Influence of nonalcoholic fatty liver disease severity on carotid adventitial vasa vasorum

Introduction: Nonalcoholic fatty liver disease (NAFLD) affects a quarter of the world’s population and encompasses a spectrum of liver conditions, from non-alcoholic steatohepatitis (NASH) to inflammation and fibrosis. In addition, NAFLD also links to extrahepatic conditions like diabetes or obesity...

ver descrição completa

Detalhes bibliográficos
Autores: León-Mengíbar, Josep, Sánchez Peña, Enric, Herrerías-González, Fernando, de la Fuente, Maricruz, Santamaría, Maite, Valdivielso Revilla, José Manuel, Bermúdez López, Marcelino, Castro, Eva, Pallares, Judit, Matias-Guiu, Xavier, Vilardell, Felip, Caixàs, Assumpta, Bueno, Marta, Martí, Raquel, Lecube Torelló, Albert
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2024
País:España
Recursos:Universitat de Lleida (UdL)
Repositório:Repositori Obert UdL
OAI Identifier:oai:repositori.udl.cat:10459.1/466207
Acesso em linha:https://doi.org/10.3389/fendo.2024.1366015
https://hdl.handle.net/10459.1/466207
Access Level:Acceso aberto
Palavra-chave:Atherosclerosis
Nonalcoholic fatty liver disease
Obesity
Vasa vasorum
Vascular disease
id ES_f8ca5aa60ab58f6f900c70dcf8ea10f7
oai_identifier_str oai:repositori.udl.cat:10459.1/466207
network_acronym_str ES
network_name_str España
repository_id_str
spelling Influence of nonalcoholic fatty liver disease severity on carotid adventitial vasa vasorumLeón-Mengíbar, JosepSánchez Peña, EnricHerrerías-González, Fernando de la Fuente, MaricruzSantamaría, MaiteValdivielso Revilla, José ManuelBermúdez López, MarcelinoCastro, EvaPallares, JuditMatias-Guiu, XavierVilardell, FelipCaixàs, AssumptaBueno, MartaMartí, RaquelLecube Torelló, AlbertAtherosclerosisNonalcoholic fatty liver diseaseObesityVasa vasorumVascular diseaseIntroduction: Nonalcoholic fatty liver disease (NAFLD) affects a quarter of the world’s population and encompasses a spectrum of liver conditions, from non-alcoholic steatohepatitis (NASH) to inflammation and fibrosis. In addition, NAFLD also links to extrahepatic conditions like diabetes or obesity. However, it remains unclear if NAFLD independently correlates with the onset and progression of atherosclerosis. Material and methods: This cross-sectional study aimed to explore the relationship between NAFLD severity, assessed via liver biopsy, and early atherosclerosis using adventitial vasa vasorum (VV) density. It included 44 patients with obesity (33 with steatosis, 11 with NASH) undergoing bariatric surgery. Results: Results revealed no significant differences in adventitial VV density between steatosis and NASH groups, neither in the mean values [0.759 ± 0.104 vs. 0.780 ± 0.043, P=0.702] nor left-right sides. Similarly, carotid intima-media thickness (cIMT) did not vary between these groups. Additionally, no linear correlation existed between VV density and cIMT. Only gender showed an association with VV density. Conclusion: These findings suggest that NASH severity doesn’t independently drive early atherosclerosis or affects cIMT. Gender might play a role in early atherosclerotic disease in NAFLD, impacting VV density and cIMT. This highlights the need to consider other risk factors when evaluating cardiovascular risk in NAFLD patients.The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was supported by grants from the Fundación Sociedad Española Endocrinología y Nutrición (FSEEN) and Laboratorios Almirall (“Beca FSEEN de ayuda a la investigación sobre factores de riesgo cardiovascular”).Frontiers2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://doi.org/10.3389/fendo.2024.1366015https://hdl.handle.net/10459.1/466207reponame:Repositori Obert UdL instname:Universitat de Lleida (UdL)InglésReproducció del document publicat a: https://doi.org/10.3389/fendo.2024.1366015Frontiers in Endocrinology, 2024, vol. 15, art. núm. 1366015cc-by (c) León-Mengibar et al., 2024Attribution 4.0 Internationalinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/oai:repositori.udl.cat:10459.1/4662072026-06-24T12:42:17Z
dc.title.none.fl_str_mv Influence of nonalcoholic fatty liver disease severity on carotid adventitial vasa vasorum
title Influence of nonalcoholic fatty liver disease severity on carotid adventitial vasa vasorum
