Efficacy and safety of medical treatment of primary aldosteronism: a real-world data study in Spain

Goi, J. (Jessica)|||/items/805408b2-cc7b-4a42-96d2-1ff7afb35c4e; Paja, M. (Miguel)|||/items/7363db50-6d05-4cc5-9ce0-7ef843ec77a9; Rizo-Gellida, A. (Alicia)|||/items/f8a92d62-01bb-463e-87e6-0bda3a8280f4; González-Boillos, M. (Marga)|||/items/14f47f15-0a8b-4767-ab55-ea0aded977ac; Martín-Rojas-Marcos, P. (Patricia)|||/items/2952c4f1-d2b5-421b-97f7-c957ee865b04; Caja-Guayerbas, L. (Laura)|||/items/5f232a15-5671-4caf-b781-bdf334c309c4; García-Cano, A.M. (Ana María)|||/items/0c1a6ede-96d1-4153-9998-690a803e2b55; Ruiz-Sanchez, J.G. (Jorge Gabriel)|||/items/ef42b270-6a01-45f8-b044-f27c8fb943bd; Vicente, A. (Almudena)|||/items/9bcf3945-5ab8-4943-867f-7e938ff96513; Gómez-Hoyos, E. (Emilia)|||/items/3b973185-2531-45e0-b301-01991f8c9b77; Recasens, M. (Mónica)|||/items/b3281727-5780-40f6-ba02-7fa743c22e40; Barahona-San-Millan, R. (Rebeca)|||/items/527db164-4619-4d85-b926-4b6f24c76bbe; Picón-César, M.J. (María José)|||/items/cc85f8bd-4d6a-4154-9926-e9d41ed8a29c; Díaz-Guardiola, P. (Patricia)|||/items/958e2021-db10-4964-9ad9-e855e4626ccd; Perdomo-Zelaya, C.M. (Carolina María)|||/items/4197cb06-662e-44da-bef0-348099c09dcd; Manjón, L. (Laura)|||/items/d15f30f7-fd73-4d9d-8b50-3f23d8a93c0f; Rebollo-Román, A. (Angel)|||/items/c80baf90-012b-4651-8d31-25e1356a0694; Robles-Lázaro, C. (Cristina)|||/items/b1e66a15-6a19-4e31-8597-a43a0cb04746; María-Recio, J. (José)|||/items/51db7c9f-2cb7-489d-b2e1-b87f7dde9004; Calatayud, M. (Maria)|||/items/83518338-0d4a-4487-a5ab-04d2fe03e907; Jiménez-López, N. (Noemi)|||/items/ade06492-a603-4b38-8b8a-ac36c55e4772; Sampedro-Nuñez, M.A. (Miguel Antonio)|||/items/ebe0283a-614e-4b38-a4a2-b136e5f529c4; Mena-Ribas, E. (Elena)|||/items/18ff8f89-b8fc-4fa2-92c9-433cf7945b08; Sanmartín-Sánchez, A. (Alicia)|||/items/0e8b64e5-e76b-4dde-a559-050e69303517; Gonzalvo-Diaz, C. (César)|||/items/bbc4e225-d0fd-46b9-8bc2-030587915a21; Llamas-Rey, C. (Cristina)|||/items/a8ccc2ef-8b0f-4f2c-b7ea-ab12877dadb8; Serrano, J. (Joaquín)|||/items/3978953f-1c47-4457-be86-a0e3d55df432; Michalopoulou, T. (Theodora)|||/items/b4bc510b-e718-471b-b8f3-969c0868de50; Tenés-Rodrigo, S. (Susana)|||/items/c3296936-a3ae-4b15-b255-d8b28bfb3838; Pascual-Corrales, E. (Eider)|||/items/179fc326-5dc6-4a13-83a6-ea53b6cf9a73; Jaén-Aguila, F. (Fernando)|||/items/11cfcb4b-ed3e-448f-a610-211dcf11dd70; Muñoz-Rivas, N. (Nuria)|||/items/bd3efb7d-986d-434c-a0e0-fdbda5ba328d; Moya-Mateo, E.M. (Eva María)|||/items/a2401f21-6f2d-45bb-95f2-df47cfa3a9ab; Gutiérrez-Medina, S. (Sonsoles)|||/items/2cfa931d-4e41-4c98-9856-dc8b08a87419; Hanzu, F. (Felicia)|||/items/18094f90-5b34-4f9f-a644-84baa14d7612; Parra-Ramírez, P. (Paola)|||/items/5910008e-44ca-41b8-8f82-2bd8fd5c6a23; Araujo-Castro, M. (Marta)|||/items/be343957-0b49-450b-9999-b8687cebeba5

Efficacy and safety of medical treatment of primary aldosteronism: a real-world data study in Spain

Objective This study aims to analyze current medical management of primary aldosteronism (PA) in Spain, including doses, adverse events (AEs), and efficacy. Methods SPAIN-ALDO is a national, multicenter, retrospective registry of patients with PA in Spain. For this study, information about medical t...

