Monocyte-endothelial cell interactions in vascular and tissue remodeling

Monocytes are circulating leukocytes of innate immunity derived from the bone marrow that interact with endothelial cells under physiological or pathophysiological conditions to orchestrate inflammation, angiogenesis, or tissue remodeling. Monocytes are attracted by chemokines and specific receptors...

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Detalhes bibliográficos
Autores: Medrano Bosch, Mireia, Simón Codina, Blanca, Jiménez, Wladimiro, Edelman, Elazer R., Melgar-Lesmes, Pedro
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Recursos:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/219284
Acesso em linha:https://hdl.handle.net/2445/219284
Access Level:acceso abierto
Palavra-chave:Malalties cardiovasculars
Malalties del fetge
Macròfags
Angiogènesi
Tumors
Cardiovascular diseases
Liver diseases
Macrophages
Neovascularization
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spelling Monocyte-endothelial cell interactions in vascular and tissue remodelingMedrano Bosch, MireiaSimón Codina, BlancaJiménez, WladimiroEdelman, Elazer R.Melgar-Lesmes, PedroMalalties cardiovascularsMalalties del fetgeMacròfagsAngiogènesiTumorsCardiovascular diseasesLiver diseasesMacrophagesNeovascularizationTumorsMonocytes are circulating leukocytes of innate immunity derived from the bone marrow that interact with endothelial cells under physiological or pathophysiological conditions to orchestrate inflammation, angiogenesis, or tissue remodeling. Monocytes are attracted by chemokines and specific receptors to precise areas in vessels or tissues and transdifferentiate into macrophages with tissue damage or infection. Adherent monocytes and infiltrated monocyte-derived macrophages locally release a myriad of cytokines, vasoactive agents, matrix metalloproteinases, and growth factors to induce vascular and tissue remodeling or for propagation of inflammatory responses. Infiltrated macrophages cooperate with tissue-resident macrophages during all the phases of tissue injury, repair, and regeneration. Substances released by infiltrated and resident macrophages serve not only to coordinate vessel and tissue growth but cellular interactions as well by attracting more circulating monocytes (e.g. MCP-1) and stimulating nearby endothelial cells (e.g. TNF-α) to expose monocyte adhesion molecules. Prolonged tissue accumulation and activation of infiltrated monocytes may result in alterations in extracellular matrix turnover, tissue functions, and vascular leakage. In this review, we highlight the link between interactions of infiltrating monocytes and endothelial cells to regulate vascular and tissue remodeling with a special focus on how these interactions contribute to pathophysiological conditions such as cardiovascular and chronic liver diseases.Frontiers Media2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/219284Articles publicats en revistes (Biomedicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3389/fimmu.2023.1196033Frontiers in Immunology, 2023, num.14https://doi.org/10.3389/fimmu.2023.1196033cc-by (c) Medrano-Bosch M et al., 2023http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2192842026-05-27T06:46:51Z
dc.title.none.fl_str_mv Monocyte-endothelial cell interactions in vascular and tissue remodeling
title Monocyte-endothelial cell interactions in vascular and tissue remodeling
spellingShingle Monocyte-endothelial cell interactions in vascular and tissue remodeling
Medrano Bosch, Mireia
Malalties cardiovasculars
Malalties del fetge
Macròfags
Angiogènesi
Tumors
Cardiovascular diseases
Liver diseases
Macrophages
Neovascularization
Tumors
title_short Monocyte-endothelial cell interactions in vascular and tissue remodeling
title_full Monocyte-endothelial cell interactions in vascular and tissue remodeling
title_fullStr Monocyte-endothelial cell interactions in vascular and tissue remodeling
title_full_unstemmed Monocyte-endothelial cell interactions in vascular and tissue remodeling
title_sort Monocyte-endothelial cell interactions in vascular and tissue remodeling
dc.creator.none.fl_str_mv Medrano Bosch, Mireia
Simón Codina, Blanca
Jiménez, Wladimiro
Edelman, Elazer R.
Melgar-Lesmes, Pedro
author Medrano Bosch, Mireia
author_facet Medrano Bosch, Mireia
Simón Codina, Blanca
Jiménez, Wladimiro
Edelman, Elazer R.
Melgar-Lesmes, Pedro
author_role author
author2 Simón Codina, Blanca
Jiménez, Wladimiro
Edelman, Elazer R.
Melgar-Lesmes, Pedro
author2_role author
author
author
author
dc.subject.none.fl_str_mv Malalties cardiovasculars
Malalties del fetge
Macròfags
Angiogènesi
Tumors
Cardiovascular diseases
Liver diseases
Macrophages
Neovascularization
Tumors
topic Malalties cardiovasculars
Malalties del fetge
Macròfags
Angiogènesi
Tumors
Cardiovascular diseases
Liver diseases
Macrophages
Neovascularization
Tumors
description Monocytes are circulating leukocytes of innate immunity derived from the bone marrow that interact with endothelial cells under physiological or pathophysiological conditions to orchestrate inflammation, angiogenesis, or tissue remodeling. Monocytes are attracted by chemokines and specific receptors to precise areas in vessels or tissues and transdifferentiate into macrophages with tissue damage or infection. Adherent monocytes and infiltrated monocyte-derived macrophages locally release a myriad of cytokines, vasoactive agents, matrix metalloproteinases, and growth factors to induce vascular and tissue remodeling or for propagation of inflammatory responses. Infiltrated macrophages cooperate with tissue-resident macrophages during all the phases of tissue injury, repair, and regeneration. Substances released by infiltrated and resident macrophages serve not only to coordinate vessel and tissue growth but cellular interactions as well by attracting more circulating monocytes (e.g. MCP-1) and stimulating nearby endothelial cells (e.g. TNF-α) to expose monocyte adhesion molecules. Prolonged tissue accumulation and activation of infiltrated monocytes may result in alterations in extracellular matrix turnover, tissue functions, and vascular leakage. In this review, we highlight the link between interactions of infiltrating monocytes and endothelial cells to regulate vascular and tissue remodeling with a special focus on how these interactions contribute to pathophysiological conditions such as cardiovascular and chronic liver diseases.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/219284
url https://hdl.handle.net/2445/219284
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3389/fimmu.2023.1196033
Frontiers in Immunology, 2023, num.14
https://doi.org/10.3389/fimmu.2023.1196033
dc.rights.none.fl_str_mv cc-by (c) Medrano-Bosch M et al., 2023
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Medrano-Bosch M et al., 2023
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Articles publicats en revistes (Biomedicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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