High frequency of antimicrobial drug resistance of diarrheagenic Escherichia coli in infants in Peru

In a prospective passive diarrhea surveillance cohort study of 1,034 infants of low socioeconomic communi- ties in Lima, Peru, we determined the prevalence and antimicrobial drug susceptibility of the diarrheagenic Escherichia coli. The prevalence of diarrheagenic E. coli was 29% (161 of 557) in chi...

Descripción completa

Detalles Bibliográficos
Autores: Ochoa, Theresa J., Ruiz Blazquez, Joaquim, Molina, Margarita, Valle Mendoza, Luis Javier del|||0000-0001-9916-1741, Vargas Orihuela, Martha, Gil, Ana I., Ecker, Lucie, Barletta, Francesca, Hall, Eric, Clearcy, Thomas, Lanata, Claudio F.
Tipo de recurso: artículo
Fecha de publicación:2009
País:España
Institución:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:upcommons.upc.edu:2117/403041
Acceso en línea:https://hdl.handle.net/2117/403041
Access Level:acceso abierto
Palabra clave:Diarrhea in children
Pediatric gastroenterology
Diarrhea
Escherichia coli
Antimicrobial drug
Diarrea en els infants
Gastroenterologia pediàtrica
Àrees temàtiques de la UPC::Ciències de la salut
Descripción
Sumario:In a prospective passive diarrhea surveillance cohort study of 1,034 infants of low socioeconomic communi- ties in Lima, Peru, we determined the prevalence and antimicrobial drug susceptibility of the diarrheagenic Escherichia coli. The prevalence of diarrheagenic E. coli was 29% (161 of 557) in children with gastroenteritis and 30% (58 of 195) in the control group without diarrhea. The most common E. coli pathogens in diarrhea were enteroaggregative E. coli (EAEC) (14%), enteropathogenic E. coli (EPEC) (7%), diffusely adherent E. coli (DAEC) (4%), and enterotoxigenic E. coli (ETEC) (4%). Diarrheagenic E. coli as a group exhibited high levels of antimicrobial drug resistance in diarrheal cases to ampicillin (85%), cotrimoxazole (79%), tetracycline (65%), and nalidixic acid (28%). Among individual E. coli groups in patients with diarrhea, DAEC and EAEC exhibited significant higher frequencies of resistance to ampicillin, cotrimoxazole, tetracycline and nalidixic acid than EPEC and ETEC. Antimicrobial drug resistance to ampicillin and cot- rimoxazole were more frequent in E. coli isolated from diarrheal samples than controls, which reflected greater antibiotic exposure in patients with gastroenteritis.

Similares en LA Referencia