Tagging long-lived individuals through vitamin-D receptor (VDR) haplotypes

Longevity is a complex phenomenon involving multiple environmental and biological factors. Genetic studies of longevity have focussed on DNA repair, oxidative damage correction and immune-related genes. Vitamin-D works by modulating mineral homeostasis and key physiological processes such as cell pr...

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Detalles Bibliográficos
Autores: Laplana, Marina, Sánchez de la Torre, Manuel, Aguiló, Alicia, Casado, Ignasi, Flores, Miquel, Sánchez Pellicer, Ramón, Fibla Palazón, Joan
Tipo de recurso: artículo
Fecha de publicación:2010
País:España
Institución:Universidad de Castilla-La Mancha
Repositorio:RUIdeRA. Repositorio Institucional de la UCLM
OAI Identifier:oai:ruidera.uclm.es:10578/41097
Acceso en línea:https://hdl.handle.net/10578/41097
Access Level:acceso abierto
Palabra clave:Haplotypes
Longevity
Octogenarians
Polymorphism
VDR
Vitamin-D
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spelling Tagging long-lived individuals through vitamin-D receptor (VDR) haplotypesLaplana, MarinaSánchez de la Torre, ManuelAguiló, AliciaCasado, IgnasiFlores, MiquelSánchez Pellicer, RamónFibla Palazón, JoanHaplotypesLongevityOctogenariansPolymorphismVDRVitamin-DLongevity is a complex phenomenon involving multiple environmental and biological factors. Genetic studies of longevity have focussed on DNA repair, oxidative damage correction and immune-related genes. Vitamin-D works by modulating mineral homeostasis and key physiological processes such as cell proliferation and immune response. Vitamin-D insufficiency has been largely considered a risk factor for life-limiting illnesses including cardiovascular and immune-related diseases and cancer. Vitamin-D acts through vitamin-D-receptor (VDR), which regulates the expression of vitamin-D-response genes. VDR variants have been associated with susceptibility to cancer, bacterial and viral infections, autoimmune diseases, and allergies. In the present study we evaluated VDR as candidate gene involved in human longevity. We selected five polymorphisms of the VDR gene that capture variability at the 5, coding and 3 regions. Genotype data was obtained from 104 octogenarians (>85 years) and 114 controls (17-40 years). Although differences in genotype and allele distribution did not reach statistical significance, haplotype distribution was distinctive, mainly for 3 region haplotypes and particularly in males. Our results suggest a role for VDR gene variability in aging and longevity.Springer Nataure202520252010info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://hdl.handle.net/10578/41097reponame:RUIdeRA. Repositorio Institucional de la UCLMinstname:Universidad de Castilla-La ManchaInglésinfo:eu-repo/semantics/openAccessoai:ruidera.uclm.es:10578/410972026-05-27T07:36:41Z
dc.title.none.fl_str_mv Tagging long-lived individuals through vitamin-D receptor (VDR) haplotypes
title Tagging long-lived individuals through vitamin-D receptor (VDR) haplotypes
spellingShingle Tagging long-lived individuals through vitamin-D receptor (VDR) haplotypes
Laplana, Marina
Haplotypes
Longevity
Octogenarians
Polymorphism
VDR
Vitamin-D
title_short Tagging long-lived individuals through vitamin-D receptor (VDR) haplotypes
title_full Tagging long-lived individuals through vitamin-D receptor (VDR) haplotypes
title_fullStr Tagging long-lived individuals through vitamin-D receptor (VDR) haplotypes
title_full_unstemmed Tagging long-lived individuals through vitamin-D receptor (VDR) haplotypes
title_sort Tagging long-lived individuals through vitamin-D receptor (VDR) haplotypes
dc.creator.none.fl_str_mv Laplana, Marina
Sánchez de la Torre, Manuel
Aguiló, Alicia
Casado, Ignasi
Flores, Miquel
Sánchez Pellicer, Ramón
Fibla Palazón, Joan
author Laplana, Marina
author_facet Laplana, Marina
Sánchez de la Torre, Manuel
Aguiló, Alicia
Casado, Ignasi
Flores, Miquel
Sánchez Pellicer, Ramón
Fibla Palazón, Joan
author_role author
author2 Sánchez de la Torre, Manuel
Aguiló, Alicia
Casado, Ignasi
Flores, Miquel
Sánchez Pellicer, Ramón
Fibla Palazón, Joan
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Haplotypes
Longevity
Octogenarians
Polymorphism
VDR
Vitamin-D
topic Haplotypes
Longevity
Octogenarians
Polymorphism
VDR
Vitamin-D
description Longevity is a complex phenomenon involving multiple environmental and biological factors. Genetic studies of longevity have focussed on DNA repair, oxidative damage correction and immune-related genes. Vitamin-D works by modulating mineral homeostasis and key physiological processes such as cell proliferation and immune response. Vitamin-D insufficiency has been largely considered a risk factor for life-limiting illnesses including cardiovascular and immune-related diseases and cancer. Vitamin-D acts through vitamin-D-receptor (VDR), which regulates the expression of vitamin-D-response genes. VDR variants have been associated with susceptibility to cancer, bacterial and viral infections, autoimmune diseases, and allergies. In the present study we evaluated VDR as candidate gene involved in human longevity. We selected five polymorphisms of the VDR gene that capture variability at the 5, coding and 3 regions. Genotype data was obtained from 104 octogenarians (>85 years) and 114 controls (17-40 years). Although differences in genotype and allele distribution did not reach statistical significance, haplotype distribution was distinctive, mainly for 3 region haplotypes and particularly in males. Our results suggest a role for VDR gene variability in aging and longevity.
publishDate 2010
dc.date.none.fl_str_mv 2010
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10578/41097
url https://hdl.handle.net/10578/41097
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer Nataure
publisher.none.fl_str_mv Springer Nataure
dc.source.none.fl_str_mv reponame:RUIdeRA. Repositorio Institucional de la UCLM
instname:Universidad de Castilla-La Mancha
instname_str Universidad de Castilla-La Mancha
reponame_str RUIdeRA. Repositorio Institucional de la UCLM
collection RUIdeRA. Repositorio Institucional de la UCLM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812455

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