The relationship between depressive symptoms, quality of life and miRNAs 8 years after bariatric surgery

Martínez-Moreno, Jose M.; Mela, Virginia; Agüera, Zaida; Alvarez-Bermudez, Maria D.; Martín-Reyes, Flores; Granero, Roser; Sánchez-García, Ana; Oliva-Olivera, Wilfredo; Tomé, Monica; Moreno-Ruiz, Francisco J.; Soler-Humanes, Rocío; Fernández-Serrano, Jose L.; Sánchez-Gallegos, Pilar; Sancho-Marín, Raquel; Fernández Aranda, Fernando; García-Fuentes, Eduardo; Tinahones, Francisco J.; Garrido-Sánchez, Lourdes

The relationship between depressive symptoms, quality of life and miRNAs 8 years after bariatric surgery

Background: There are conflicting results on whether weight loss after bariatric surgery (BS) might be associated with quality of life (QoL)/depressive symptomatology. We aim to determine whether BS outcomes are associated with QoL/depressive symptomatology in studied patients at the 8-year follow-u...

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Autores:	Martínez-Moreno, Jose M., Mela, Virginia, Agüera, Zaida, Alvarez-Bermudez, Maria D., Martín-Reyes, Flores, Granero, Roser, Sánchez-García, Ana, Oliva-Olivera, Wilfredo, Tomé, Monica, Moreno-Ruiz, Francisco J., Soler-Humanes, Rocío, Fernández-Serrano, Jose L., Sánchez-Gallegos, Pilar, Sancho-Marín, Raquel, Fernández Aranda, Fernando, García-Fuentes, Eduardo, Tinahones, Francisco J., Garrido-Sánchez, Lourdes
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2023
País:	España
Institución:	Universidad de Barcelona
Repositorio:	Dipòsit Digital de la UB
OAI Identifier:	oai:diposit.ub.edu:2445/209237
Acceso en línea:	https://hdl.handle.net/2445/209237
Access Level:	acceso abierto
Palabra clave:	Obesitat Cirurgia de l'obesitat Depressió psíquica Obesity Obesity surgery Mental depression

