Epigenome-Wide Association Study in Peripheral Tissues Highlights DNA Methylation Profiles Associated with Episodic Memory Performance in Humans

The decline in episodic memory (EM) performance is a hallmark of cognitive aging and an early clinical sign in Alzheimer's disease (AD). In this study, we conducted an epigenome-wide association study (EWAS) using DNA methylation (DNAm) profiles from buccal and blood samples for cross-sectional...

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Autores: Sommerer, Yasmine|||0000-0003-2323-9340, Dobricic, Valerija|||0000-0001-8559-1097, Schilling, Marcel|||0000-0002-3453-7792, Ohlei, Olena, Bartrés-Faz, David|||0000-0001-6020-4118, Cattaneo, Gabriele|||0000-0002-7411-6829, Demuth, Ilja, Düzel, Sandra, Franzenburg, Sören, Fuß, Janina|||0000-0002-7631-9355, Lindenberger, Ulman, Pascual Leone, Álvaro|||0000-0001-8975-0382, Sabet, Sanaz Sedghpour, Solé-Padullés, Cristina|||0000-0002-6653-1053, Tormos, Jose M.|||0000-0002-8764-2289, Vetter, Valentin Max|||0000-0001-5003-7766, Wesse, Tanja, Franke, Andre|||0000-0003-1530-5811, Lill, Christina|||0000-0002-2805-1307, Bertram, Lars|||0000-0002-0108-124X
Tipo de documento: artigo
Data de publicação:2022
País:España
Recursos:Universitat Autònoma de Barcelona
Repositório:Dipòsit Digital de Documents de la UAB
Idioma:inglês
OAI Identifier:oai:ddd.uab.cat:281792
Acesso em linha:https://ddd.uab.cat/record/281792
https://dx.doi.org/urn:doi:10.3390/biomedicines10112798
Access Level:Acceso aberto
Palavra-chave:CpG
Cross-sectional
DNA methylation
Epigenome-wide association study
Episodic memory
EWAS
Longitudinal
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oai_identifier_str oai:ddd.uab.cat:281792
network_acronym_str ES
network_name_str España
repository_id_str
spelling Epigenome-Wide Association Study in Peripheral Tissues Highlights DNA Methylation Profiles Associated with Episodic Memory Performance in HumansSommerer, Yasmine|||0000-0003-2323-9340Dobricic, Valerija|||0000-0001-8559-1097Schilling, Marcel|||0000-0002-3453-7792Ohlei, OlenaBartrés-Faz, David|||0000-0001-6020-4118Cattaneo, Gabriele|||0000-0002-7411-6829Demuth, IljaDüzel, SandraFranzenburg, SörenFuß, Janina|||0000-0002-7631-9355Lindenberger, UlmanPascual Leone, Álvaro|||0000-0001-8975-0382Sabet, Sanaz SedghpourSolé-Padullés, Cristina|||0000-0002-6653-1053Tormos, Jose M.|||0000-0002-8764-2289Vetter, Valentin Max|||0000-0001-5003-7766Wesse, TanjaFranke, Andre|||0000-0003-1530-5811Lill, Christina|||0000-0002-2805-1307Bertram, Lars|||0000-0002-0108-124XCpGCross-sectionalDNA methylationEpigenome-wide association studyEpisodic memoryEWASLongitudinalThe decline in episodic memory (EM) performance is a hallmark of cognitive aging and an early clinical sign in Alzheimer's disease (AD). In this study, we conducted an epigenome-wide association study (EWAS) using DNA methylation (DNAm) profiles from buccal and blood samples for cross-sectional (n = 1019) and longitudinal changes in EM performance (n = 626; average follow-up time 5.4 years) collected under the auspices of the Lifebrain consortium project. The mean age of participants with cross-sectional data was 69 ± 11 years (30-90 years), with 50% being females. We identified 21 loci showing suggestive evidence of association (p < 1 × 10 -5) with either or both EM phenotypes. Among these were SNCA, SEPW1 (both cross-sectional EM), ITPK1 (longitudinal EM), and APBA2 (both EM traits), which have been linked to AD or Parkinson's disease (PD) in previous work. While the EM phenotypes were nominally significantly (p < 0.05) associated with poly-epigenetic scores (PESs) using EWASs on general cognitive function, none remained significant after correction for multiple testing. Likewise, estimating the degree of "epigenetic age acceleration" did not reveal significant associations with either of the two tested EM phenotypes. In summary, our study highlights several interesting candidate loci in which differential DNAm patterns in peripheral tissue are associated with EM performance in humans.Universitat Autònoma de Barcelona 22022-01-0120222022-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/281792https://dx.doi.org/urn:doi:10.3390/biomedicines10112798reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2817922026-06-06T12:50:31Z
dc.title.none.fl_str_mv Epigenome-Wide Association Study in Peripheral Tissues Highlights DNA Methylation Profiles Associated with Episodic Memory Performance in Humans
title Epigenome-Wide Association Study in Peripheral Tissues Highlights DNA Methylation Profiles Associated with Episodic Memory Performance in Humans
spellingShingle Epigenome-Wide Association Study in Peripheral Tissues Highlights DNA Methylation Profiles Associated with Episodic Memory Performance in Humans
Sommerer, Yasmine|||0000-0003-2323-9340
CpG
Cross-sectional
DNA methylation
Epigenome-wide association study
