Atorvastatin-loaded peptide amphiphiles against corneal neovascularization

Background: Corneal neovascularization is a sight-threatening disease. It can be treated using antiangiogenic and anti-inflammatory compounds. Therefore, atorvastatin (ATV) constitutes a suitable candidate to be administered topically. To attain suitable efficacy, ATV can be encapsulated into custom...

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Detalles Bibliográficos
Autores: Sánchez-López, Elena, Gómara, Maria José, Haro Villar, Isabel
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/335325
Acceso en línea:http://hdl.handle.net/10261/335325
https://api.elsevier.com/content/abstract/scopus_id/85170110120
Access Level:acceso abierto
Palabra clave:Peptide amphiphiles
Angiogenesis
Atorvastatin
Drug delivery
Ocular inflammation
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
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spelling Atorvastatin-loaded peptide amphiphiles against corneal neovascularizationSánchez-López, ElenaGómara, Maria JoséHaro Villar, IsabelPeptide amphiphilesAngiogenesisAtorvastatinDrug deliveryOcular inflammationhttp://metadata.un.org/sdg/3Ensure healthy lives and promote well-being for all at all agesBackground: Corneal neovascularization is a sight-threatening disease. It can be treated using antiangiogenic and anti-inflammatory compounds. Therefore, atorvastatin (ATV) constitutes a suitable candidate to be administered topically. To attain suitable efficacy, ATV can be encapsulated into custom-developed nanocarriers such as peptide amphiphiles. Methods: Three peptide amphiphiles bearing one, two or four C16-alkyl groups (mC16-Tat47-57, dC16-Tat47-57 and qC16-Tat47-57) were synthesized, characterized and loaded with ATV. Drug release and ocular tolerance were assessed as well as anti-inflammatory and antiangiogenic properties. Results: ATV-qC16-Tat47-57 showed higher encapsulation efficiency than mC16-Tat47-57 and dC16-Tat47-57 and more defined nanostructures. ATV-qC16-Tat47-57 showed ATV prolonged release with suitable ocular tolerance. Moreover, ATV-qC16-Tat47-57 was antiangiogenic and prevented ocular inflammation. Conclusion: ATV-qC16-Tat47-57 constitutes a promising topical medication against corneal neovascularization.The authors acknowledge M Cortada and AS Clares for their participation. E Sanchez-Lopez acknowledges the support of the Requalification of the Spanish University System Program. Financial & competing interests disclosure. This research was funded by the Spanish Ministry of Economy, Industry and Competitiveness and the European Regional Development Fund (grants RTI2018-094120-B-I00, PID2021-122216OB-I00 and PID2021-122187NB-C32). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.Peer reviewedFuture Medicine0000-0003-2571-108X0000-0002-6906-48330000-0001-8677-2340Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202320232023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/335325https://api.elsevier.com/content/abstract/scopus_id/85170110120reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésNanomedicine (London, England)https://doi.org/10.2217/nnm-2023-0133Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3353252026-05-22T06:33:51Z
dc.title.none.fl_str_mv Atorvastatin-loaded peptide amphiphiles against corneal neovascularization
title Atorvastatin-loaded peptide amphiphiles against corneal neovascularization
spellingShingle Atorvastatin-loaded peptide amphiphiles against corneal neovascularization
Sánchez-López, Elena
Peptide amphiphiles
Angiogenesis
Atorvastatin
Drug delivery
Ocular inflammation
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
title_short Atorvastatin-loaded peptide amphiphiles against corneal neovascularization
title_full Atorvastatin-loaded peptide amphiphiles against corneal neovascularization
title_fullStr Atorvastatin-loaded peptide amphiphiles against corneal neovascularization
title_full_unstemmed Atorvastatin-loaded peptide amphiphiles against corneal neovascularization
title_sort Atorvastatin-loaded peptide amphiphiles against corneal neovascularization
dc.creator.none.fl_str_mv Sánchez-López, Elena
Gómara, Maria José
Haro Villar, Isabel
author Sánchez-López, Elena
author_facet Sánchez-López, Elena
Gómara, Maria José
Haro Villar, Isabel
author_role author
author2 Gómara, Maria José
Haro Villar, Isabel
author2_role author
author
dc.contributor.none.fl_str_mv 0000-0003-2571-108X
0000-0002-6906-4833
0000-0001-8677-2340
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Peptide amphiphiles
Angiogenesis
Atorvastatin
Drug delivery
Ocular inflammation
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
topic Peptide amphiphiles
Angiogenesis
Atorvastatin
Drug delivery
Ocular inflammation
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
description Background: Corneal neovascularization is a sight-threatening disease. It can be treated using antiangiogenic and anti-inflammatory compounds. Therefore, atorvastatin (ATV) constitutes a suitable candidate to be administered topically. To attain suitable efficacy, ATV can be encapsulated into custom-developed nanocarriers such as peptide amphiphiles. Methods: Three peptide amphiphiles bearing one, two or four C16-alkyl groups (mC16-Tat47-57, dC16-Tat47-57 and qC16-Tat47-57) were synthesized, characterized and loaded with ATV. Drug release and ocular tolerance were assessed as well as anti-inflammatory and antiangiogenic properties. Results: ATV-qC16-Tat47-57 showed higher encapsulation efficiency than mC16-Tat47-57 and dC16-Tat47-57 and more defined nanostructures. ATV-qC16-Tat47-57 showed ATV prolonged release with suitable ocular tolerance. Moreover, ATV-qC16-Tat47-57 was antiangiogenic and prevented ocular inflammation. Conclusion: ATV-qC16-Tat47-57 constitutes a promising topical medication against corneal neovascularization.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/335325
https://api.elsevier.com/content/abstract/scopus_id/85170110120
url http://hdl.handle.net/10261/335325
https://api.elsevier.com/content/abstract/scopus_id/85170110120
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Nanomedicine (London, England)
https://doi.org/10.2217/nnm-2023-0133
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Future Medicine
publisher.none.fl_str_mv Future Medicine
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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