Dopamine neuron activity encodes the length of upcoming contralateral movement sequences

Highlights • Developed a freely moving task where mice learn individual forelimb sequences • Movement-modulated DANs encode the length of contralateral movement sequences • The activity of reward-modulated DANs is not lateralized • Dopamine depletion impaired contralateral, but not ipsilateral, sequ...

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Authors: Mendonça, Marcelo, Alves da Silva, Joaquim, Hernández, Ledia F., Castela, Iván, Obeso, José, Costa, Rui M.
Format: article
Publication Date:2024
Country:España
Institution:Universidad Camilo José Cela (UCJC)
Repository:Depósito Digital e-UCJC
OAI Identifier:oai:repositorio.ucjc.edu:20.500.12020/1539
Online Access:https://linkinghub.elsevier.com/retrieve/pii/S0960-9822(24)00104-0
http://hdl.handle.net/20.500.12020/1539
https://doi.org/10.1016/j.cub.2024.01.067
Access Level:Open access
Keyword:Ciencias Biomédicas
Parkinson’s Disease
Dopamine
Substantia Nigra Pars Compacta
Movement
32 Ciencias Médicas
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oai_identifier_str oai:repositorio.ucjc.edu:20.500.12020/1539
network_acronym_str ES
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spelling Dopamine neuron activity encodes the length of upcoming contralateral movement sequencesMendonça, MarceloAlves da Silva, JoaquimHernández, Ledia F.Castela, IvánObeso, JoséCosta, Rui M.Ciencias BiomédicasParkinson’s DiseaseDopamineSubstantia Nigra Pars CompactaMovement32 Ciencias MédicasHighlights • Developed a freely moving task where mice learn individual forelimb sequences • Movement-modulated DANs encode the length of contralateral movement sequences • The activity of reward-modulated DANs is not lateralized • Dopamine depletion impaired contralateral, but not ipsilateral, sequence length Summary Dopaminergic neurons (DANs) in the substantia nigra pars compacta (SNc) have been related to movement speed, and loss of these neurons leads to bradykinesia in Parkinson’s disease (PD). However, other aspects of movement vigor are also affected in PD; for example, movement sequences are typically shorter. However, the relationship between the activity of DANs and the length of movement sequences is unknown. We imaged activity of SNc DANs in mice trained in a freely moving operant task, which relies on individual forelimb sequences. We uncovered a similar proportion of SNc DANs increasing their activity before either ipsilateral or contralateral sequences. However, the magnitude of this activity was higher for contralateral actions and was related to contralateral but not ipsilateral sequence length. In contrast, the activity of reward-modulated DANs, largely distinct from those modulated by movement, was not lateralized. Finally, unilateral dopamine depletion impaired contralateral, but not ipsilateral, sequence length. These results indicate that movement-initiation DANs encode more than a general motivation signal and invigorate aspects of contralateral movements.Cell Press2024info:eu-repo/semantics/articlehttps://linkinghub.elsevier.com/retrieve/pii/S0960-9822(24)00104-0http://hdl.handle.net/20.500.12020/1539https://doi.org/10.1016/j.cub.2024.01.067reponame:Depósito Digital e-UCJCinstname:Universidad Camilo José Cela (UCJC)Inglésinfo:eu-repo/semantics/openAccessoai:repositorio.ucjc.edu:20.500.12020/15392026-05-27T07:36:51Z
dc.title.none.fl_str_mv Dopamine neuron activity encodes the length of upcoming contralateral movement sequences
title Dopamine neuron activity encodes the length of upcoming contralateral movement sequences
spellingShingle Dopamine neuron activity encodes the length of upcoming contralateral movement sequences
Mendonça, Marcelo
Ciencias Biomédicas
Parkinson’s Disease
Dopamine
Substantia Nigra Pars Compacta
Movement
32 Ciencias Médicas
title_short Dopamine neuron activity encodes the length of upcoming contralateral movement sequences
title_full Dopamine neuron activity encodes the length of upcoming contralateral movement sequences
title_fullStr Dopamine neuron activity encodes the length of upcoming contralateral movement sequences
title_full_unstemmed Dopamine neuron activity encodes the length of upcoming contralateral movement sequences
title_sort Dopamine neuron activity encodes the length of upcoming contralateral movement sequences
dc.creator.none.fl_str_mv Mendonça, Marcelo
Alves da Silva, Joaquim
Hernández, Ledia F.
Castela, Iván
Obeso, José
Costa, Rui M.
author Mendonça, Marcelo
author_facet Mendonça, Marcelo
Alves da Silva, Joaquim
Hernández, Ledia F.
Castela, Iván
Obeso, José
Costa, Rui M.
author_role author
author2 Alves da Silva, Joaquim
Hernández, Ledia F.
Castela, Iván
Obeso, José
Costa, Rui M.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Ciencias Biomédicas
Parkinson’s Disease
Dopamine
Substantia Nigra Pars Compacta
Movement
32 Ciencias Médicas
topic Ciencias Biomédicas
Parkinson’s Disease
Dopamine
Substantia Nigra Pars Compacta
Movement
32 Ciencias Médicas
description Highlights • Developed a freely moving task where mice learn individual forelimb sequences • Movement-modulated DANs encode the length of contralateral movement sequences • The activity of reward-modulated DANs is not lateralized • Dopamine depletion impaired contralateral, but not ipsilateral, sequence length Summary Dopaminergic neurons (DANs) in the substantia nigra pars compacta (SNc) have been related to movement speed, and loss of these neurons leads to bradykinesia in Parkinson’s disease (PD). However, other aspects of movement vigor are also affected in PD; for example, movement sequences are typically shorter. However, the relationship between the activity of DANs and the length of movement sequences is unknown. We imaged activity of SNc DANs in mice trained in a freely moving operant task, which relies on individual forelimb sequences. We uncovered a similar proportion of SNc DANs increasing their activity before either ipsilateral or contralateral sequences. However, the magnitude of this activity was higher for contralateral actions and was related to contralateral but not ipsilateral sequence length. In contrast, the activity of reward-modulated DANs, largely distinct from those modulated by movement, was not lateralized. Finally, unilateral dopamine depletion impaired contralateral, but not ipsilateral, sequence length. These results indicate that movement-initiation DANs encode more than a general motivation signal and invigorate aspects of contralateral movements.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://linkinghub.elsevier.com/retrieve/pii/S0960-9822(24)00104-0
http://hdl.handle.net/20.500.12020/1539
https://doi.org/10.1016/j.cub.2024.01.067
url https://linkinghub.elsevier.com/retrieve/pii/S0960-9822(24)00104-0
http://hdl.handle.net/20.500.12020/1539
https://doi.org/10.1016/j.cub.2024.01.067
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Cell Press
publisher.none.fl_str_mv Cell Press
dc.source.none.fl_str_mv reponame:Depósito Digital e-UCJC
instname:Universidad Camilo José Cela (UCJC)
instname_str Universidad Camilo José Cela (UCJC)
reponame_str Depósito Digital e-UCJC
collection Depósito Digital e-UCJC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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