Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue

González Franquesa, Alba; Gama-Perez, Pau; Kulis, Marta; Szczepanowska, K.; Dahdah, Norma; Moreno-Gomez, Sonia; Latorre Pellicer, Ana; Fernández Ruiz, Rebeca; Aguilar-Mogas, Antoni; Hoffman, Anne; Monelli, Erika; Samino Gené, Sara; Miró-Blanch, Joan; Oemer, Gregor; Duran, Xavier; Sanchez-Rebordelo, Estrella; Schneeberger, Marc; Obach, Merce; Montane, Joel; Castellano, Giancarlo; Chapaprieta, Vicente; Sun, Wenfei; Navarro, Lourdes; Prieto, Ignacio; Castaño, Carlos; Novials, Anna; Gomis, Ramon, 1946-; Monsalve, Maria; Claret i Carles, Marc; Graupera i Garcia-Milà, Mariona; Soria, Guadalupe; Wolfrum, Christian; Vendrell, Joan; Fernández-Veledo, Sonia; Enriquez, Jose Antonio; Carracedo Álvarez, Ángel; Perales Losa, Carlos; Nogueiras, Rubén; Herrero, Laura; Trifunovic, Aleksandra; Keller, Markus A; Yanes, Oscar; Sales-Pardo, Marta; Guimerà, Roger; Blüher, Matthias; Martín-Subero, José Ignacio; Garcia Roves, Pablo M.

Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue

Metabolic plasticity is the ability of a biological system to adapt its metabolic phenotype to different environmental stressors. We used a whole-body and tissue-specific phenotypic, functional, proteomic, metabolomic and transcriptomic approach to systematically assess metabolic plasticity in diet-...

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Autores:	González Franquesa, Alba, Gama-Perez, Pau, Kulis, Marta, Szczepanowska, K., Dahdah, Norma, Moreno-Gomez, Sonia, Latorre Pellicer, Ana, Fernández Ruiz, Rebeca, Aguilar-Mogas, Antoni, Hoffman, Anne, Monelli, Erika, Samino Gené, Sara, Miró-Blanch, Joan, Oemer, Gregor, Duran, Xavier, Sanchez-Rebordelo, Estrella, Schneeberger, Marc, Obach, Merce, Montane, Joel, Castellano, Giancarlo, Chapaprieta, Vicente, Sun, Wenfei, Navarro, Lourdes, Prieto, Ignacio, Castaño, Carlos, Novials, Anna, Gomis, Ramon, 1946-, Monsalve, Maria, Claret i Carles, Marc, Graupera i Garcia-Milà, Mariona, Soria, Guadalupe, Wolfrum, Christian, Vendrell, Joan, Fernández-Veledo, Sonia, Enriquez, Jose Antonio, Carracedo Álvarez, Ángel, Perales Losa, Carlos, Nogueiras, Rubén, Herrero, Laura, Trifunovic, Aleksandra, Keller, Markus A, Yanes, Oscar, Sales-Pardo, Marta, Guimerà, Roger, Blüher, Matthias, Martín-Subero, José Ignacio, Garcia Roves, Pablo M.
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2022
País:	España
Institución:	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:	Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:	oai:recercat.cat:2445/190251
Acceso en línea:	https://hdl.handle.net/2445/190251
Access Level:	acceso abierto
Palabra clave:	Resistència a la insulina Obesitat Teixit adipós Mitocondris Insulin resistance Obesity Adipose tissues Mitochondria

