E93-depleted adult insects preserve the prothoracic gland and molt again

Insect metamorphosis originated around the middle Devonian, associated with the innovation of the final molt; this occurs after histolysis of the prothoracic gland (PG; which produces the molting hormone) in the first days of adulthood. We previously hypothesized that transcription factor E93 is cru...

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Detalles Bibliográficos
Autores: Kamsoi, Orathai, Bellés, Xavier
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/236274
Acceso en línea:http://hdl.handle.net/10261/236274
Access Level:acceso abierto
Palabra clave:Prothoracic gland
E93FTZ-F1
EcdysoneInsect metamorphosis
MEKRE93 pathway
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spelling E93-depleted adult insects preserve the prothoracic gland and molt againKamsoi, OrathaiBellés, XavierProthoracic glandE93FTZ-F1EcdysoneInsect metamorphosisMEKRE93 pathwayInsect metamorphosis originated around the middle Devonian, associated with the innovation of the final molt; this occurs after histolysis of the prothoracic gland (PG; which produces the molting hormone) in the first days of adulthood. We previously hypothesized that transcription factor E93 is crucial in the emergence of metamorphosis, because it triggers metamorphosis in extant insects. This work on the cockroach Blattella germanica reveals that E93 also plays a crucial role in the histolysis of PG, which fits the above hypothesis. Previous studies have shown that the transcription factor FTZ-F1 is essential for PG histolysis. We have found that FTZ-F1 depletion towards the end of the final nymphal instar downregulates the expression of E93, whereas E93-depleted nymphs molt to adults that retain a functional PG. Interestingly, these adults are able to molt again, which is exceptional in insects. The study of insects able to molt again in the adult stage may reveal clues about how nymphal epidermal cells definitively become adult cells, and whether it is possible to reverse this process.O.K. received a Royal Thai Government Scholarship to carry out a PhD thesis in X.B.’s laboratory in Barcelona. This work was supported by the Ministerio de Economia y Competitividad (CGL2012–36251, CGL2015–64727-P and PID2019-104483GB-I00 to X.B.), the Consejo Superior de Investigaciones Científicas (2019AEP029), the Generalitat de Catalunya (2017 SGR 1030 to X.B.) and the European Regional Development Fund.Company of BiologistsRoyal Thai GovernmentMinisterio de Economía y Competitividad (España)Ministerio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)Consejo Superior de Investigaciones Científicas (España)Generalitat de CatalunyaEuropean CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2021202120202021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/236274reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CGL2015–64727-Pinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-104483GB-I00PID2019-104483GB-I00/AEI/10.13039/501100011033http://dx.doi.org/10.1242/dev.190066Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2362742026-05-22T06:33:51Z
dc.title.none.fl_str_mv E93-depleted adult insects preserve the prothoracic gland and molt again
title E93-depleted adult insects preserve the prothoracic gland and molt again
spellingShingle E93-depleted adult insects preserve the prothoracic gland and molt again
Kamsoi, Orathai
Prothoracic gland
E93FTZ-F1
EcdysoneInsect metamorphosis
MEKRE93 pathway
title_short E93-depleted adult insects preserve the prothoracic gland and molt again
title_full E93-depleted adult insects preserve the prothoracic gland and molt again
title_fullStr E93-depleted adult insects preserve the prothoracic gland and molt again
title_full_unstemmed E93-depleted adult insects preserve the prothoracic gland and molt again
title_sort E93-depleted adult insects preserve the prothoracic gland and molt again
dc.creator.none.fl_str_mv Kamsoi, Orathai
Bellés, Xavier
author Kamsoi, Orathai
author_facet Kamsoi, Orathai
Bellés, Xavier
author_role author
author2 Bellés, Xavier
author2_role author
dc.contributor.none.fl_str_mv Royal Thai Government
Ministerio de Economía y Competitividad (España)
Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
Consejo Superior de Investigaciones Científicas (España)
Generalitat de Catalunya
European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Prothoracic gland
E93FTZ-F1
EcdysoneInsect metamorphosis
MEKRE93 pathway
topic Prothoracic gland
E93FTZ-F1
EcdysoneInsect metamorphosis
MEKRE93 pathway
description Insect metamorphosis originated around the middle Devonian, associated with the innovation of the final molt; this occurs after histolysis of the prothoracic gland (PG; which produces the molting hormone) in the first days of adulthood. We previously hypothesized that transcription factor E93 is crucial in the emergence of metamorphosis, because it triggers metamorphosis in extant insects. This work on the cockroach Blattella germanica reveals that E93 also plays a crucial role in the histolysis of PG, which fits the above hypothesis. Previous studies have shown that the transcription factor FTZ-F1 is essential for PG histolysis. We have found that FTZ-F1 depletion towards the end of the final nymphal instar downregulates the expression of E93, whereas E93-depleted nymphs molt to adults that retain a functional PG. Interestingly, these adults are able to molt again, which is exceptional in insects. The study of insects able to molt again in the adult stage may reveal clues about how nymphal epidermal cells definitively become adult cells, and whether it is possible to reverse this process.
publishDate 2020
dc.date.none.fl_str_mv 2020
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/236274
url http://hdl.handle.net/10261/236274
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CGL2015–64727-P
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-104483GB-I00
PID2019-104483GB-I00/AEI/10.13039/501100011033
http://dx.doi.org/10.1242/dev.190066
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Company of Biologists
publisher.none.fl_str_mv Company of Biologists
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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