The silence of opioids-dependent chronic pain patients: A text mining analysis from sex and gender perspective

Existing evidence indicates sex-related differences in Prescription Opioid Use Disorder (OUD) in Chronic Non-Cancer Pain (CNCP). However to date, there is scant evidence for other socioeconomic factors in these differences. Our aim was to enquire about the influence of gender and drug copayment of O...

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Autores: Carratalá, Claudia, Agulló, Laura, CARRACEDO, PATRICIA, Serrano Gadea, Noelia, Escorial, Mónica, López Mañogil, Elena, Miró, Pau, Bernardes, Sónia F., Peiro, Ana
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universidad Miguel Hernández de Elche
Repositorio:REDIUMH. Depósito Digital de la UMH
OAI Identifier:oai:dspace.umh.es:11000/38885
Acceso en línea:https://hdl.handle.net/11000/38885
Access Level:acceso abierto
Palabra clave:Opioid Use Disorder (OUD)
Sex differences
Chronic Non-Cancer Pain (CNCP)
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spelling The silence of opioids-dependent chronic pain patients: A text mining analysis from sex and gender perspectiveCarratalá, ClaudiaAgulló, LauraCARRACEDO, PATRICIASerrano Gadea, NoeliaEscorial, MónicaLópez Mañogil, ElenaMiró, PauBernardes, Sónia F.Peiro, AnaOpioid Use Disorder (OUD)Sex differencesChronic Non-Cancer Pain (CNCP)Existing evidence indicates sex-related differences in Prescription Opioid Use Disorder (OUD) in Chronic Non-Cancer Pain (CNCP). However to date, there is scant evidence for other socioeconomic factors in these differences. Our aim was to enquire about the influence of gender and drug copayment of OUD narratives by the text mining analysis. A prospective mixed-methods study was designed and performed at Pain Unit (PU) including 238 real world patients with CNCP divided in controls (n = 206) and OUD cases (n = 32) due to DSM-5 diagnosis Variables related to pain, sleep, mental and health status were collected in together with sex and gender interaction, in pain status, along 30-45 min face-to-face interviews. Sex differences were observed due to women's significantly older ages, with a stronger impact on mental health, and an even stronger one for the OUD women. Globally, OUD cases were more unemployed vs the CNCP controls, and on a significantly higher median opioid daily dose of 90 [100] mg/day. Although OUD participants did more social activities, they tended to use less vocabulary to express themselves regardless of their sex, gender role or economic status. In contrast, the CNCP participants presented more differences driven by their incomes, with "limited" being the most discriminating word for those on low income, followed by "less" and "help". Here, the most significant word of CNCP women was "husband", followed by "tasks". In contrast, gender reproductive roles shared similarities in both sexes, being one of the most discriminatory words "help". The data show that OUD patients seem to have a marked influence of OUD on poorer lexicon and simpler narrative, together with a significant impact of socioeconomic factors on the CNCP narratives. The conclusion suggests to extend the research to better understand the effect of sex, gender and socioeconomic status in CNCP especially on OUD women's health.PLOS ONEDepartamentos de la UMH::Farmacología, Pediatría y Química Orgánica202620262025info:eu-repo/semantics/articleapplication/pdf17application/pdfhttps://hdl.handle.net/11000/38885reponame:REDIUMH. Depósito Digital de la UMHinstname:Universidad Miguel Hernández de ElcheInglés10.1371/journal.pone.0319574info:eu-repo/semantics/openAccessAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/oai:dspace.umh.es:11000/388852026-05-27T13:36:21Z
dc.title.none.fl_str_mv The silence of opioids-dependent chronic pain patients: A text mining analysis from sex and gender perspective
title The silence of opioids-dependent chronic pain patients: A text mining analysis from sex and gender perspective
spellingShingle The silence of opioids-dependent chronic pain patients: A text mining analysis from sex and gender perspective
Carratalá, Claudia
Opioid Use Disorder (OUD)
Sex differences
Chronic Non-Cancer Pain (CNCP)
title_short The silence of opioids-dependent chronic pain patients: A text mining analysis from sex and gender perspective
title_full The silence of opioids-dependent chronic pain patients: A text mining analysis from sex and gender perspective
title_fullStr The silence of opioids-dependent chronic pain patients: A text mining analysis from sex and gender perspective
title_full_unstemmed The silence of opioids-dependent chronic pain patients: A text mining analysis from sex and gender perspective
title_sort The silence of opioids-dependent chronic pain patients: A text mining analysis from sex and gender perspective
dc.creator.none.fl_str_mv Carratalá, Claudia
Agulló, Laura
CARRACEDO, PATRICIA
Serrano Gadea, Noelia
Escorial, Mónica
López Mañogil, Elena
Miró, Pau
Bernardes, Sónia F.