spellingShingle Influence of nonalcoholic fatty liver disease severity on carotid adventitial vasa vasorum
León-Mengíbar, Josep
Atherosclerosis
Nonalcoholic fatty liver disease
Obesity
Vasa vasorum
Vascular disease
title_short Influence of nonalcoholic fatty liver disease severity on carotid adventitial vasa vasorum
title_full Influence of nonalcoholic fatty liver disease severity on carotid adventitial vasa vasorum
title_fullStr Influence of nonalcoholic fatty liver disease severity on carotid adventitial vasa vasorum
title_full_unstemmed Influence of nonalcoholic fatty liver disease severity on carotid adventitial vasa vasorum
title_sort Influence of nonalcoholic fatty liver disease severity on carotid adventitial vasa vasorum
dc.creator.none.fl_str_mv León-Mengíbar, Josep
Sánchez Peña, Enric
Herrerías-González, Fernando
de la Fuente, Maricruz
Santamaría, Maite
Valdivielso Revilla, José Manuel
Bermúdez López, Marcelino
Castro, Eva
Pallares, Judit
Matias-Guiu, Xavier
Vilardell, Felip
Caixàs, Assumpta
Bueno, Marta
Martí, Raquel
Lecube Torelló, Albert
author León-Mengíbar, Josep
author_facet León-Mengíbar, Josep
Sánchez Peña, Enric
Herrerías-González, Fernando
de la Fuente, Maricruz
Santamaría, Maite
Valdivielso Revilla, José Manuel
Bermúdez López, Marcelino
Castro, Eva
Pallares, Judit
Matias-Guiu, Xavier
Vilardell, Felip
Caixàs, Assumpta
Bueno, Marta
Martí, Raquel
Lecube Torelló, Albert
author_role author
author2 Sánchez Peña, Enric
Herrerías-González, Fernando
de la Fuente, Maricruz
Santamaría, Maite
Valdivielso Revilla, José Manuel
Bermúdez López, Marcelino
Castro, Eva
Pallares, Judit
Matias-Guiu, Xavier
Vilardell, Felip
Caixàs, Assumpta
Bueno, Marta
Martí, Raquel
Lecube Torelló, Albert
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Atherosclerosis
Nonalcoholic fatty liver disease
Obesity
Vasa vasorum
Vascular disease
topic Atherosclerosis
Nonalcoholic fatty liver disease
Obesity
Vasa vasorum
Vascular disease
description Introduction: Nonalcoholic fatty liver disease (NAFLD) affects a quarter of the world’s population and encompasses a spectrum of liver conditions, from non-alcoholic steatohepatitis (NASH) to inflammation and fibrosis. In addition, NAFLD also links to extrahepatic conditions like diabetes or obesity. However, it remains unclear if NAFLD independently correlates with the onset and progression of atherosclerosis. Material and methods: This cross-sectional study aimed to explore the relationship between NAFLD severity, assessed via liver biopsy, and early atherosclerosis using adventitial vasa vasorum (VV) density. It included 44 patients with obesity (33 with steatosis, 11 with NASH) undergoing bariatric surgery. Results: Results revealed no significant differences in adventitial VV density between steatosis and NASH groups, neither in the mean values [0.759 ± 0.104 vs. 0.780 ± 0.043, P=0.702] nor left-right sides. Similarly, carotid intima-media thickness (cIMT) did not vary between these groups. Additionally, no linear correlation existed between VV density and cIMT. Only gender showed an association with VV density. Conclusion: These findings suggest that NASH severity doesn’t independently drive early atherosclerosis or affects cIMT. Gender might play a role in early atherosclerotic disease in NAFLD, impacting VV density and cIMT. This highlights the need to consider other risk factors when evaluating cardiovascular risk in NAFLD patients.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.3389/fendo.2024.1366015
https://hdl.handle.net/10459.1/466207
url https://doi.org/10.3389/fendo.2024.1366015
https://hdl.handle.net/10459.1/466207
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3389/fendo.2024.1366015
Frontiers in Endocrinology, 2024, vol. 15, art. núm. 1366015
dc.rights.none.fl_str_mv cc-by (c) León-Mengibar et al., 2024
Attribution 4.0 International
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
rights_invalid_str_mv cc-by (c) León-Mengibar et al., 2024
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:Repositori Obert UdL
instname:Universitat de Lleida (UdL)
instname_str Universitat de Lleida (UdL)
reponame_str Repositori Obert UdL
collection Repositori Obert UdL
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869425034624237568
score 15.812429

Registros relacionados