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Detalles Bibliográficos
Autores:	Goi, J. (Jessica)\|\|\|/items/805408b2-cc7b-4a42-96d2-1ff7afb35c4e, Paja, M. (Miguel)\|\|\|/items/7363db50-6d05-4cc5-9ce0-7ef843ec77a9, Rizo-Gellida, A. (Alicia)\|\|\|/items/f8a92d62-01bb-463e-87e6-0bda3a8280f4, González-Boillos, M. (Marga)\|\|\|/items/14f47f15-0a8b-4767-ab55-ea0aded977ac, Martín-Rojas-Marcos, P. (Patricia)\|\|\|/items/2952c4f1-d2b5-421b-97f7-c957ee865b04, Caja-Guayerbas, L. (Laura)\|\|\|/items/5f232a15-5671-4caf-b781-bdf334c309c4, García-Cano, A.M. (Ana María)\|\|\|/items/0c1a6ede-96d1-4153-9998-690a803e2b55, Ruiz-Sanchez, J.G. (Jorge Gabriel)\|\|\|/items/ef42b270-6a01-45f8-b044-f27c8fb943bd, Vicente, A. (Almudena)\|\|\|/items/9bcf3945-5ab8-4943-867f-7e938ff96513, Gómez-Hoyos, E. (Emilia)\|\|\|/items/3b973185-2531-45e0-b301-01991f8c9b77, Recasens, M. (Mónica)\|\|\|/items/b3281727-5780-40f6-ba02-7fa743c22e40, Barahona-San-Millan, R. (Rebeca)\|\|\|/items/527db164-4619-4d85-b926-4b6f24c76bbe, Picón-César, M.J. (María José)\|\|\|/items/cc85f8bd-4d6a-4154-9926-e9d41ed8a29c, Díaz-Guardiola, P. (Patricia)\|\|\|/items/958e2021-db10-4964-9ad9-e855e4626ccd, Perdomo-Zelaya, C.M. (Carolina María)\|\|\|/items/4197cb06-662e-44da-bef0-348099c09dcd, Manjón, L. (Laura)\|\|\|/items/d15f30f7-fd73-4d9d-8b50-3f23d8a93c0f, Rebollo-Román, A. (Angel)\|\|\|/items/c80baf90-012b-4651-8d31-25e1356a0694, Robles-Lázaro, C. (Cristina)\|\|\|/items/b1e66a15-6a19-4e31-8597-a43a0cb04746, María-Recio, J. (José)\|\|\|/items/51db7c9f-2cb7-489d-b2e1-b87f7dde9004, Calatayud, M. (Maria)\|\|\|/items/83518338-0d4a-4487-a5ab-04d2fe03e907, Jiménez-López, N. (Noemi)\|\|\|/items/ade06492-a603-4b38-8b8a-ac36c55e4772, Sampedro-Nuñez, M.A. (Miguel Antonio)\|\|\|/items/ebe0283a-614e-4b38-a4a2-b136e5f529c4, Mena-Ribas, E. (Elena)\|\|\|/items/18ff8f89-b8fc-4fa2-92c9-433cf7945b08, Sanmartín-Sánchez, A. (Alicia)\|\|\|/items/0e8b64e5-e76b-4dde-a559-050e69303517, Gonzalvo-Diaz, C. (César)\|\|\|/items/bbc4e225-d0fd-46b9-8bc2-030587915a21, Llamas-Rey, C. (Cristina)\|\|\|/items/a8ccc2ef-8b0f-4f2c-b7ea-ab12877dadb8, Serrano, J. (Joaquín)\|\|\|/items/3978953f-1c47-4457-be86-a0e3d55df432, Michalopoulou, T. (Theodora)\|\|\|/items/b4bc510b-e718-471b-b8f3-969c0868de50, Tenés-Rodrigo, S. (Susana)\|\|\|/items/c3296936-a3ae-4b15-b255-d8b28bfb3838, Pascual-Corrales, E. (Eider)\|\|\|/items/179fc326-5dc6-4a13-83a6-ea53b6cf9a73, Jaén-Aguila, F. (Fernando)\|\|\|/items/11cfcb4b-ed3e-448f-a610-211dcf11dd70, Muñoz-Rivas, N. (Nuria)\|\|\|/items/bd3efb7d-986d-434c-a0e0-fdbda5ba328d, Moya-Mateo, E.M. (Eva María)\|\|\|/items/a2401f21-6f2d-45bb-95f2-df47cfa3a9ab, Gutiérrez-Medina, S. (Sonsoles)\|\|\|/items/2cfa931d-4e41-4c98-9856-dc8b08a87419, Hanzu, F. (Felicia)\|\|\|/items/18094f90-5b34-4f9f-a644-84baa14d7612, Parra-Ramírez, P. (Paola)\|\|\|/items/5910008e-44ca-41b8-8f82-2bd8fd5c6a23, Araujo-Castro, M. (Marta)\|\|\|/items/be343957-0b49-450b-9999-b8687cebeba5
