44:21Z
dc.title.none.fl_str_mv Maternal Caloric Restriction Implemented during the Preconceptional and Pregnancy Period Alters Hypothalamic and Hippocampal Endocannabinoid Levels at Birth and Induces Overweight and Increased Adiposity at Adulthood in Male Rat Offspring
title Maternal Caloric Restriction Implemented during the Preconceptional and Pregnancy Period Alters Hypothalamic and Hippocampal Endocannabinoid Levels at Birth and Induces Overweight and Increased Adiposity at Adulthood in Male Rat Offspring
spellingShingle Maternal Caloric Restriction Implemented during the Preconceptional and Pregnancy Period Alters Hypothalamic and Hippocampal Endocannabinoid Levels at Birth and Induces Overweight and Increased Adiposity at Adulthood in Male Rat Offspring
Ramírez López, María Teresa
61
Maternal undernutrition
Endocannabinoids
Hypothalamus
Hippocampus
Rat
Development
Metabolism
Behavior
Ciencias Biomédicas
3299 Otras Especialidades Médicas
title_short Maternal Caloric Restriction Implemented during the Preconceptional and Pregnancy Period Alters Hypothalamic and Hippocampal Endocannabinoid Levels at Birth and Induces Overweight and Increased Adiposity at Adulthood in Male Rat Offspring
title_full Maternal Caloric Restriction Implemented during the Preconceptional and Pregnancy Period Alters Hypothalamic and Hippocampal Endocannabinoid Levels at Birth and Induces Overweight and Increased Adiposity at Adulthood in Male Rat Offspring
title_fullStr Maternal Caloric Restriction Implemented during the Preconceptional and Pregnancy Period Alters Hypothalamic and Hippocampal Endocannabinoid Levels at Birth and Induces Overweight and Increased Adiposity at Adulthood in Male Rat Offspring
title_full_unstemmed Maternal Caloric Restriction Implemented during the Preconceptional and Pregnancy Period Alters Hypothalamic and Hippocampal Endocannabinoid Levels at Birth and Induces Overweight and Increased Adiposity at Adulthood in Male Rat Offspring
title_sort Maternal Caloric Restriction Implemented during the Preconceptional and Pregnancy Period Alters Hypothalamic and Hippocampal Endocannabinoid Levels at Birth and Induces Overweight and Increased Adiposity at Adulthood in Male Rat Offspring
dc.creator.none.fl_str_mv Ramírez López, María Teresa
Vázquez, Mariam
Bindila, Laura
Lomazzo, Ermelinda
Hofmann, Clementine
Blanco, Rosarío Noemí
Alén Fariñas, Francisco
Antón, María
Decara, Juan
Arco, Rocío
Ouro, Daniel
Orio Ortiz, Laura
Suárez, Juan
Lutz, Beat
Gómez De Heras, María Raquel
Rodríguez De Fonseca, Fernando Antonio
author Ramírez López, María Teresa
author_facet Ramírez López, María Teresa
Vázquez, Mariam
Bindila, Laura
Lomazzo, Ermelinda
Hofmann, Clementine
Blanco, Rosarío Noemí
Alén Fariñas, Francisco
Antón, María
Decara, Juan
Arco, Rocío
Ouro, Daniel
Orio Ortiz, Laura
Suárez, Juan
Lutz, Beat
Gómez De Heras, María Raquel
Rodríguez De Fonseca, Fernando Antonio
author_role author
author2 Vázquez, Mariam
Bindila, Laura
Lomazzo, Ermelinda
Hofmann, Clementine
Blanco, Rosarío Noemí
Alén Fariñas, Francisco
Antón, María
Decara, Juan
Arco, Rocío
Ouro, Daniel
Orio Ortiz, Laura
Suárez, Juan
Lutz, Beat
Gómez De Heras, María Raquel
Rodríguez De Fonseca, Fernando Antonio
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 61
Maternal undernutrition
Endocannabinoids
Hypothalamus
Hippocampus
Rat
Development
Metabolism
Behavior
Ciencias Biomédicas
3299 Otras Especialidades Médicas
topic 61
Maternal undernutrition
Endocannabinoids
Hypothalamus
Hippocampus
Rat
Development
Metabolism
Behavior
Ciencias Biomédicas
3299 Otras Especialidades Médicas
description Exposure to inadequate nutritional conditions in critical windows of development has been associated to disturbances on metabolism and behavior in the offspring later in life. The role of the endocannabinoid system, a known regulator of energy expenditure and adaptive behaviors, in the modulation of these processes is unknown. In the present study, we investigated the impact of exposing rat dams to diet restriction (20% less calories than standard diet) during pre-gestational and gestational periods on: (a) neonatal outcomes; (b) endocannabinoid content in hypothalamus, hippocampus and olfactory bulb at birth; (c) metabolism-related parameters; and (d) behavior in adult male offspring. We found that calorie-restricted dams tended to have a reduced litter size, although the offspring showed normal weight at birth. Pups from calorie-restricted dams also exhibited a strong decrease in the levels of anandamide (AEA), 2-arachidonoylglycerol (2-AG), arachidonic acid (AA) and palmitoylethanolamide (PEA) in the hypothalamus at birth. Additionally, pups from diet-restricted dams displayed reduced levels of AEA in the hippocampus without significant differences in the olfactory bulb. Moreover, offspring exhibited increased weight gain, body weight and adiposity in adulthood as well as increased anxiety-related responses. We propose that endocannabinoid signaling is altered by a maternal caloric restriction implemented during the preconceptional and pregnancy periods, which might lead to modifications of the hypothalamic and hippocampal circuits, potentially contributing to the long-term effects found in the adult offspring.
publishDate 2016
dc.date.none.fl_str_mv 2016
2016-11-01
2016
2016-11-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/121790
url https://hdl.handle.net/20.500.14352/121790
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media SA
publisher.none.fl_str_mv Frontiers Media SA
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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