Frequency of sensitization to the individual fragrances of fragrance mix I and II according to the factors included in the MOAHLFA index

Background Fragrances constitute the second most frequent cause of allergic contact dermatitis in Spain. Objectives To determine the rate of sensitization to the individual fragrances of fragrance mix (FM) I and FM II for each of the demographic and clinical factors included in the MOAHLFA (male, oc...

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Detalles Bibliográficos
Autores: Sanchez-Pujol, MJ, Docampo-Simon, A, Mercader, P, Gonzalez-Perez, R, Hervella-Garces, M, Sanz-Sanchez, T, Cordoba, S, Sanchez-Perez, J, Heras-Mendaza, F, Gimenez-Arnau, AM, Gatica-Ortega, ME, Pastor-Nieto, MA, Zaragoza, V, Carrascosa, JM, Garcia-Bravo, B, Ruiz-Gonzalez, I, Borrego, L, Sanchez-Pedreno, P, Frutos, JO, Armario-Hita, JC, Garcia-Gavin, J, Fernandez-Redondo, V, Serra, E, Silvestre, JF
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p4977
Acceso en línea:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4977
http://hdl.handle.net/10230/47244
Access Level:acceso abierto
Palabra clave:allergic contact dermatitis
epidemiology
fragrances
MOAHLFA index
patch test
Descripción
Sumario:Background Fragrances constitute the second most frequent cause of allergic contact dermatitis in Spain. Objectives To determine the rate of sensitization to the individual fragrances of fragrance mix (FM) I and FM II for each of the demographic and clinical factors included in the MOAHLFA (male, occupational dermatitis, atopic dermatitis, hand dermatitis, leg dermatitis, facial dermatitis, age) index. Methods We conducted a 5-year retrospective study in 23 Spanish centres. We identified the patients who had undergone patch testing with a specific fragrance series after reacting positively to fragrance markers in a baseline series. We obtained the MOAHLFA index items in this population, then calculated for each demographic and clinical factor the frequencies of sensitization to the individual fragrances of FM I and FM II. Results A specific fragrance series was patch tested in 1013 patients. The most frequent allergens in men, women, children, and retired people were Evernia prunastri (16%), geraniol (16.6%), isoeugenol (17.9%), and geraniol (22.4%), respectively. Citral (20.5%) and Lyral (14.5%) were the most common allergens in occupational eczemas and were also associated with a large proportion of hand and facial dermatitis. Conclusions Frequency of sensitization to the individual fragrances of FM I and FM II varies with age, sex, affected body region, and history of occupational or atopic dermatitis.

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