Tipo de recurso:	artículo
Fecha de publicación:	2025
País:	España
Institución:	Universidad de Navarra
Repositorio:	Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:	inglés
OAI Identifier:	oai:dadun.unav.edu:10171/122073
Acceso en línea:	https://hdl.handle.net/10171/122073
Access Level:	acceso abierto
Palabra clave:	primary aldosteronism spironolactone eplerenone renin aldosterone

id	ES_f7dcd7c1bbae08b1126ccfc68c3d0326
oai_identifier_str	oai:dadun.unav.edu:10171/122073
network_acronym_str	ES
network_name_str	España
repository_id_str
dc.title.none.fl_str_mv	Efficacy and safety of medical treatment of primary aldosteronism: a real-world data study in Spain
title	Efficacy and safety of medical treatment of primary aldosteronism: a real-world data study in Spain
spellingShingle	Efficacy and safety of medical treatment of primary aldosteronism: a real-world data study in Spain Goi, J. (Jessica)\|\|\|/items/805408b2-cc7b-4a42-96d2-1ff7afb35c4e primary aldosteronism spironolactone eplerenone renin aldosterone
title_short	Efficacy and safety of medical treatment of primary aldosteronism: a real-world data study in Spain
title_full	Efficacy and safety of medical treatment of primary aldosteronism: a real-world data study in Spain
title_fullStr	Efficacy and safety of medical treatment of primary aldosteronism: a real-world data study in Spain
title_full_unstemmed	Efficacy and safety of medical treatment of primary aldosteronism: a real-world data study in Spain
title_sort	Efficacy and safety of medical treatment of primary aldosteronism: a real-world data study in Spain
dc.creator.none.fl_str_mv	Goi, J. (Jessica)\|\|\|/items/805408b2-cc7b-4a42-96d2-1ff7afb35c4e Paja, M. (Miguel)\|\|\|/items/7363db50-6d05-4cc5-9ce0-7ef843ec77a9 Rizo-Gellida, A. (Alicia)\|\|\|/items/f8a92d62-01bb-463e-87e6-0bda3a8280f4 González-Boillos, M. (Marga)\|\|\|/items/14f47f15-0a8b-4767-ab55-ea0aded977ac Martín-Rojas-Marcos, P. (Patricia)\|\|\|/items/2952c4f1-d2b5-421b-97f7-c957ee865b04 Caja-Guayerbas, L. (Laura)\|\|\|/items/5f232a15-5671-4caf-b781-bdf334c309c4 García-Cano, A.M. (Ana María)\|\|\|/items/0c1a6ede-96d1-4153-9998-690a803e2b55 Ruiz-Sanchez, J.G. (Jorge Gabriel)\|\|\|/items/ef42b270-6a01-45f8-b044-f27c8fb943bd Vicente, A. (Almudena)\|\|\|/items/9bcf3945-5ab8-4943-867f-7e938ff96513 Gómez-Hoyos, E. (Emilia)\|\|\|/items/3b973185-2531-45e0-b301-01991f8c9b77 Recasens, M. (Mónica)\|\|\|/items/b3281727-5780-40f6-ba02-7fa743c22e40 Barahona-San-Millan, R. (Rebeca)\|\|\|/items/527db164-4619-4d85-b926-4b6f24c76bbe Picón-César, M.J. (María José)\|\|\|/items/cc85f8bd-4d6a-4154-9926-e9d41ed8a29c Díaz-Guardiola, P. (Patricia)\|\|\|/items/958e2021-db10-4964-9ad9-e855e4626ccd Perdomo-Zelaya, C.M. (Carolina María)\|\|\|/items/4197cb06-662e-44da-bef0-348099c09dcd Manjón, L. (Laura)\|\|\|/items/d15f30f7-fd73-4d9d-8b50-3f23d8a93c0f