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spelling	Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissueGonzález Franquesa, AlbaGama-Perez, PauKulis, MartaSzczepanowska, K.Dahdah, NormaMoreno-Gomez, SoniaLatorre Pellicer, AnaFernández Ruiz, RebecaAguilar-Mogas, AntoniHoffman, AnneMonelli, ErikaSamino Gené, SaraMiró-Blanch, JoanOemer, GregorDuran, XavierSanchez-Rebordelo, EstrellaSchneeberger, MarcObach, MerceMontane, JoelCastellano, GiancarloChapaprieta, VicenteSun, WenfeiNavarro, LourdesPrieto, IgnacioCastaño, CarlosNovials, AnnaGomis, Ramon, 1946-Monsalve, MariaClaret i Carles, MarcGraupera i Garcia-Milà, MarionaSoria, GuadalupeWolfrum, ChristianVendrell, JoanFernández-Veledo, SoniaEnriquez, Jose AntonioCarracedo Álvarez, ÁngelPerales Losa, CarlosNogueiras, RubénHerrero, LauraTrifunovic, AleksandraKeller, Markus AYanes, OscarSales-Pardo, MartaGuimerà, RogerBlüher, MatthiasMartín-Subero, José IgnacioGarcia Roves, Pablo M.Resistència a la insulinaObesitatTeixit adipósMitocondrisInsulin resistanceObesityAdipose tissuesMitochondriaMetabolic plasticity is the ability of a biological system to adapt its metabolic phenotype to different environmental stressors. We used a whole-body and tissue-specific phenotypic, functional, proteomic, metabolomic and transcriptomic approach to systematically assess metabolic plasticity in diet-induced obese mice after a combined nutritional and exercise intervention. Although most obesity and overnutrition-related pathological features were successfully reverted, we observed a high degree of metabolic dysfunction in visceral white adipose tissue, characterized by abnormal mitochondrial morphology and functionality. Despite two sequential therapeutic interventions and an apparent global healthy phenotype, obesity triggered a cascade of events in visceral adipose tissue progressing from mitochondrial metabolic and proteostatic alterations to widespread cellular stress, which compromises its biosynthetic and recycling capacity. In humans, weight loss after bariatric surgery showed a transcriptional signature in visceral adipose tissue similar to our mouse model of obesity reversion. Overall, our data indicate that obesity prompts a lasting metabolic fingerprint that leads to a progressive breakdown of metabolic plasticity in visceral adipose tissue.Elsevier B.V.2022202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion18 p.application/pdfhttps://hdl.handle.net/2445/190251Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésDocument publicat a: https://doi.org/10.1016/j.redox.2022.102353Redox Biology, 2022, vol. 54https://doi.org/10.1016/j.redox.2022.102353info:eu-repo/grantAgreement/EC/H2020/675610info:eu-repo/grantAgreement/EC/H2020/725004cc-by-nc-nd (c) González Franquesa, Alba et al., 2022https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1902512026-05-29T05:05:01Z
dc.title.none.fl_str_mv	Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue
title	Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue
spellingShingle	Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue González Franquesa, Alba Resistència a la insulina Obesitat Teixit adipós Mitocondris Insulin resistance Obesity Adipose tissues Mitochondria
title_short	Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue
title_full	Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue
title_fullStr	Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue
title_full_unstemmed	Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue
title_sort	Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue
dc.creator.none.fl_str_mv	González Franquesa, Alba Gama-Perez, Pau Kulis, Marta Szczepanowska, K. Dahdah, Norma Moreno-Gomez, Sonia Latorre Pellicer, Ana Fernández Ruiz, Rebeca Aguilar-Mogas, Antoni Hoffman, Anne Monelli, Erika Samino Gené, Sara Miró-Blanch, Joan Oemer, Gregor Duran, Xavier Sanchez-Rebordelo, Estrella Schneeberger, Marc Obach, Merce Montane, Joel Castellano, Giancarlo Chapaprieta, Vicente Sun, Wenfei Navarro, Lourdes Prieto, Ignacio Castaño, Carlos Novials, Anna Gomis, Ramon, 1946- Monsalve, Maria Claret i Carles, Marc Graupera i Garcia-Milà, Mariona Soria, Guadalupe Wolfrum, Christian Vendrell, Joan Fernández-Veledo, Sonia Enriquez, Jose Antonio Carracedo Álvarez, Ángel Perales Losa, Carlos Nogueiras, Rubén Herrero, Laura Trifunovic, Aleksandra Keller, Markus A Yanes, Oscar Sales-Pardo, Marta Guimerà, Roger Blüher, Matthias Martín-Subero, José Ignacio Garcia Roves, Pablo M.
