SARS-CoV-2 infection in patients with melanoma: results of the Spanish Melanoma Group registry

Background The Spanish Melanoma Group (GEM) developed a national registry of patients with melanoma infected by SARS-CoV-2 ( "GRAVID ").Methods The main objective was to describe the COVID-19 fatality rate in patients with melanoma throughout the pandemic, as well as to explore the effect...

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Detalles Bibliográficos
Autores: Gonzalez-Cao, M, Puertolas, T, Martinez-Vila, C, Carrera, C, Seral, CM, Rodriguez-Jimenez, P, Sequero, S, Cerezuela-Fuentes, P, Ochoa, RF, Munoz, E, Basa, MA, Martin-Liberal, J, Soria, A, Moreno, JFR, Marquez-Rodas, I, Criado, PL, Manzano, JL, Lopez-Castro, R, De Miguel, PA, Villalobos, L, Algarra, SM, Gonzalez-Barrallo, I, Boada, A, Castano, AG, Puig, S, Crespo, G, Fra, PL, Zamora, CA, Rodriguez, MF, Valles, L, Drozdowskyj, A, Gardeazabal, J, Fernandez-Morales, LA, Rodrigo, A, Cruz, R, Yelamos, O, Rubio, B, Mujica, K, Provencio, M, Berrocal, A
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p15453
Acceso en línea:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=15453
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85144741399&doi=10.1007%2fs12094-022-02985-7&partnerID=40&md5=8e4e7ce78532d8e92161810477c94a8b
Access Level:acceso abierto
Palabra clave:Cancer
COVID-19
Immunotherapy
Melanoma
PD-1
Descripción
Sumario:Background The Spanish Melanoma Group (GEM) developed a national registry of patients with melanoma infected by SARS-CoV-2 ( "GRAVID ").Methods The main objective was to describe the COVID-19 fatality rate in patients with melanoma throughout the pandemic, as well as to explore the effect of melanoma treatment and tumor stage on the risk of COVID-19 complications. These are the final data of the register, including cases from February 2020 to September 2021.Results One hundred-fifty cases were registered. Median age was 68 years (range 6-95), 61 (40%) patients were females, and 63 (42%) patients had stage IV. Thirty-nine (26%) were on treatment with immunotherapy, and 17 (11%) with BRAF-MEK inhibitors. COVID-19 was resolved in 119 cases, including 85 (57%) patients cured, 15 (10%) that died due to melanoma, and 20 (13%) that died due to COVID-19. Only age over 60 years, cardiovascular disorders, and diabetes mellitus increased the risk of death due to COVID-19, but not advanced melanoma stage nor melanoma systemic therapies. Three waves have been covered by the register: February-May 2020, August-November 2020, and December 2020-April 2021. The first wave had the highest number of registered cases and COVID-19 mortality.Conclusion Tumor stage or melanoma treatments are non-significant prognostic factors for COVID-19 mortality. During the pandemic in Spain there was a downward trend in the number of patients registered across the waves, as well as in the severity of the infection.

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