The importance of maternal insulin resistance throughout pregnancy on neonatal adiposity

Background Although previous studies evaluated the association of maternal health parameters with neonatal adiposity, little is known regarding the complexity of the relationships among different maternal health parameters throughout pregnancy and its impact on neonatal adiposity. Objectives To eval...

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Autores: Lima, RA, Desoye, G, Simmons, D, Devlieger, R, Galjaard, S, Corcoy, R, Adelantado, JM, Dunne, F, Harreiter, J, Kautzky-Willer, A, Damm, P, Mathiesen, ER, Jensen, DM, Andersen, LLT, Tanvig, M, Lapolla, A, Dalfra, MG, Bertolotto, A, Manta, U, Wender-Ozegowska, E, Zawiejska, A, Hill, DJ, Snoek, FJ, Jelsma, JGM, van Poppel, M
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2021
País:España
Recursos:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositório:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p7974
Acesso em linha:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=7974
https://ddd.uab.cat/record/272151
Access Level:Acceso aberto
Palavra-chave:endocrinology
gynaecology
insulin
lipid metabolism
obesity
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spelling The importance of maternal insulin resistance throughout pregnancy on neonatal adiposityLima, RADesoye, GSimmons, DDevlieger, RGaljaard, SCorcoy, RAdelantado, JMDunne, FHarreiter, JKautzky-Willer, ADamm, PMathiesen, ERJensen, DMAndersen, LLTTanvig, MLapolla, ADalfra, MGBertolotto, AManta, UWender-Ozegowska, EZawiejska, AHill, DJSnoek, FJJelsma, JGMvan Poppel, Mendocrinologygynaecologyinsulinlipid metabolismobesityBackground Although previous studies evaluated the association of maternal health parameters with neonatal adiposity, little is known regarding the complexity of the relationships among different maternal health parameters throughout pregnancy and its impact on neonatal adiposity. Objectives To evaluate the direct and indirect associations between maternal insulin resistance during pregnancy, in women with obesity, and neonatal adiposity. In addition, associations between maternal fasting glucose, triglycerides (TG), non-esterified fatty acids (NEFA), and neonatal adiposity were also assessed. Methods This is a longitudinal, secondary analysis of the DALI study, an international project conducted in nine European countries with pregnant women with obesity. Maternal insulin resistance (HOMA-IR), fasting glucose, TG, and NEFA were measured three times during pregnancy (<20, 24-28, and 35-37 weeks of gestation). Offspring neonatal adiposity was estimated by the sum of four skinfolds. Structural equation modelling was conducted to evaluate the direct and indirect relationships among the variables of interest. Results Data on 657 mother-infant pairs (50.7% boys) were analysed. Neonatal boys exhibited lower mean sum of skinfolds compared to girls (20.3 mm, 95% CI 19.7, 21.0 vs 21.5 mm, 95% CI 20.8, 22.2). In boys, maternal HOMA-IR at <20 weeks was directly associated with neonatal adiposity (beta = 0.35 mm, 95% CI 0.01, 0.70). In girls, maternal HOMA-IR at 24-28 weeks was only indirectly associated with neonatal adiposity, which implies that this association was mediated via maternal HOMA-IR, glucose, triglycerides, and NEFA during pregnancy (beta = 0.26 mm, 95% CI 0.08, 0.44). Conclusions The timing of the role of maternal insulin resistance on neonatal adiposity depends on fetal sex. Although the association was time-dependent, maternal insulin resistance was associated with neonatal adiposity in both sexes.WILEY2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=7974https://ddd.uab.cat/record/272151PAEDIATRIC AND PERINATAL EPIDEMIOLOGYISSN: 02695022ISSNe: 13653016reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p79742026-06-14T12:41:47Z
dc.title.none.fl_str_mv The importance of maternal insulin resistance throughout pregnancy on neonatal adiposity
title The importance of maternal insulin resistance throughout pregnancy on neonatal adiposity
spellingShingle The importance of maternal insulin resistance throughout pregnancy on neonatal adiposity
Lima, RA