author	González Franquesa, Alba
author_facet	González Franquesa, Alba Gama-Perez, Pau Kulis, Marta Szczepanowska, K. Dahdah, Norma Moreno-Gomez, Sonia Latorre Pellicer, Ana Fernández Ruiz, Rebeca Aguilar-Mogas, Antoni Hoffman, Anne Monelli, Erika Samino Gené, Sara Miró-Blanch, Joan Oemer, Gregor Duran, Xavier Sanchez-Rebordelo, Estrella Schneeberger, Marc Obach, Merce Montane, Joel Castellano, Giancarlo Chapaprieta, Vicente Sun, Wenfei Navarro, Lourdes Prieto, Ignacio Castaño, Carlos Novials, Anna Gomis, Ramon, 1946- Monsalve, Maria Claret i Carles, Marc Graupera i Garcia-Milà, Mariona Soria, Guadalupe Wolfrum, Christian Vendrell, Joan Fernández-Veledo, Sonia Enriquez, Jose Antonio Carracedo Álvarez, Ángel Perales Losa, Carlos Nogueiras, Rubén Herrero, Laura Trifunovic, Aleksandra Keller, Markus A Yanes, Oscar Sales-Pardo, Marta Guimerà, Roger Blüher, Matthias Martín-Subero, José Ignacio Garcia Roves, Pablo M.
author_role	author
author2	Gama-Perez, Pau Kulis, Marta Szczepanowska, K. Dahdah, Norma Moreno-Gomez, Sonia Latorre Pellicer, Ana Fernández Ruiz, Rebeca Aguilar-Mogas, Antoni Hoffman, Anne Monelli, Erika Samino Gené, Sara Miró-Blanch, Joan Oemer, Gregor Duran, Xavier Sanchez-Rebordelo, Estrella Schneeberger, Marc Obach, Merce Montane, Joel Castellano, Giancarlo Chapaprieta, Vicente Sun, Wenfei Navarro, Lourdes Prieto, Ignacio Castaño, Carlos Novials, Anna Gomis, Ramon, 1946- Monsalve, Maria Claret i Carles, Marc Graupera i Garcia-Milà, Mariona Soria, Guadalupe Wolfrum, Christian Vendrell, Joan Fernández-Veledo, Sonia Enriquez, Jose Antonio Carracedo Álvarez, Ángel Perales Losa, Carlos Nogueiras, Rubén Herrero, Laura Trifunovic, Aleksandra Keller, Markus A Yanes, Oscar Sales-Pardo, Marta Guimerà, Roger Blüher, Matthias Martín-Subero, José Ignacio Garcia Roves, Pablo M.
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Resistència a la insulina Obesitat Teixit adipós Mitocondris Insulin resistance Obesity Adipose tissues Mitochondria
topic	Resistència a la insulina Obesitat Teixit adipós Mitocondris Insulin resistance Obesity Adipose tissues Mitochondria
description	Metabolic plasticity is the ability of a biological system to adapt its metabolic phenotype to different environmental stressors. We used a whole-body and tissue-specific phenotypic, functional, proteomic, metabolomic and transcriptomic approach to systematically assess metabolic plasticity in diet-induced obese mice after a combined nutritional and exercise intervention. Although most obesity and overnutrition-related pathological features were successfully reverted, we observed a high degree of metabolic dysfunction in visceral white adipose tissue, characterized by abnormal mitochondrial morphology and functionality. Despite two sequential therapeutic interventions and an apparent global healthy phenotype, obesity triggered a cascade of events in visceral adipose tissue progressing from mitochondrial metabolic and proteostatic alterations to widespread cellular stress, which compromises its biosynthetic and recycling capacity. In humans, weight loss after bariatric surgery showed a transcriptional signature in visceral adipose tissue similar to our mouse model of obesity reversion. Overall, our data indicate that obesity prompts a lasting metabolic fingerprint that leads to a progressive breakdown of metabolic plasticity in visceral adipose tissue.
publishDate	2022
dc.date.none.fl_str_mv	2022 2022 2022 2022
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://hdl.handle.net/2445/190251
url	https://hdl.handle.net/2445/190251
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	Document publicat a: https://doi.org/10.1016/j.redox.2022.102353 Redox Biology, 2022, vol. 54 https://doi.org/10.1016/j.redox.2022.102353 info:eu-repo/grantAgreement/EC/H2020/675610 info:eu-repo/grantAgreement/EC/H2020/725004
dc.rights.none.fl_str_mv	cc-by-nc-nd (c) González Franquesa, Alba et al., 2022 https://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess
rights_invalid_str_mv	cc-by-nc-nd (c) González Franquesa, Alba et al., 2022 https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	18 p. application/pdf
dc.publisher.none.fl_str_mv	Elsevier B.V.
publisher.none.fl_str_mv	Elsevier B.V.
dc.source.none.fl_str_mv	Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str	Recercat. Dipósit de la Recerca de Catalunya
collection	Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue

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