Cerebrospinal fluid cytokines in multiple system atrophy: A cross-sectional Catalan MSA registry study

Introduction Neuroinflammation is a potential player in neurodegenerative conditions, particularly the aggressive ones, such as multiple system atrophy (MSA). Previous reports on cytokine levels in MSA using serum or cerebrospinal fluid (CSF) have been inconsistent, including small samples and a lim...

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Autores: Compta, Yaroslau, Dias, Sara P., Giraldo, Darly M., Pérez Soriano, Alexandra, Muñoz, Esteban, Saura Martí, Josep, Fernández, Manel, Bravo, Paloma, Cámara, Ana, Pulido Salgado, Marta, Painous Martí, Cèlia, Rios, Jose, Martí Domènech, Ma. Josep, CMSAR consortium
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2019
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/227991
Acceso en línea:https://hdl.handle.net/2445/227991
Access Level:acceso abierto
Palabra clave:Marcadors bioquímics
Malaltia de Parkinson
Líquid cefalorraquidi
Biochemical markers
Parkinson's disease
Cerebrospinal fluid
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spelling Cerebrospinal fluid cytokines in multiple system atrophy: A cross-sectional Catalan MSA registry studyCompta, YaroslauDias, Sara P.Giraldo, Darly M.Pérez Soriano, AlexandraMuñoz, EstebanSaura Martí, JosepFernández, ManelBravo, PalomaCámara, AnaPulido Salgado, MartaPainous Martí, CèliaRios, JoseMartí Domènech, Ma. JosepCMSAR consortiumMarcadors bioquímicsMalaltia de ParkinsonLíquid cefalorraquidiBiochemical markersParkinson's diseaseCerebrospinal fluidIntroduction Neuroinflammation is a potential player in neurodegenerative conditions, particularly the aggressive ones, such as multiple system atrophy (MSA). Previous reports on cytokine levels in MSA using serum or cerebrospinal fluid (CSF) have been inconsistent, including small samples and a limited number of cytokines, often without comparison to Parkinson's disease (PD), a main MSA differential diagnosis. Methods Cross-sectional study of CSF levels of 38 cytokines using a multiplex assay in 73 participants: 39 MSA patients (19 with parkinsonian type [MSAp], 20 with cerebellar type [MSAc]; 31 probable, 8 possible), 19 PD patients and 15 neurologically unimpaired controls. None of the participants was under non-steroidal anti-inflammatory drugs at the time of the lumbar puncture. Results There were not significant differences in sex and age among participants. In global non-parametric comparisons FDR-corrected for multiple comparisons, CSF levels of 5 cytokines (FGF-2, IL-10, MCP-3, IL-12p40, MDC) differed among the three groups. In pair-wise FDR-corrected non-parametric comparisons 12 cytokines (FGF-2, eotaxin, fractalkine, IFN-α2, IL-10, MCP-3, IL-12p40, MDC, IL-17, IL-7, MIP-1β, TNF-α) were significantly higher in MSA vs. non-MSA cases (PD + controls pooled together). Of these, MCP-3 and MDC were the most significant ones, also differed in MSA vs. PD, and were significant MSA-predictors in binary logistic regression models and ROC curves adjusted for age. CSF levels of fractalkine and MIP-1α showed a strong and significant positive correlation with UMSARS-2 scores. Conclusion Increased CSF levels of cytokines such as MCP-3, MDC, fractalkine and MIP-1α deserve consideration as potential diagnostic or severity biomarkers of MSA.Elsevier B.V.2026202620192026info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion57 p.application/pdfhttps://hdl.handle.net/2445/227991Articles publicats en revistes (Biomedicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVersió postprint del document publicat a: https://doi.org/10.1016/j.parkreldis.2019.05.040Parkinsonism & Related Disorders, 2019, vol. 65, p. 3-12https://doi.org/10.1016/j.parkreldis.2019.05.040cc-by-nc-nd (c) Elsevier B.V., 2019http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2279912026-05-29T05:05:01Z
dc.title.none.fl_str_mv Cerebrospinal fluid cytokines in multiple system atrophy: A cross-sectional Catalan MSA registry study
title Cerebrospinal fluid cytokines in multiple system atrophy: A cross-sectional Catalan MSA registry study
spellingShingle Cerebrospinal fluid cytokines in multiple system atrophy: A cross-sectional Catalan MSA registry study
Compta, Yaroslau
Marcadors bioquímics
Malaltia de Parkinson
Líquid cefalorraquidi
Biochemical markers
Parkinson's disease
Cerebrospinal fluid
title_short Cerebrospinal fluid cytokines in multiple system atrophy: A cross-sectional Catalan MSA registry study
title_full Cerebrospinal fluid cytokines in multiple system atrophy: A cross-sectional Catalan MSA registry study
title_fullStr Cerebrospinal fluid cytokines in multiple system atrophy: A cross-sectional Catalan MSA registry study
title_full_unstemmed Cerebrospinal fluid cytokines in multiple system atrophy: A cross-sectional Catalan MSA registry study
title_sort Cerebrospinal fluid cytokines in multiple system atrophy: A cross-sectional Catalan MSA registry study
dc.creator.none.fl_str_mv Compta, Yaroslau
Dias, Sara P.
