Traumatic Brain Injury and Acute Kidney Injury-Outcomes and Associated Risk Factors

Our objective was to analyze the contribution of acute kidney injury (AKI) to the mortality of isolated TBI patients and its associated risk factors. Observational, prospective and multicenter registry (RETRAUCI) methods were used, from March 2015 to December 2019. Isolated TBI was defined as abbrev...

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Autores: Barea-Mendoza, Jesús Abelardo, Chico-Fernández, Mario, Quintana-Díaz, Manuel, Servià Goixart, Lluís, Fernández-Cuervo, Ana, Bringas-Bollada, María, Ballesteros Sanz, María Ángeles, García-Sáez, Íker, Pérez-Bárcena, Jon, Llompart-Pou, Juan Antonio
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Universitat de Lleida (UdL)
Repositorio:Repositori Obert UdL
OAI Identifier:oai:repositori.udl.cat:10459.1/463920
Acceso en línea:https://doi.org/10.3390/jcm11237216
https://hdl.handle.net/10459.1/463920
Access Level:acceso abierto
Palabra clave:Traumatic brain injury
Severe trauma
Acute kidney injury
Intensive care
Mortality
RETRAUCI
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spelling Traumatic Brain Injury and Acute Kidney Injury-Outcomes and Associated Risk FactorsBarea-Mendoza, Jesús AbelardoChico-Fernández, MarioQuintana-Díaz, ManuelServià Goixart, LluísFernández-Cuervo, AnaBringas-Bollada, MaríaBallesteros Sanz, María ÁngelesGarcía-Sáez, ÍkerPérez-Bárcena, JonLlompart-Pou, Juan AntonioTraumatic brain injurySevere traumaAcute kidney injuryIntensive careMortalityRETRAUCIOur objective was to analyze the contribution of acute kidney injury (AKI) to the mortality of isolated TBI patients and its associated risk factors. Observational, prospective and multicenter registry (RETRAUCI) methods were used, from March 2015 to December 2019. Isolated TBI was defined as abbreviated injury scale (AIS) ≥ 3 head with no additional score ≥ 3. A comparison of groups was conducted using the Wilcoxon test, chi-square test or Fisher's exact test, as appropriate. A multiple logistic regression analysis was conducted to analyze associated risk factors in the development of AKI. For the result, overall, 2964 (30.2%) had AIS head ≥ 3 with no other area with AIS ≥ 3. The mean age was 54.7 (SD 19.5) years, 76% were men, and the ground-level falls was 49.1%. The mean ISS was 18.4 (SD 8). The in-hospital mortality was 22.2%. Up to 310 patients (10.6%) developed AKI, which was associated with increased mortality (39% vs. 17%, adjusted OR 2.2). Associated risk factors (odds ratio (OR) (95% confidence interval)) were age (OR 1.02 (1.01-1.02)), hemodynamic instability (OR 2.87 to OR 5.83 (1.79-13.1)), rhabdomyolysis (OR 2.94 (1.69-5.11)), trauma-associated coagulopathy (OR 1.67 (1.05-2.66)) and transfusion of packed red-blood-cell concentrates (OR 1.76 (1.12-2.76)). In conclusion, AKI occurred in 10.6% of isolated TBI patients and was associated with increased mortality.MDPI2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.3390/jcm11237216https://hdl.handle.net/10459.1/463920reponame:Repositori Obert UdL instname:Universitat de Lleida (UdL)InglésReproducció del document publicat a: https://doi.org/10.3390/jcm11237216Journal Of Clinical Medicine, 2022, vol. 11, núm. 23cc-by (c) The authors, 2022info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/4.0oai:repositori.udl.cat:10459.1/4639202026-06-24T12:42:17Z
dc.title.none.fl_str_mv Traumatic Brain Injury and Acute Kidney Injury-Outcomes and Associated Risk Factors
title Traumatic Brain Injury and Acute Kidney Injury-Outcomes and Associated Risk Factors
spellingShingle Traumatic Brain Injury and Acute Kidney Injury-Outcomes and Associated Risk Factors
Barea-Mendoza, Jesús Abelardo
Traumatic brain injury
Severe trauma
