Conventional CD4+ T cells present bacterial antigens to induce cytotoxic and memory CD8+ T cell responses
Bacterial phagocytosis and antigen cross-presentation to activate CD8+ T cells are principal functions of professional antigen presenting cells. However, conventional CD4+ T cells also capture and kill bacteria from infected dendritic cells in a process termed transphagocytosis (also known as transi...
| Autores: | , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2017 |
| País: | España |
| Institución: | Instituto de Salud Carlos III (ISCIII) |
| Repositorio: | Repisalud |
| Idioma: | inglés |
| OAI Identifier: | oai:repisalud.isciii.es:20.500.12105/7229 |
| Acceso en línea: | http://hdl.handle.net/20.500.12105/7229 |
| Access Level: | acceso abierto |
| Palabra clave: | Animals Antigen Presentation Antigens, Bacterial CD4-Positive T-Lymphocytes CD8-Positive T-Lymphocytes Cells, Cultured Cross-Priming Cytotoxicity, Immunologic Immunologic Memory Immunological Synapses Mice, Inbred C57BL Mice, Transgenic Phagocytosis Programmed Cell Death 1 Receptor |
| Sumario: | Bacterial phagocytosis and antigen cross-presentation to activate CD8+ T cells are principal functions of professional antigen presenting cells. However, conventional CD4+ T cells also capture and kill bacteria from infected dendritic cells in a process termed transphagocytosis (also known as transinfection). Here, we show that transphagocytic T cells present bacterial antigens to naive CD8+ T cells, which proliferate and become cytotoxic in response. CD4+ T-cell-mediated antigen presentation also occurs in vivo in the course of infection, and induces the generation of central memory CD8+ T cells with low PD-1 expression. Moreover, transphagocytic CD4+ T cells induce protective anti-tumour immune responses by priming CD8+ T cells, highlighting the potential of CD4+ T cells as a tool for cancer immunotherapy. |
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