Giraldo, Darly M.
Pérez Soriano, Alexandra
Muñoz, Esteban
Saura Martí, Josep
Fernández, Manel
Bravo, Paloma
Cámara, Ana
Pulido Salgado, Marta
Painous Martí, Cèlia
Rios, Jose
Martí Domènech, Ma. Josep
CMSAR consortium
author Compta, Yaroslau
author_facet Compta, Yaroslau
Dias, Sara P.
Giraldo, Darly M.
Pérez Soriano, Alexandra
Muñoz, Esteban
Saura Martí, Josep
Fernández, Manel
Bravo, Paloma
Cámara, Ana
Pulido Salgado, Marta
Painous Martí, Cèlia
Rios, Jose
Martí Domènech, Ma. Josep
CMSAR consortium
author_role author
author2 Dias, Sara P.
Giraldo, Darly M.
Pérez Soriano, Alexandra
Muñoz, Esteban
Saura Martí, Josep
Fernández, Manel
Bravo, Paloma
Cámara, Ana
Pulido Salgado, Marta
Painous Martí, Cèlia
Rios, Jose
Martí Domènech, Ma. Josep
CMSAR consortium
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Marcadors bioquímics
Malaltia de Parkinson
Líquid cefalorraquidi
Biochemical markers
Parkinson's disease
Cerebrospinal fluid
topic Marcadors bioquímics
Malaltia de Parkinson
Líquid cefalorraquidi
Biochemical markers
Parkinson's disease
Cerebrospinal fluid
description Introduction Neuroinflammation is a potential player in neurodegenerative conditions, particularly the aggressive ones, such as multiple system atrophy (MSA). Previous reports on cytokine levels in MSA using serum or cerebrospinal fluid (CSF) have been inconsistent, including small samples and a limited number of cytokines, often without comparison to Parkinson's disease (PD), a main MSA differential diagnosis. Methods Cross-sectional study of CSF levels of 38 cytokines using a multiplex assay in 73 participants: 39 MSA patients (19 with parkinsonian type [MSAp], 20 with cerebellar type [MSAc]; 31 probable, 8 possible), 19 PD patients and 15 neurologically unimpaired controls. None of the participants was under non-steroidal anti-inflammatory drugs at the time of the lumbar puncture. Results There were not significant differences in sex and age among participants. In global non-parametric comparisons FDR-corrected for multiple comparisons, CSF levels of 5 cytokines (FGF-2, IL-10, MCP-3, IL-12p40, MDC) differed among the three groups. In pair-wise FDR-corrected non-parametric comparisons 12 cytokines (FGF-2, eotaxin, fractalkine, IFN-α2, IL-10, MCP-3, IL-12p40, MDC, IL-17, IL-7, MIP-1β, TNF-α) were significantly higher in MSA vs. non-MSA cases (PD + controls pooled together). Of these, MCP-3 and MDC were the most significant ones, also differed in MSA vs. PD, and were significant MSA-predictors in binary logistic regression models and ROC curves adjusted for age. CSF levels of fractalkine and MIP-1α showed a strong and significant positive correlation with UMSARS-2 scores. Conclusion Increased CSF levels of cytokines such as MCP-3, MDC, fractalkine and MIP-1α deserve consideration as potential diagnostic or severity biomarkers of MSA.
publishDate 2019
dc.date.none.fl_str_mv 2019
2026
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/227991
url https://hdl.handle.net/2445/227991
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1016/j.parkreldis.2019.05.040
Parkinsonism & Related Disorders, 2019, vol. 65, p. 3-12
https://doi.org/10.1016/j.parkreldis.2019.05.040
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Elsevier B.V., 2019
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Elsevier B.V., 2019
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 57 p.
application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv Articles publicats en revistes (Biomedicina)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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