Episodic memory
EWAS
Longitudinal
title_short Epigenome-Wide Association Study in Peripheral Tissues Highlights DNA Methylation Profiles Associated with Episodic Memory Performance in Humans
title_full Epigenome-Wide Association Study in Peripheral Tissues Highlights DNA Methylation Profiles Associated with Episodic Memory Performance in Humans
title_fullStr Epigenome-Wide Association Study in Peripheral Tissues Highlights DNA Methylation Profiles Associated with Episodic Memory Performance in Humans
title_full_unstemmed Epigenome-Wide Association Study in Peripheral Tissues Highlights DNA Methylation Profiles Associated with Episodic Memory Performance in Humans
title_sort Epigenome-Wide Association Study in Peripheral Tissues Highlights DNA Methylation Profiles Associated with Episodic Memory Performance in Humans
dc.creator.none.fl_str_mv Sommerer, Yasmine|||0000-0003-2323-9340
Dobricic, Valerija|||0000-0001-8559-1097
Schilling, Marcel|||0000-0002-3453-7792
Ohlei, Olena
Bartrés-Faz, David|||0000-0001-6020-4118
Cattaneo, Gabriele|||0000-0002-7411-6829
Demuth, Ilja
Düzel, Sandra
Franzenburg, Sören
Fuß, Janina|||0000-0002-7631-9355
Lindenberger, Ulman
Pascual Leone, Álvaro|||0000-0001-8975-0382
Sabet, Sanaz Sedghpour
Solé-Padullés, Cristina|||0000-0002-6653-1053
Tormos, Jose M.|||0000-0002-8764-2289
Vetter, Valentin Max|||0000-0001-5003-7766
Wesse, Tanja
Franke, Andre|||0000-0003-1530-5811
Lill, Christina|||0000-0002-2805-1307
Bertram, Lars|||0000-0002-0108-124X
author Sommerer, Yasmine|||0000-0003-2323-9340
author_facet Sommerer, Yasmine|||0000-0003-2323-9340
Dobricic, Valerija|||0000-0001-8559-1097
Schilling, Marcel|||0000-0002-3453-7792
Ohlei, Olena
Bartrés-Faz, David|||0000-0001-6020-4118
Cattaneo, Gabriele|||0000-0002-7411-6829
Demuth, Ilja
Düzel, Sandra
Franzenburg, Sören
Fuß, Janina|||0000-0002-7631-9355
Lindenberger, Ulman
Pascual Leone, Álvaro|||0000-0001-8975-0382
Sabet, Sanaz Sedghpour
Solé-Padullés, Cristina|||0000-0002-6653-1053
Tormos, Jose M.|||0000-0002-8764-2289
Vetter, Valentin Max|||0000-0001-5003-7766
Wesse, Tanja
Franke, Andre|||0000-0003-1530-5811
Lill, Christina|||0000-0002-2805-1307
Bertram, Lars|||0000-0002-0108-124X
author_role author
author2 Dobricic, Valerija|||0000-0001-8559-1097
Schilling, Marcel|||0000-0002-3453-7792
Ohlei, Olena
Bartrés-Faz, David|||0000-0001-6020-4118
Cattaneo, Gabriele|||0000-0002-7411-6829
Demuth, Ilja
Düzel, Sandra
Franzenburg, Sören
Fuß, Janina|||0000-0002-7631-9355
Lindenberger, Ulman
Pascual Leone, Álvaro|||0000-0001-8975-0382
Sabet, Sanaz Sedghpour
Solé-Padullés, Cristina|||0000-0002-6653-1053
Tormos, Jose M.|||0000-0002-8764-2289
Vetter, Valentin Max|||0000-0001-5003-7766
Wesse, Tanja
Franke, Andre|||0000-0003-1530-5811
Lill, Christina|||0000-0002-2805-1307
Bertram, Lars|||0000-0002-0108-124X
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv CpG
Cross-sectional
DNA methylation
Epigenome-wide association study
Episodic memory
EWAS
Longitudinal
topic CpG
Cross-sectional
DNA methylation
Epigenome-wide association study
Episodic memory
EWAS
Longitudinal
description The decline in episodic memory (EM) performance is a hallmark of cognitive aging and an early clinical sign in Alzheimer's disease (AD). In this study, we conducted an epigenome-wide association study (EWAS) using DNA methylation (DNAm) profiles from buccal and blood samples for cross-sectional (n = 1019) and longitudinal changes in EM performance (n = 626; average follow-up time 5.4 years) collected under the auspices of the Lifebrain consortium project. The mean age of participants with cross-sectional data was 69 ± 11 years (30-90 years), with 50% being females. We identified 21 loci showing suggestive evidence of association (p < 1 × 10 -5) with either or both EM phenotypes. Among these were SNCA, SEPW1 (both cross-sectional EM), ITPK1 (longitudinal EM), and APBA2 (both EM traits), which have been linked to AD or Parkinson's disease (PD) in previous work. While the EM phenotypes were nominally significantly (p < 0.05) associated with poly-epigenetic scores (PESs) using EWASs on general cognitive function, none remained significant after correction for multiple testing. Likewise, estimating the degree of "epigenetic age acceleration" did not reveal significant associations with either of the two tested EM phenotypes. In summary, our study highlights several interesting candidate loci in which differential DNAm patterns in peripheral tissue are associated with EM performance in humans.
publishDate 2022
dc.date.none.fl_str_mv 2
2022-01-01
2022
2022-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/281792
https://dx.doi.org/urn:doi:10.3390/biomedicines10112798
url https://ddd.uab.cat/record/281792
https://dx.doi.org/urn:doi:10.3390/biomedicines10112798
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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