Peiro, Ana
author Carratalá, Claudia
author_facet Carratalá, Claudia
Agulló, Laura
CARRACEDO, PATRICIA
Serrano Gadea, Noelia
Escorial, Mónica
López Mañogil, Elena
Miró, Pau
Bernardes, Sónia F.
Peiro, Ana
author_role author
author2 Agulló, Laura
CARRACEDO, PATRICIA
Serrano Gadea, Noelia
Escorial, Mónica
López Mañogil, Elena
Miró, Pau
Bernardes, Sónia F.
Peiro, Ana
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamentos de la UMH::Farmacología, Pediatría y Química Orgánica
dc.subject.none.fl_str_mv Opioid Use Disorder (OUD)
Sex differences
Chronic Non-Cancer Pain (CNCP)
topic Opioid Use Disorder (OUD)
Sex differences
Chronic Non-Cancer Pain (CNCP)
description Existing evidence indicates sex-related differences in Prescription Opioid Use Disorder (OUD) in Chronic Non-Cancer Pain (CNCP). However to date, there is scant evidence for other socioeconomic factors in these differences. Our aim was to enquire about the influence of gender and drug copayment of OUD narratives by the text mining analysis. A prospective mixed-methods study was designed and performed at Pain Unit (PU) including 238 real world patients with CNCP divided in controls (n = 206) and OUD cases (n = 32) due to DSM-5 diagnosis Variables related to pain, sleep, mental and health status were collected in together with sex and gender interaction, in pain status, along 30-45 min face-to-face interviews. Sex differences were observed due to women's significantly older ages, with a stronger impact on mental health, and an even stronger one for the OUD women. Globally, OUD cases were more unemployed vs the CNCP controls, and on a significantly higher median opioid daily dose of 90 [100] mg/day. Although OUD participants did more social activities, they tended to use less vocabulary to express themselves regardless of their sex, gender role or economic status. In contrast, the CNCP participants presented more differences driven by their incomes, with "limited" being the most discriminating word for those on low income, followed by "less" and "help". Here, the most significant word of CNCP women was "husband", followed by "tasks". In contrast, gender reproductive roles shared similarities in both sexes, being one of the most discriminatory words "help". The data show that OUD patients seem to have a marked influence of OUD on poorer lexicon and simpler narrative, together with a significant impact of socioeconomic factors on the CNCP narratives. The conclusion suggests to extend the research to better understand the effect of sex, gender and socioeconomic status in CNCP especially on OUD women's health.
publishDate 2025
dc.date.none.fl_str_mv 2025
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/11000/38885
url https://hdl.handle.net/11000/38885
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv 10.1371/journal.pone.0319574
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.format.none.fl_str_mv application/pdf
17
application/pdf
dc.publisher.none.fl_str_mv PLOS ONE
publisher.none.fl_str_mv PLOS ONE
dc.source.none.fl_str_mv reponame:REDIUMH. Depósito Digital de la UMH
instname:Universidad Miguel Hernández de Elche
instname_str Universidad Miguel Hernández de Elche
reponame_str REDIUMH. Depósito Digital de la UMH
collection REDIUMH. Depósito Digital de la UMH
repository.name.fl_str_mv
repository.mail.fl_str_mv
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