Penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus

© 2014 IUBMB Life, 66(8):572-577, 2014 © 2014 International Union of Biochemistry and Molecular Biology. High-level resistance to β-lactam antibiotics in methicillin-resistant Staphylococcus aureus (MRSA) is due to expression of penicillin-binding protein 2a (PBP2a), a transpeptidase that catalyzes...

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Detalles Bibliográficos
Autores: Fishovitz, J., Hermoso, Juan A., Chang, M., Mobashery, S.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/167797
Acceso en línea:http://hdl.handle.net/10261/167797
Access Level:acceso abierto
Descripción
Sumario:© 2014 IUBMB Life, 66(8):572-577, 2014 © 2014 International Union of Biochemistry and Molecular Biology. High-level resistance to β-lactam antibiotics in methicillin-resistant Staphylococcus aureus (MRSA) is due to expression of penicillin-binding protein 2a (PBP2a), a transpeptidase that catalyzes cell-wall crosslinking in the face of the challenge by β-lactam antibiotics. The activity of this protein is regulated by allostery at a site 60 Å distant from the active site, where crosslinking of cell wall takes place. This review discusses the state of knowledge on this important enzyme of cell-wall biosynthesis in MRSA.