Falls Predict Acute Hospitalization in Parkinson's Disease.

Santos García D; de Deus Fonticoba T; Cores C; Castro ES; Hernández Vara J; Jesús S; Mir P; Cosgaya M; Martí MJ; Pastor P; Cabo I; Seijo M; Legarda I; Vives B; Caballol N; Rúiz Martínez J; Croitoru I; Cubo E; Miranda J; Alonso Losada MG; Labandeira C; López Ariztegui N; Morales-Casado M; González Aramburu I; Infante J; Escalante S; Bernardo N; Blázquez Estrada M; Menéndez González M; Caldentey JG; Borrué C; Vela L; Catalán MJ; Gómez Mayordomo V; Kurtis M; Prieto C; Ordás C; Nogueira V; López Manzanares L; Ávila Rivera MA; Puente V; García Moreno JM; Solano Vila B; Álvarez Sauco M; Carrillo Padilla F; Carlos Martínez Castrillo J; Sánchez Alonso P; Gastón I; Kulisevsky J; Valero C; de Fábregues O; González Ardura J; López Díaz LM; Martinez-Martin P

Falls Predict Acute Hospitalization in Parkinson's Disease.

BACKGROUND: There is a need for identifying risk factors for hospitalization in Parkinson's disease (PD) and also interventions to reduce acute hospital admission. OBJECTIVE: To analyze the frequency, causes, and predictors of acute hospitalization (AH) in PD patients from a Spanish cohort. MET...

Descripción completa

Detalles Bibliográficos
Autores:	Santos García D, de Deus Fonticoba T, Cores C, Castro ES, Hernández Vara J, Jesús S, Mir P, Cosgaya M, Martí MJ, Pastor P, Cabo I, Seijo M, Legarda I, Vives B, Caballol N, Rúiz Martínez J, Croitoru I, Cubo E, Miranda J, Alonso Losada MG, Labandeira C, López Ariztegui N, Morales-Casado M, González Aramburu I, Infante J, Escalante S, Bernardo N, Blázquez Estrada M, Menéndez González M, Caldentey JG, Borrué C, Vela L, Catalán MJ, Gómez Mayordomo V, Kurtis M, Prieto C, Ordás C, Nogueira V, López Manzanares L, Ávila Rivera MA, Puente V, García Moreno JM, Solano Vila B, Álvarez Sauco M, Carrillo Padilla F, Carlos Martínez Castrillo J, Sánchez Alonso P, Gastón I, Kulisevsky J, Valero C, de Fábregues O, González Ardura J, López Díaz LM, Martinez-Martin P
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2023
País:	España
Institución:	Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:	r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:	oai:iibsantpau.fundanetsuite.com:p7998
Acceso en línea:	https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=7998 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85147458316&doi=10.3233%2fJPD-212539&partnerID=40&md5=aab9777234d9f689ad22e24f85dd5381
Access Level:	acceso abierto
Palabra clave:	levodopa aged complication female human male middle aged Parkinson disease proportional hazards model risk factor Spain Aged Female Humans Levodopa Male Middle Aged Parkinson Disease Proportional Hazards Models Risk Factors

