Nutritional effects of folic acid controlled release from mesoporous materials
[EN] Folic acid deficiency causes serious disorders in humans and supplementation has numerous health benefits. However, there is initial evidence that suggest a negative impact of an increased exposure to folic with respect to certain developmental and degenerative disorders. In this line, controll...
| Autores: | , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2011 |
| País: | España |
| Institución: | Universitat Politècnica de València (UPV) |
| Repositorio: | RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia |
| Idioma: | inglés |
| OAI Identifier: | oai:riunet.upv.es:10251/75377 |
| Acceso en línea: | https://riunet.upv.es/handle/10251/75377 |
| Access Level: | acceso abierto |
| Palabra clave: | Folic acid Control release Mesoporous material Bioavailability Molecular gates QUIMICA INORGANICA TECNOLOGIA DE ALIMENTOS |
| Sumario: | [EN] Folic acid deficiency causes serious disorders in humans and supplementation has numerous health benefits. However, there is initial evidence that suggest a negative impact of an increased exposure to folic with respect to certain developmental and degenerative disorders. In this line, controlled release of folic acid by using mesoporous silica materials, MCM-41, has been studied as an alternative to direct supplementation. For this purpose, various mesoporous solids MCM-41 loaded with folic acid (S1) and functionalized with 3-[2-(2-aminoethylamino)ethylamino]propyl-trimethoxysilane (S2) acting as "gate" have been tested. The results show that at pH 2 a strongly hindered vitamin release is observed, whereas at pH 7.5 a controlled delivery is found. Based on the obtained results of this study, folic acid controlled release could be feasible during a period of 5h using a sensitive to pH gate, and this might reduce traditional fortification negative effects, while nutritional benefits are maintained |
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