Microtubule-associated protein 1B (MAP1B) is required for dendritic spine development and synaptic maturation

Microtubule-associated protein 1B (MAP1B) is prominently expressed during early stages of neuronal development, and it has been implicated in axonal growth and guidance. MAP1B expression is also found in the adult brain in areas of significant synaptic plasticity. Here, we demonstrate that MAP1B is...

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Autores: Tortosa, Elena, Montenegro-Venegas, Carolina, Benoist, Marion, Härtel, Steffen, González-Billault, Christian, Esteban, José A., Ávila, Jesús
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2011
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/252151
Acceso en línea:http://hdl.handle.net/10261/252151
Access Level:acceso abierto
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spelling Microtubule-associated protein 1B (MAP1B) is required for dendritic spine development and synaptic maturationTortosa, ElenaMontenegro-Venegas, CarolinaBenoist, MarionHärtel, SteffenGonzález-Billault, ChristianEsteban, José A.Ávila, JesúsMicrotubule-associated protein 1B (MAP1B) is prominently expressed during early stages of neuronal development, and it has been implicated in axonal growth and guidance. MAP1B expression is also found in the adult brain in areas of significant synaptic plasticity. Here, we demonstrate that MAP1B is present in dendritic spines, and we describe a decrease in the density of mature dendritic spines in neurons of MAP1B-deficient mice that was accompanied by an increase in the number of immature filopodia-like protrusions. Although these neurons exhibited normal passive membrane properties and action potential firing, AMPA receptor-mediated synaptic currents were significantly diminished. Moreover, we observed a significant decrease in Rac1 activity and an increase in RhoA activity in the postsynaptic densities of adult MAP1B+/- mice when compared with wild type controls. MAP1B+/- fractions also exhibited a decrease in phosphorylated cofilin. Taken together, these results indicate a new and important role for MAP1B in the formation and maturation of dendritic spines, possibly through the regulation of the actin cytoskeleton. This activity of MAP1B could contribute to the regulation of synaptic activity and plasticity in the adult brain. © 2011 by The American Society for Biochemistry and Molecular Biology, Inc.American Society for Biochemistry and Molecular BiologyConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2021202120112021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/252151reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1074/jbc.M111.271320Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2521512026-05-22T06:33:51Z
dc.title.none.fl_str_mv Microtubule-associated protein 1B (MAP1B) is required for dendritic spine development and synaptic maturation
title Microtubule-associated protein 1B (MAP1B) is required for dendritic spine development and synaptic maturation
spellingShingle Microtubule-associated protein 1B (MAP1B) is required for dendritic spine development and synaptic maturation
Tortosa, Elena
title_short Microtubule-associated protein 1B (MAP1B) is required for dendritic spine development and synaptic maturation
title_full Microtubule-associated protein 1B (MAP1B) is required for dendritic spine development and synaptic maturation
title_fullStr Microtubule-associated protein 1B (MAP1B) is required for dendritic spine development and synaptic maturation
title_full_unstemmed Microtubule-associated protein 1B (MAP1B) is required for dendritic spine development and synaptic maturation
title_sort Microtubule-associated protein 1B (MAP1B) is required for dendritic spine development and synaptic maturation
dc.creator.none.fl_str_mv Tortosa, Elena
Montenegro-Venegas, Carolina
Benoist, Marion
Härtel, Steffen
González-Billault, Christian
Esteban, José A.
Ávila, Jesús
author Tortosa, Elena
author_facet Tortosa, Elena
Montenegro-Venegas, Carolina
Benoist, Marion
Härtel, Steffen
González-Billault, Christian
Esteban, José A.
Ávila, Jesús
author_role author
author2 Montenegro-Venegas, Carolina
Benoist, Marion
Härtel, Steffen
González-Billault, Christian
Esteban, José A.
Ávila, Jesús
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
description Microtubule-associated protein 1B (MAP1B) is prominently expressed during early stages of neuronal development, and it has been implicated in axonal growth and guidance. MAP1B expression is also found in the adult brain in areas of significant synaptic plasticity. Here, we demonstrate that MAP1B is present in dendritic spines, and we describe a decrease in the density of mature dendritic spines in neurons of MAP1B-deficient mice that was accompanied by an increase in the number of immature filopodia-like protrusions. Although these neurons exhibited normal passive membrane properties and action potential firing, AMPA receptor-mediated synaptic currents were significantly diminished. Moreover, we observed a significant decrease in Rac1 activity and an increase in RhoA activity in the postsynaptic densities of adult MAP1B+/- mice when compared with wild type controls. MAP1B+/- fractions also exhibited a decrease in phosphorylated cofilin. Taken together, these results indicate a new and important role for MAP1B in the formation and maturation of dendritic spines, possibly through the regulation of the actin cytoskeleton. This activity of MAP1B could contribute to the regulation of synaptic activity and plasticity in the adult brain. © 2011 by The American Society for Biochemistry and Molecular Biology, Inc.
publishDate 2011
dc.date.none.fl_str_mv 2011
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/252151
url http://hdl.handle.net/10261/252151
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1074/jbc.M111.271320
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Society for Biochemistry and Molecular Biology
publisher.none.fl_str_mv American Society for Biochemistry and Molecular Biology
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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