id	ES_f8f4fd39076f4f05052cd016448c4b3c
oai_identifier_str	oai:iibsantpau.fundanetsuite.com:p7998
network_acronym_str	ES
network_name_str	España
repository_id_str
spelling	Falls Predict Acute Hospitalization in Parkinson's Disease.Santos García Dde Deus Fonticoba TCores CCastro ESHernández Vara JJesús SMir PCosgaya MMartí MJPastor PCabo ISeijo MLegarda IVives BCaballol NRúiz Martínez JCroitoru ICubo EMiranda JAlonso Losada MGLabandeira CLópez Ariztegui NMorales-Casado MGonzález Aramburu IInfante JEscalante SBernardo NBlázquez Estrada MMenéndez González MCaldentey JGBorrué CVela LCatalán MJGómez Mayordomo VKurtis MPrieto COrdás CNogueira VLópez Manzanares LÁvila Rivera MAPuente VGarcía Moreno JMSolano Vila BÁlvarez Sauco MCarrillo Padilla FCarlos Martínez Castrillo JSánchez Alonso PGastón IKulisevsky JValero Cde Fábregues OGonzález Ardura JLópez Díaz LMMartinez-Martin Plevodopaagedcomplicationfemalehumanmalemiddle agedParkinson diseaseproportional hazards modelrisk factorSpainAgedFemaleHumansLevodopaMaleMiddle AgedParkinson DiseaseProportional Hazards ModelsRisk FactorsSpainBACKGROUND: There is a need for identifying risk factors for hospitalization in Parkinson's disease (PD) and also interventions to reduce acute hospital admission. OBJECTIVE: To analyze the frequency, causes, and predictors of acute hospitalization (AH) in PD patients from a Spanish cohort. METHODS: PD patients recruited from 35 centers of Spain from the COPPADIS-2015 (COhort of Patients with PArkinson's DIsease in Spain, 2015) cohort from January 2016 to November 2017, were included in the study. In order to identify predictors of AH, Kaplan-Meier estimates of factors considered as potential predictors were obtained and Cox regression performed on time to hospital encounter 1-year after the baseline visit. RESULTS: Thirty-five out of 605 (5.8%) PD patients (62.5±8.9 years old; 59.8% males) presented an AH during the 1-year follow-up after the baseline visit. Traumatic falls represented the most frequent cause of admission, being 23.7% of all acute hospitalizations. To suffer from motor fluctuations (HR [hazard ratio] 2.461; 95% CI, 1.065-5.678; p = 0.035), a very severe non-motor symptoms burden (HR [hazard ratio] 2.828; 95% CI, 1.319-6.063; p = 0.008), falls (HR 3.966; 95% CI 1.757-8.470; p = 0.001), and dysphagia (HR 2.356; 95% CI 1.124-4.941; p = 0.023) was associated with AH after adjustment to age, gender, disease duration, levodopa equivalent daily dose, total number of non-antiparkinsonian drugs, and UPDRS-IIIOFF. Of the previous variables, only falls (HR 2.998; 95% CI 1.080-8.322; p = 0.035) was an independent predictor of AH. CONCLUSION: Falls is an independent predictor of AH in PD patients.IOS PRESS2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=7998https://www.scopus.com/inward/record.uri?eid=2-s2.0-85147458316&doi=10.3233%2fJPD-212539&partnerID=40&md5=aab9777234d9f689ad22e24f85dd5381Journal of Parkinsons DiseaseISSN: 18777171ISSNe: 1877718Xreponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p79982026-06-14T12:41:47Z
dc.title.none.fl_str_mv	Falls Predict Acute Hospitalization in Parkinson's Disease.
title	Falls Predict Acute Hospitalization in Parkinson's Disease.
spellingShingle	Falls Predict Acute Hospitalization in Parkinson's Disease. Santos García D levodopa aged complication female human male middle aged Parkinson disease proportional hazards model risk factor Spain Aged Female Humans Levodopa Male Middle Aged Parkinson Disease Proportional Hazards Models Risk Factors Spain
title_short	Falls Predict Acute Hospitalization in Parkinson's Disease.
title_full	Falls Predict Acute Hospitalization in Parkinson's Disease.
title_fullStr	Falls Predict Acute Hospitalization in Parkinson's Disease.
title_full_unstemmed	Falls Predict Acute Hospitalization in Parkinson's Disease.
title_sort	Falls Predict Acute Hospitalization in Parkinson's Disease.
dc.creator.none.fl_str_mv	Santos García D de Deus Fonticoba T Cores C Castro ES Hernández Vara J Jesús S Mir P Cosgaya M Martí MJ Pastor P Cabo I Seijo M Legarda I Vives B Caballol N Rúiz Martínez J Croitoru I Cubo E Miranda J Alonso Losada MG Labandeira C López Ariztegui N Morales-Casado M González Aramburu I Infante J Escalante S Bernardo N Blázquez Estrada M Menéndez González M Caldentey JG Borrué C Vela L Catalán MJ Gómez Mayordomo V Kurtis M Prieto C Ordás C Nogueira V López Manzanares L Ávila Rivera MA Puente V García Moreno JM Solano Vila B Álvarez Sauco M Carrillo Padilla F Carlos Martínez Castrillo J Sánchez Alonso P Gastón I Kulisevsky J Valero C de Fábregues O González Ardura J López Díaz LM Martinez-Martin P
