MFG-E8 (LACTADHERIN): a novel marker associated with cerebral amyloid angiopathy

Malaltia d'Alzheimer; Biomarcadors; Microdissecció de captura làser

Detalles Bibliográficos
Autores: Marazuela Fuentes, Paula, Solé Piñol, Montserrat, Bonaterra Pastra, Anna, Pizarro Gonzálvez, Jesús, Camacho Soriano, Jessica, Martinez Saez, Elena Antima, Castillo Ribelles, Laura, Pancorbo Rosal, Olalla, Rodriguez Luna, David, Pujadas Navinés, Francesc, Delgado Martínez, Maria Pilar, Hernandez Guillamon, Maria Mar
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:11351/7436
Acceso en línea:https://hdl.handle.net/11351/7436
http://hdl.handle.net/11351/7436
Access Level:acceso abierto
Palabra clave:Malalties cerebrovasculars - Patogènesi
Pèptids - Metabolisme
DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders::Intracranial Arterial Diseases::Cerebral Arterial Diseases::Cerebral Amyloid Angiopathy
Other subheadings::Other subheadings::Other subheadings::/pathology
CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Peptides::Amyloid beta-Peptides
Other subheadings::Other subheadings::Other subheadings::/metabolism
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares::enfermedades arteriales intracraneales::enfermedades arteriales cerebrales::angiopatía amiloide cerebral
Otros calificadores::Otros calificadores::Otros calificadores::/patología
COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::péptidos::péptidos beta amiloides
Otros calificadores::Otros calificadores::Otros calificadores::/metabolismo
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oai_identifier_str oai:recercat.cat:11351/7436
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv MFG-E8 (LACTADHERIN): a novel marker associated with cerebral amyloid angiopathy
title MFG-E8 (LACTADHERIN): a novel marker associated with cerebral amyloid angiopathy
spellingShingle MFG-E8 (LACTADHERIN): a novel marker associated with cerebral amyloid angiopathy
Marazuela Fuentes, Paula
Malalties cerebrovasculars - Patogènesi
Pèptids - Metabolisme
DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders::Intracranial Arterial Diseases::Cerebral Arterial Diseases::Cerebral Amyloid Angiopathy
Other subheadings::Other subheadings::Other subheadings::/pathology
CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Peptides::Amyloid beta-Peptides
Other subheadings::Other subheadings::Other subheadings::/metabolism
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares::enfermedades arteriales intracraneales::enfermedades arteriales cerebrales::angiopatía amiloide cerebral
Otros calificadores::Otros calificadores::Otros calificadores::/patología
COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::péptidos::péptidos beta amiloides
Otros calificadores::Otros calificadores::Otros calificadores::/metabolismo
title_short MFG-E8 (LACTADHERIN): a novel marker associated with cerebral amyloid angiopathy
title_full MFG-E8 (LACTADHERIN): a novel marker associated with cerebral amyloid angiopathy
title_fullStr MFG-E8 (LACTADHERIN): a novel marker associated with cerebral amyloid angiopathy
title_full_unstemmed MFG-E8 (LACTADHERIN): a novel marker associated with cerebral amyloid angiopathy
title_sort MFG-E8 (LACTADHERIN): a novel marker associated with cerebral amyloid angiopathy
dc.creator.none.fl_str_mv Marazuela Fuentes, Paula
Solé Piñol, Montserrat
Bonaterra Pastra, Anna
Pizarro Gonzálvez, Jesús
Camacho Soriano, Jessica
Martinez Saez, Elena Antima
Castillo Ribelles, Laura
Pancorbo Rosal, Olalla
Rodriguez Luna, David
Pujadas Navinés, Francesc
Delgado Martínez, Maria Pilar
Hernandez Guillamon, Maria Mar
author Marazuela Fuentes, Paula
author_facet Marazuela Fuentes, Paula
Solé Piñol, Montserrat
Bonaterra Pastra, Anna
Pizarro Gonzálvez, Jesús
Camacho Soriano, Jessica
Martinez Saez, Elena Antima
Castillo Ribelles, Laura
Pancorbo Rosal, Olalla
Rodriguez Luna, David
Pujadas Navinés, Francesc
Delgado Martínez, Maria Pilar
Hernandez Guillamon, Maria Mar
author_role author
author2 Solé Piñol, Montserrat
Bonaterra Pastra, Anna
Pizarro Gonzálvez, Jesús
Camacho Soriano, Jessica
Martinez Saez, Elena Antima
Castillo Ribelles, Laura
Pancorbo Rosal, Olalla
Rodriguez Luna, David
Pujadas Navinés, Francesc
Delgado Martínez, Maria Pilar