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spelling	The relationship between depressive symptoms, quality of life and miRNAs 8 years after bariatric surgeryMartínez-Moreno, Jose M.Mela, VirginiaAgüera, ZaidaAlvarez-Bermudez, Maria D.Martín-Reyes, FloresGranero, RoserSánchez-García, AnaOliva-Olivera, WilfredoTomé, MonicaMoreno-Ruiz, Francisco J.Soler-Humanes, RocíoFernández-Serrano, Jose L.Sánchez-Gallegos, PilarSancho-Marín, RaquelFernández Aranda, FernandoGarcía-Fuentes, EduardoTinahones, Francisco J.Garrido-Sánchez, LourdesObesitatCirurgia de l'obesitatDepressió psíquicaObesityObesity surgeryMental depressionBackground: There are conflicting results on whether weight loss after bariatric surgery (BS) might be associated with quality of life (QoL)/depressive symptomatology. We aim to determine whether BS outcomes are associated with QoL/depressive symptomatology in studied patients at the 8-year follow-up after BS, as well as their relationship with different serum proteins and miRNAs. Methods: A total of 53 patients with class III obesity who underwent BS, and then classified into "good responders" and "non-responders" depending on the percentage of excess weight lost (%EWL) 8 years after BS (%EWL ≥ 50% and %EWL < 50%, respectively), were included. Basal serum miRNAs and different proteins were analysed, and patients completed tests to evaluate QoL/depressive symptomatology at 8 years after BS. Results: The good responders group showed higher scores on SF-36 scales of physical functioning, role functioning-physical, role functioning-emotional, body pain and global general health compared with the non-responders. The expression of hsa-miR-101-3p, hsa-miR-15a-5p, hsa-miR-29c-3p, hsa-miR-144-3p and hsa-miR-19b-3p were lower in non-responders. Hsa-miR-19b-3p was the variable associated with the response to BS in a logistic regression model. Conclusions: The mental health of patients after BS is limited by the success of the intervention. In addition, the expression of basal serum miRNAs related to depression/anxiety could predict the success of BS.MDPI2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/209237Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/nu15194109Nutrients, 2023, vol. 15, num.19https://doi.org/10.3390/nu15194109cc-by (c) Mela, V. et al., 2023http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2092372026-05-27T06:46:51Z
dc.title.none.fl_str_mv	The relationship between depressive symptoms, quality of life and miRNAs 8 years after bariatric surgery
title	The relationship between depressive symptoms, quality of life and miRNAs 8 years after bariatric surgery
spellingShingle	The relationship between depressive symptoms, quality of life and miRNAs 8 years after bariatric surgery Martínez-Moreno, Jose M. Obesitat Cirurgia de l'obesitat Depressió psíquica Obesity Obesity surgery Mental depression
title_short	The relationship between depressive symptoms, quality of life and miRNAs 8 years after bariatric surgery
title_full	The relationship between depressive symptoms, quality of life and miRNAs 8 years after bariatric surgery
title_fullStr	The relationship between depressive symptoms, quality of life and miRNAs 8 years after bariatric surgery
title_full_unstemmed	The relationship between depressive symptoms, quality of life and miRNAs 8 years after bariatric surgery
title_sort	The relationship between depressive symptoms, quality of life and miRNAs 8 years after bariatric surgery
dc.creator.none.fl_str_mv	Martínez-Moreno, Jose M. Mela, Virginia Agüera, Zaida Alvarez-Bermudez, Maria D. Martín-Reyes, Flores Granero, Roser Sánchez-García, Ana Oliva-Olivera, Wilfredo Tomé, Monica Moreno-Ruiz, Francisco J. Soler-Humanes, Rocío Fernández-Serrano, Jose L. Sánchez-Gallegos, Pilar Sancho-Marín, Raquel Fernández Aranda, Fernando García-Fuentes, Eduardo Tinahones, Francisco J. Garrido-Sánchez, Lourdes
author	Martínez-Moreno, Jose M.
author_facet	Martínez-Moreno, Jose M. Mela, Virginia Agüera, Zaida Alvarez-Bermudez, Maria D. Martín-Reyes, Flores Granero, Roser Sánchez-García, Ana Oliva-Olivera, Wilfredo Tomé, Monica Moreno-Ruiz, Francisco J. Soler-Humanes, Rocío Fernández-Serrano, Jose L. Sánchez-Gallegos, Pilar Sancho-Marín, Raquel Fernández Aranda, Fernando García-Fuentes, Eduardo Tinahones, Francisco J. Garrido-Sánchez, Lourdes
author_role	author
author2	Mela, Virginia Agüera, Zaida Alvarez-Bermudez, Maria D. Martín-Reyes, Flores Granero, Roser Sánchez-García, Ana Oliva-Olivera, Wilfredo Tomé, Monica Moreno-Ruiz, Francisco J. Soler-Humanes, Rocío Fernández-Serrano, Jose L. Sánchez-Gallegos, Pilar Sancho-Marín, Raquel Fernández Aranda, Fernando García-Fuentes, Eduardo Tinahones, Francisco J. Garrido-Sánchez, Lourdes
author2_role	author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Obesitat Cirurgia de l'obesitat Depressió psíquica Obesity Obesity surgery Mental depression
topic	Obesitat Cirurgia de l'obesitat Depressió psíquica Obesity Obesity surgery Mental depression
description	Background: There are conflicting results on whether weight loss after bariatric surgery (BS) might be associated with quality of life (QoL)/depressive symptomatology. We aim to determine whether BS outcomes are associated with QoL/depressive symptomatology in studied patients at the 8-year follow-up after BS, as well as their relationship with different serum proteins and miRNAs. Methods: A total of 53 patients with class III obesity who underwent BS, and then classified into "good responders" and "non-responders" depending on the percentage of excess weight lost (%EWL) 8 years after BS (%EWL ≥ 50% and %EWL < 50%, respectively), were included. Basal serum miRNAs and different proteins were analysed, and patients completed tests to evaluate QoL/depressive symptomatology at 8 years after BS. Results: The good responders group showed higher scores on SF-36 scales of physical functioning, role functioning-physical, role functioning-emotional, body pain and global general health compared with the non-responders. The expression of hsa-miR-101-3p, hsa-miR-15a-5p, hsa-miR-29c-3p, hsa-miR-144-3p and hsa-miR-19b-3p were lower in non-responders. Hsa-miR-19b-3p was the variable associated with the response to BS in a logistic regression model. Conclusions: The mental health of patients after BS is limited by the success of the intervention. In addition, the expression of basal serum miRNAs related to depression/anxiety could predict the success of BS.
publishDate	2023
dc.date.none.fl_str_mv	2023
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://hdl.handle.net/2445/209237
url	https://hdl.handle.net/2445/209237
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	Reproducció del document publicat a: https://doi.org/10.3390/nu15194109 Nutrients, 2023, vol. 15, num.19 https://doi.org/10.3390/nu15194109
dc.rights.none.fl_str_mv	cc-by (c) Mela, V. et al., 2023 http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess
rights_invalid_str_mv	cc-by (c) Mela, V. et al., 2023 http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	MDPI
publisher.none.fl_str_mv	MDPI
dc.source.none.fl_str_mv	Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil) reponame:Dipòsit Digital de la UB instname:Universidad de Barcelona
instname_str	Universidad de Barcelona
reponame_str	Dipòsit Digital de la UB
collection	Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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The relationship between depressive symptoms, quality of life and miRNAs 8 years after bariatric surgery

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