author	Santos García D
author_facet	Santos García D de Deus Fonticoba T Cores C Castro ES Hernández Vara J Jesús S Mir P Cosgaya M Martí MJ Pastor P Cabo I Seijo M Legarda I Vives B Caballol N Rúiz Martínez J Croitoru I Cubo E Miranda J Alonso Losada MG Labandeira C López Ariztegui N Morales-Casado M González Aramburu I Infante J Escalante S Bernardo N Blázquez Estrada M Menéndez González M Caldentey JG Borrué C Vela L Catalán MJ Gómez Mayordomo V Kurtis M Prieto C Ordás C Nogueira V López Manzanares L Ávila Rivera MA Puente V García Moreno JM Solano Vila B Álvarez Sauco M Carrillo Padilla F Carlos Martínez Castrillo J Sánchez Alonso P Gastón I Kulisevsky J Valero C de Fábregues O González Ardura J López Díaz LM Martinez-Martin P
author_role	author
author2	de Deus Fonticoba T Cores C Castro ES Hernández Vara J Jesús S Mir P Cosgaya M Martí MJ Pastor P Cabo I Seijo M Legarda I Vives B Caballol N Rúiz Martínez J Croitoru I Cubo E Miranda J Alonso Losada MG Labandeira C López Ariztegui N Morales-Casado M González Aramburu I Infante J Escalante S Bernardo N Blázquez Estrada M Menéndez González M Caldentey JG Borrué C Vela L Catalán MJ Gómez Mayordomo V Kurtis M Prieto C Ordás C Nogueira V López Manzanares L Ávila Rivera MA Puente V García Moreno JM Solano Vila B Álvarez Sauco M Carrillo Padilla F Carlos Martínez Castrillo J Sánchez Alonso P Gastón I Kulisevsky J Valero C de Fábregues O González Ardura J López Díaz LM Martinez-Martin P
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	levodopa aged complication female human male middle aged Parkinson disease proportional hazards model risk factor Spain Aged Female Humans Levodopa Male Middle Aged Parkinson Disease Proportional Hazards Models Risk Factors Spain
topic	levodopa aged complication female human male middle aged Parkinson disease proportional hazards model risk factor Spain Aged Female Humans Levodopa Male Middle Aged Parkinson Disease Proportional Hazards Models Risk Factors Spain
description	BACKGROUND: There is a need for identifying risk factors for hospitalization in Parkinson's disease (PD) and also interventions to reduce acute hospital admission. OBJECTIVE: To analyze the frequency, causes, and predictors of acute hospitalization (AH) in PD patients from a Spanish cohort. METHODS: PD patients recruited from 35 centers of Spain from the COPPADIS-2015 (COhort of Patients with PArkinson's DIsease in Spain, 2015) cohort from January 2016 to November 2017, were included in the study. In order to identify predictors of AH, Kaplan-Meier estimates of factors considered as potential predictors were obtained and Cox regression performed on time to hospital encounter 1-year after the baseline visit. RESULTS: Thirty-five out of 605 (5.8%) PD patients (62.5±8.9 years old; 59.8% males) presented an AH during the 1-year follow-up after the baseline visit. Traumatic falls represented the most frequent cause of admission, being 23.7% of all acute hospitalizations. To suffer from motor fluctuations (HR [hazard ratio] 2.461; 95% CI, 1.065-5.678; p = 0.035), a very severe non-motor symptoms burden (HR [hazard ratio] 2.828; 95% CI, 1.319-6.063; p = 0.008), falls (HR 3.966; 95% CI 1.757-8.470; p = 0.001), and dysphagia (HR 2.356; 95% CI 1.124-4.941; p = 0.023) was associated with AH after adjustment to age, gender, disease duration, levodopa equivalent daily dose, total number of non-antiparkinsonian drugs, and UPDRS-IIIOFF. Of the previous variables, only falls (HR 2.998; 95% CI 1.080-8.322; p = 0.035) was an independent predictor of AH. CONCLUSION: Falls is an independent predictor of AH in PD patients.
publishDate	2023
dc.date.none.fl_str_mv	2023
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=7998 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85147458316&doi=10.3233%2fJPD-212539&partnerID=40&md5=aab9777234d9f689ad22e24f85dd5381
url	https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=7998 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85147458316&doi=10.3233%2fJPD-212539&partnerID=40&md5=aab9777234d9f689ad22e24f85dd5381
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	IOS PRESS
publisher.none.fl_str_mv	IOS PRESS
dc.source.none.fl_str_mv	Journal of Parkinsons Disease ISSN: 18777171 ISSNe: 1877718X reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str	Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str	r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection	r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_	1869425050185105408
score	15,81155

Falls Predict Acute Hospitalization in Parkinson's Disease.

Similares en LA Referencia