Hernandez Guillamon, Maria Mar
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Marazuela P, Solé M, Bonaterra-Pastra A, Pizarro J, Delgado P, Hernández-Guillamon M] Laboratori de Recerca Neurovascular, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Camacho J, Martínez-Sáez E] Servei de Patologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Castillo-Ribelles L] Servei de Bioquímica Clínica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Pancorbo O, Rodríguez-Luna D] Unitat d’Ictus, Servei de Neurologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Pujadas F] Servei de Neurologia, Unitat de Demència, Vall d’Hebron Hospital Universitari, Barcelona, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Malalties cerebrovasculars - Patogènesi
Pèptids - Metabolisme
DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders::Intracranial Arterial Diseases::Cerebral Arterial Diseases::Cerebral Amyloid Angiopathy
Other subheadings::Other subheadings::Other subheadings::/pathology
CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Peptides::Amyloid beta-Peptides
Other subheadings::Other subheadings::Other subheadings::/metabolism
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares::enfermedades arteriales intracraneales::enfermedades arteriales cerebrales::angiopatía amiloide cerebral
Otros calificadores::Otros calificadores::Otros calificadores::/patología
COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::péptidos::péptidos beta amiloides
Otros calificadores::Otros calificadores::Otros calificadores::/metabolismo
topic Malalties cerebrovasculars - Patogènesi
Pèptids - Metabolisme
DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders::Intracranial Arterial Diseases::Cerebral Arterial Diseases::Cerebral Amyloid Angiopathy
Other subheadings::Other subheadings::Other subheadings::/pathology
CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Peptides::Amyloid beta-Peptides
Other subheadings::Other subheadings::Other subheadings::/metabolism
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares::enfermedades arteriales intracraneales::enfermedades arteriales cerebrales::angiopatía amiloide cerebral
Otros calificadores::Otros calificadores::Otros calificadores::/patología
COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::péptidos::péptidos beta amiloides
Otros calificadores::Otros calificadores::Otros calificadores::/metabolismo
description Malaltia d'Alzheimer; Biomarcadors; Microdissecció de captura làser
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/7436
http://hdl.handle.net/11351/7436
url https://hdl.handle.net/11351/7436
http://hdl.handle.net/11351/7436
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Acta Neuropathologica Communications;9
https://doi.org/10.1186/s40478-021-01257-9
info:eu-repo/grantAgreement/ES/PE2017-2020/PI20%2F00465
info:eu-repo/grantAgreement/ES/PE2013-2016/RD16%2F0019%2F0021
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
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dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv Scientia
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling MFG-E8 (LACTADHERIN): a novel marker associated with cerebral amyloid angiopathyMarazuela Fuentes, PaulaSolé Piñol, MontserratBonaterra Pastra, AnnaPizarro Gonzálvez, JesúsCamacho Soriano, JessicaMartinez Saez, Elena AntimaCastillo Ribelles, LauraPancorbo Rosal, OlallaRodriguez Luna, DavidPujadas Navinés, FrancescDelgado Martínez, Maria PilarHernandez Guillamon, Maria MarMalalties cerebrovasculars - PatogènesiPèptids - MetabolismeDISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders::Intracranial Arterial Diseases::Cerebral Arterial Diseases::Cerebral Amyloid AngiopathyOther subheadings::Other subheadings::Other subheadings::/pathologyCHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Peptides::Amyloid beta-PeptidesOther subheadings::Other subheadings::Other subheadings::/metabolismENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares::enfermedades arteriales intracraneales::enfermedades arteriales cerebrales::angiopatía amiloide cerebralOtros calificadores::Otros calificadores::Otros calificadores::/patologíaCOMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::péptidos::péptidos