Mycotoxin bioaccessibility/absorption assessment using in vitro digestion models: a review

In the evaluation of the oral bioavailability of a mycotoxin, the first step is the determination of its bioaccessibility, i.e. the percentage of mycotoxin released from the food matrix during digestion in the gastrointestinal (GI) tract that could be absorbed through the intestinal epithelium. Diff...

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Autores: González Arias, Cyndia A., Sanchís Almenar, Vicente, Ramos Girona, Antonio J.
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2013
País:España
Institución:Universitat de Lleida (UdL)
Repositorio:Repositori Obert UdL
OAI Identifier:oai:repositori.udl.cat:10459.1/59854
Acceso en línea:https://doi.org/10.3920/WMJ2012.1521
http://hdl.handle.net/10459.1/59854
Access Level:acceso abierto
Palabra clave:Masked mycotoxins
Bioaccessibility
Gastrointestinal simulation
In vitro models
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spelling Mycotoxin bioaccessibility/absorption assessment using in vitro digestion models: a reviewGonzález Arias, Cyndia A.Sanchís Almenar, VicenteRamos Girona, Antonio J.Masked mycotoxinsBioaccessibilityGastrointestinal simulationIn vitro modelsIn the evaluation of the oral bioavailability of a mycotoxin, the first step is the determination of its bioaccessibility, i.e. the percentage of mycotoxin released from the food matrix during digestion in the gastrointestinal (GI) tract that could be absorbed through the intestinal epithelium. Different in vitro digestion models have been recently used for determination of bioaccessibility, thereby avoiding the use of more complex cell culture techniques or the use of animals in expensive in vivo experiments. In vitro methods offer an appealing alternative to human and animal studies. They usually are rapid, simple and reasonably low in cost, and can be used to perform simplified experiments under uniform and well-controlled conditions, providing insights not achievable in whole animal studies. The available in vitro methods for GI simulation differ in the design of the system, the composition of the physiological juices assayed, as well as in the use or not of intestinal microbiota. There are models that only simulate the upper part of the GI tract (mouth-stomach-small intestine), whereas other methods include the large intestine, so that the model chosen could have some influence on the bioaccessibility data obtained. Bioaccessibility depends on the food matrix, as well as on the contamination level and the way the food/feed is contaminated (spiked or naturally). This review focuses on the currently available data regarding in vitro digestion models for the study of the ioaccessibility or absorption of mycotoxins, detailing the characteristics of each digestion step and the importance of the physiological juices employed during digestion. The effect that different factors play on mycotoxin release from the food matrix in the GI tract is also considered, and existing data on bioaccessibility of the main mycotoxins are given.The authors are grateful to CYTED Action 109AC0371, and the Spanish (Project AGL2011-24862) and Catalonian (XaRTA-Reference Network on Food Technology) Governments for their financial support. C.A. González- Arias thanks the Secretaria de Universitats i Recerca del Departament de Economia i Coneixement of the Generalitat de Catalunya for the pre-doctoral grant.Wageningen Academic Publishers2013info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionhttps://doi.org/10.3920/WMJ2012.1521http://hdl.handle.net/10459.1/59854reponame:Repositori Obert UdL instname:Universitat de Lleida (UdL)Inglésinfo:eu-repo/grantAgreement/MICINN//AGL2011-24862Versió postprint del document publicat a: https://doi.org/10.3920/WMJ2012.1521World Mycotoxin Journal, vol. 6, núm. 2, p. 167-184(c) Wageningen Academic Publishers, 2013info:eu-repo/semantics/openAccessoai:repositori.udl.cat:10459.1/598542026-06-24T12:42:17Z
dc.title.none.fl_str_mv Mycotoxin bioaccessibility/absorption assessment using in vitro digestion models: a review
title Mycotoxin bioaccessibility/absorption assessment using in vitro digestion models: a review
spellingShingle Mycotoxin bioaccessibility/absorption assessment using in vitro digestion models: a review
González Arias, Cyndia A.
Masked mycotoxins
Bioaccessibility
Gastrointestinal simulation
In vitro models
title_short Mycotoxin bioaccessibility/absorption assessment using in vitro digestion models: a review
title_full Mycotoxin bioaccessibility/absorption assessment using in vitro digestion models: a review
title_fullStr Mycotoxin bioaccessibility/absorption assessment using in vitro digestion models: a review
title_full_unstemmed Mycotoxin bioaccessibility/absorption assessment using in vitro digestion models: a review
title_sort Mycotoxin bioaccessibility/absorption assessment using in vitro digestion models: a review
dc.creator.none.fl_str_mv González Arias, Cyndia A.
Sanchís Almenar, Vicente
Ramos Girona, Antonio J.
author González Arias, Cyndia A.
author_facet González Arias, Cyndia A.
Sanchís Almenar, Vicente
Ramos Girona, Antonio J.
author_role author
author2 Sanchís Almenar, Vicente
Ramos Girona, Antonio J.
author2_role author
author
dc.subject.none.fl_str_mv Masked mycotoxins
Bioaccessibility
Gastrointestinal simulation
In vitro models
topic Masked mycotoxins
Bioaccessibility
Gastrointestinal simulation
In vitro models
description In the evaluation of the oral bioavailability of a mycotoxin, the first step is the determination of its bioaccessibility, i.e. the percentage of mycotoxin released from the food matrix during digestion in the gastrointestinal (GI) tract that could be absorbed through the intestinal epithelium. Different in vitro digestion models have been recently used for determination of bioaccessibility, thereby avoiding the use of more complex cell culture techniques or the use of animals in expensive in vivo experiments. In vitro methods offer an appealing alternative to human and animal studies. They usually are rapid, simple and reasonably low in cost, and can be used to perform simplified experiments under uniform and well-controlled conditions, providing insights not achievable in whole animal studies. The available in vitro methods for GI simulation differ in the design of the system, the composition of the physiological juices assayed, as well as in the use or not of intestinal microbiota. There are models that only simulate the upper part of the GI tract (mouth-stomach-small intestine), whereas other methods include the large intestine, so that the model chosen could have some influence on the bioaccessibility data obtained. Bioaccessibility depends on the food matrix, as well as on the contamination level and the way the food/feed is contaminated (spiked or naturally). This review focuses on the currently available data regarding in vitro digestion models for the study of the ioaccessibility or absorption of mycotoxins, detailing the characteristics of each digestion step and the importance of the physiological juices employed during digestion. The effect that different factors play on mycotoxin release from the food matrix in the GI tract is also considered, and existing data on bioaccessibility of the main mycotoxins are given.
publishDate 2013
dc.date.none.fl_str_mv 2013
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.3920/WMJ2012.1521
http://hdl.handle.net/10459.1/59854
url https://doi.org/10.3920/WMJ2012.1521
http://hdl.handle.net/10459.1/59854
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/MICINN//AGL2011-24862
Versió postprint del document publicat a: https://doi.org/10.3920/WMJ2012.1521
World Mycotoxin Journal, vol. 6, núm. 2, p. 167-184
dc.rights.none.fl_str_mv (c) Wageningen Academic Publishers, 2013
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Wageningen Academic Publishers, 2013
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wageningen Academic Publishers
publisher.none.fl_str_mv Wageningen Academic Publishers
dc.source.none.fl_str_mv reponame:Repositori Obert UdL
instname:Universitat de Lleida (UdL)
instname_str Universitat de Lleida (UdL)
reponame_str Repositori Obert UdL
collection Repositori Obert UdL
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