endocrinology
gynaecology
insulin
lipid metabolism
obesity
title_short The importance of maternal insulin resistance throughout pregnancy on neonatal adiposity
title_full The importance of maternal insulin resistance throughout pregnancy on neonatal adiposity
title_fullStr The importance of maternal insulin resistance throughout pregnancy on neonatal adiposity
title_full_unstemmed The importance of maternal insulin resistance throughout pregnancy on neonatal adiposity
title_sort The importance of maternal insulin resistance throughout pregnancy on neonatal adiposity
dc.creator.none.fl_str_mv Lima, RA
Desoye, G
Simmons, D
Devlieger, R
Galjaard, S
Corcoy, R
Adelantado, JM
Dunne, F
Harreiter, J
Kautzky-Willer, A
Damm, P
Mathiesen, ER
Jensen, DM
Andersen, LLT
Tanvig, M
Lapolla, A
Dalfra, MG
Bertolotto, A
Manta, U
Wender-Ozegowska, E
Zawiejska, A
Hill, DJ
Snoek, FJ
Jelsma, JGM
van Poppel, M
author Lima, RA
author_facet Lima, RA
Desoye, G
Simmons, D
Devlieger, R
Galjaard, S
Corcoy, R
Adelantado, JM
Dunne, F
Harreiter, J
Kautzky-Willer, A
Damm, P
Mathiesen, ER
Jensen, DM
Andersen, LLT
Tanvig, M
Lapolla, A
Dalfra, MG
Bertolotto, A
Manta, U
Wender-Ozegowska, E
Zawiejska, A
Hill, DJ
Snoek, FJ
Jelsma, JGM
van Poppel, M
author_role author
author2 Desoye, G
Simmons, D
Devlieger, R
Galjaard, S
Corcoy, R
Adelantado, JM
Dunne, F
Harreiter, J
Kautzky-Willer, A
Damm, P
Mathiesen, ER
Jensen, DM
Andersen, LLT
Tanvig, M
Lapolla, A
Dalfra, MG
Bertolotto, A
Manta, U
Wender-Ozegowska, E
Zawiejska, A
Hill, DJ
Snoek, FJ
Jelsma, JGM
van Poppel, M
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv endocrinology
gynaecology
insulin
lipid metabolism
obesity
topic endocrinology
gynaecology
insulin
lipid metabolism
obesity
description Background Although previous studies evaluated the association of maternal health parameters with neonatal adiposity, little is known regarding the complexity of the relationships among different maternal health parameters throughout pregnancy and its impact on neonatal adiposity. Objectives To evaluate the direct and indirect associations between maternal insulin resistance during pregnancy, in women with obesity, and neonatal adiposity. In addition, associations between maternal fasting glucose, triglycerides (TG), non-esterified fatty acids (NEFA), and neonatal adiposity were also assessed. Methods This is a longitudinal, secondary analysis of the DALI study, an international project conducted in nine European countries with pregnant women with obesity. Maternal insulin resistance (HOMA-IR), fasting glucose, TG, and NEFA were measured three times during pregnancy (<20, 24-28, and 35-37 weeks of gestation). Offspring neonatal adiposity was estimated by the sum of four skinfolds. Structural equation modelling was conducted to evaluate the direct and indirect relationships among the variables of interest. Results Data on 657 mother-infant pairs (50.7% boys) were analysed. Neonatal boys exhibited lower mean sum of skinfolds compared to girls (20.3 mm, 95% CI 19.7, 21.0 vs 21.5 mm, 95% CI 20.8, 22.2). In boys, maternal HOMA-IR at <20 weeks was directly associated with neonatal adiposity (beta = 0.35 mm, 95% CI 0.01, 0.70). In girls, maternal HOMA-IR at 24-28 weeks was only indirectly associated with neonatal adiposity, which implies that this association was mediated via maternal HOMA-IR, glucose, triglycerides, and NEFA during pregnancy (beta = 0.26 mm, 95% CI 0.08, 0.44). Conclusions The timing of the role of maternal insulin resistance on neonatal adiposity depends on fetal sex. Although the association was time-dependent, maternal insulin resistance was associated with neonatal adiposity in both sexes.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=7974
https://ddd.uab.cat/record/272151
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=7974
https://ddd.uab.cat/record/272151
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv WILEY
publisher.none.fl_str_mv WILEY
dc.source.none.fl_str_mv PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
ISSN: 02695022
ISSNe: 13653016
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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