beta amiloidesOtros calificadores::Otros calificadores::Otros calificadores::/metabolismoMalaltia d'Alzheimer; Biomarcadors; Microdissecció de captura làserAlzheimer's disease; Biomarkers; Laser capture microdissectionEnfermedad de Alzheimer; Biomarcadores; Microdisección por captura láserBrain accumulation of amyloid-beta (Aβ) is a crucial feature in Alzheimer´s disease (AD) and cerebral amyloid angiopathy (CAA), although the pathophysiological relationship between these diseases remains unclear. Numerous proteins are associated with Aβ deposited in parenchymal plaques and/or cerebral vessels. We hypothesized that the study of these proteins would increase our understanding of the overlap and biological differences between these two pathologies and may yield new diagnostic tools and specific therapeutic targets. We used a laser capture microdissection approach combined with mass spectrometry in the APP23 transgenic mouse model of cerebral-β-amyloidosis to specifically identify vascular Aβ-associated proteins. We focused on one of the main proteins detected in the Aβ-affected cerebrovasculature: MFG-E8 (milk fat globule-EGF factor 8), also known as lactadherin. We first validated the presence of MFG-E8 in mouse and human brains. Immunofluorescence and immunoblotting studies revealed that MFG-E8 brain levels were higher in APP23 mice than in WT mice. Furthermore, MFG-E8 was strongly detected in Aβ-positive vessels in human postmortem CAA brains, whereas MFG-E8 was not present in parenchymal Aβ deposits. Levels of MFG-E8 were additionally analysed in serum and cerebrospinal fluid (CSF) from patients diagnosed with CAA, patients with AD and control subjects. Whereas no differences were found in MFG-E8 serum levels between groups, MFG-E8 concentration was significantly lower in the CSF of CAA patients compared to controls and AD patients. Finally, in human vascular smooth muscle cells MFG-E8 was protective against the toxic effects of the treatment with the Aβ40 peptide containing the Dutch mutation. In summary, our study shows that MFG-E8 is highly associated with CAA pathology and highlights MFG-E8 as a new CSF biomarker that could potentially be used to differentiate cerebrovascular Aβ pathology from parenchymal Aβ deposition.This work was funded by the Instituto de Salud Carlos III (ISCIII), (PI20/00465), co-financed by the European Regional Development Fund (FEDER). The Neurovascular Research Laboratory is part of the INVICTUS + network, ISCIII, Spain (RD16/0019/0021). P.M. held a predoctoral fellowship from the Vall d’Hebron Research Institute. MMV is supported by the BIONIC project (no. 733050822, which has been made possible by ZonMW as part of ‘Memorabel’, the research and innovation program for dementia, as part of the Dutch national ‘Deltaplan for Dementia’:the CAFÉ project (the National Institutes of Health, USA, grant number 5R01NS104147-02), and a grant from the Selfridges Group Foundation (NR170024). The BIONIC project is a consortium of Radboudumc, LUMC, ADX Neurosciences, and Rhode Island University.BMCInstitut Català de la Salut[Marazuela P, Solé M, Bonaterra-Pastra A, Pizarro J, Delgado P, Hernández-Guillamon M] Laboratori de Recerca Neurovascular, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Camacho J, Martínez-Sáez E] Servei de Patologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Castillo-Ribelles L] Servei de Bioquímica Clínica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Pancorbo O, Rodríguez-Luna D] Unitat d’Ictus, Servei de Neurologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Pujadas F] Servei de Neurologia, Unitat de Demència, Vall d’Hebron Hospital Universitari, Barcelona, SpainVall d'Hebron Barcelona Hospital Campus202220222021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttps://hdl.handle.net/11351/7436http://hdl.handle.net/11351/7436Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésActa Neuropathologica Communications;9https://doi.org/10.1186/s40478-021-01257-9info:eu-repo/grantAgreement/ES/PE2017-2020/PI20%2F00465info:eu-repo/grantAgreement/ES/PE2013-2016/RD16%2F0019%2F0021Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/74362026-05-29T05:05:01Z
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