Acute kidney injury
Intensive care
Mortality
RETRAUCI
title_short Traumatic Brain Injury and Acute Kidney Injury-Outcomes and Associated Risk Factors
title_full Traumatic Brain Injury and Acute Kidney Injury-Outcomes and Associated Risk Factors
title_fullStr Traumatic Brain Injury and Acute Kidney Injury-Outcomes and Associated Risk Factors
title_full_unstemmed Traumatic Brain Injury and Acute Kidney Injury-Outcomes and Associated Risk Factors
title_sort Traumatic Brain Injury and Acute Kidney Injury-Outcomes and Associated Risk Factors
dc.creator.none.fl_str_mv Barea-Mendoza, Jesús Abelardo
Chico-Fernández, Mario
Quintana-Díaz, Manuel
Servià Goixart, Lluís
Fernández-Cuervo, Ana
Bringas-Bollada, María
Ballesteros Sanz, María Ángeles
García-Sáez, Íker
Pérez-Bárcena, Jon
Llompart-Pou, Juan Antonio
author Barea-Mendoza, Jesús Abelardo
author_facet Barea-Mendoza, Jesús Abelardo
Chico-Fernández, Mario
Quintana-Díaz, Manuel
Servià Goixart, Lluís
Fernández-Cuervo, Ana
Bringas-Bollada, María
Ballesteros Sanz, María Ángeles
García-Sáez, Íker
Pérez-Bárcena, Jon
Llompart-Pou, Juan Antonio
author_role author
author2 Chico-Fernández, Mario
Quintana-Díaz, Manuel
Servià Goixart, Lluís
Fernández-Cuervo, Ana
Bringas-Bollada, María
Ballesteros Sanz, María Ángeles
García-Sáez, Íker
Pérez-Bárcena, Jon
Llompart-Pou, Juan Antonio
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Traumatic brain injury
Severe trauma
Acute kidney injury
Intensive care
Mortality
RETRAUCI
topic Traumatic brain injury
Severe trauma
Acute kidney injury
Intensive care
Mortality
RETRAUCI
description Our objective was to analyze the contribution of acute kidney injury (AKI) to the mortality of isolated TBI patients and its associated risk factors. Observational, prospective and multicenter registry (RETRAUCI) methods were used, from March 2015 to December 2019. Isolated TBI was defined as abbreviated injury scale (AIS) ≥ 3 head with no additional score ≥ 3. A comparison of groups was conducted using the Wilcoxon test, chi-square test or Fisher's exact test, as appropriate. A multiple logistic regression analysis was conducted to analyze associated risk factors in the development of AKI. For the result, overall, 2964 (30.2%) had AIS head ≥ 3 with no other area with AIS ≥ 3. The mean age was 54.7 (SD 19.5) years, 76% were men, and the ground-level falls was 49.1%. The mean ISS was 18.4 (SD 8). The in-hospital mortality was 22.2%. Up to 310 patients (10.6%) developed AKI, which was associated with increased mortality (39% vs. 17%, adjusted OR 2.2). Associated risk factors (odds ratio (OR) (95% confidence interval)) were age (OR 1.02 (1.01-1.02)), hemodynamic instability (OR 2.87 to OR 5.83 (1.79-13.1)), rhabdomyolysis (OR 2.94 (1.69-5.11)), trauma-associated coagulopathy (OR 1.67 (1.05-2.66)) and transfusion of packed red-blood-cell concentrates (OR 1.76 (1.12-2.76)). In conclusion, AKI occurred in 10.6% of isolated TBI patients and was associated with increased mortality.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.3390/jcm11237216
https://hdl.handle.net/10459.1/463920
url https://doi.org/10.3390/jcm11237216
https://hdl.handle.net/10459.1/463920
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/jcm11237216
Journal Of Clinical Medicine, 2022, vol. 11, núm. 23
dc.rights.none.fl_str_mv cc-by (c) The authors, 2022
info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/4.0
rights_invalid_str_mv cc-by (c) The authors, 2022
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositori Obert UdL
instname:Universitat de Lleida (UdL)
instname_str Universitat de Lleida (UdL)
reponame_str Repositori Obert UdL
collection Repositori Obert UdL
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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