Rebollo-Román, A. (Angel)\|\|\|/items/c80baf90-012b-4651-8d31-25e1356a0694 Robles-Lázaro, C. (Cristina)\|\|\|/items/b1e66a15-6a19-4e31-8597-a43a0cb04746 María-Recio, J. (José)\|\|\|/items/51db7c9f-2cb7-489d-b2e1-b87f7dde9004 Calatayud, M. (Maria)\|\|\|/items/83518338-0d4a-4487-a5ab-04d2fe03e907 Jiménez-López, N. (Noemi)\|\|\|/items/ade06492-a603-4b38-8b8a-ac36c55e4772 Sampedro-Nuñez, M.A. (Miguel Antonio)\|\|\|/items/ebe0283a-614e-4b38-a4a2-b136e5f529c4 Mena-Ribas, E. (Elena)\|\|\|/items/18ff8f89-b8fc-4fa2-92c9-433cf7945b08 Sanmartín-Sánchez, A. (Alicia)\|\|\|/items/0e8b64e5-e76b-4dde-a559-050e69303517 Gonzalvo-Diaz, C. (César)\|\|\|/items/bbc4e225-d0fd-46b9-8bc2-030587915a21 Llamas-Rey, C. (Cristina)\|\|\|/items/a8ccc2ef-8b0f-4f2c-b7ea-ab12877dadb8 Serrano, J. (Joaquín)\|\|\|/items/3978953f-1c47-4457-be86-a0e3d55df432 Michalopoulou, T. (Theodora)\|\|\|/items/b4bc510b-e718-471b-b8f3-969c0868de50 Tenés-Rodrigo, S. (Susana)\|\|\|/items/c3296936-a3ae-4b15-b255-d8b28bfb3838 Pascual-Corrales, E. (Eider)\|\|\|/items/179fc326-5dc6-4a13-83a6-ea53b6cf9a73 Jaén-Aguila, F. (Fernando)\|\|\|/items/11cfcb4b-ed3e-448f-a610-211dcf11dd70 Muñoz-Rivas, N. (Nuria)\|\|\|/items/bd3efb7d-986d-434c-a0e0-fdbda5ba328d Moya-Mateo, E.M. (Eva María)\|\|\|/items/a2401f21-6f2d-45bb-95f2-df47cfa3a9ab Gutiérrez-Medina, S. (Sonsoles)\|\|\|/items/2cfa931d-4e41-4c98-9856-dc8b08a87419 Hanzu, F. (Felicia)\|\|\|/items/18094f90-5b34-4f9f-a644-84baa14d7612 Parra-Ramírez, P. (Paola)\|\|\|/items/5910008e-44ca-41b8-8f82-2bd8fd5c6a23 Araujo-Castro, M. (Marta)\|\|\|/items/be343957-0b49-450b-9999-b8687cebeba5
author	Goi, J. (Jessica)\|\|\|/items/805408b2-cc7b-4a42-96d2-1ff7afb35c4e
author_facet	Goi, J. (Jessica)\|\|\|/items/805408b2-cc7b-4a42-96d2-1ff7afb35c4e Paja, M. (Miguel)\|\|\|/items/7363db50-6d05-4cc5-9ce0-7ef843ec77a9 Rizo-Gellida, A. (Alicia)\|\|\|/items/f8a92d62-01bb-463e-87e6-0bda3a8280f4 González-Boillos, M. (Marga)\|\|\|/items/14f47f15-0a8b-4767-ab55-ea0aded977ac Martín-Rojas-Marcos, P. (Patricia)\|\|\|/items/2952c4f1-d2b5-421b-97f7-c957ee865b04 Caja-Guayerbas, L. (Laura)\|\|\|/items/5f232a15-5671-4caf-b781-bdf334c309c4 García-Cano, A.M. (Ana María)\|\|\|/items/0c1a6ede-96d1-4153-9998-690a803e2b55 Ruiz-Sanchez, J.G. (Jorge Gabriel)\|\|\|/items/ef42b270-6a01-45f8-b044-f27c8fb943bd Vicente, A. (Almudena)\|\|\|/items/9bcf3945-5ab8-4943-867f-7e938ff96513 Gómez-Hoyos, E. (Emilia)\|\|\|/items/3b973185-2531-45e0-b301-01991f8c9b77 Recasens, M. (Mónica)\|\|\|/items/b3281727-5780-40f6-ba02-7fa743c22e40 Barahona-San-Millan, R. (Rebeca)\|\|\|/items/527db164-4619-4d85-b926-4b6f24c76bbe Picón-César, M.J. (María José)\|\|\|/items/cc85f8bd-4d6a-4154-9926-e9d41ed8a29c Díaz-Guardiola, P. (Patricia)\|\|\|/items/958e2021-db10-4964-9ad9-e855e4626ccd Perdomo-Zelaya, C.M. (Carolina María)\|\|\|/items/4197cb06-662e-44da-bef0-348099c09dcd Manjón, L. (Laura)\|\|\|/items/d15f30f7-fd73-4d9d-8b50-3f23d8a93c0f Rebollo-Román, A. (Angel)\|\|\|/items/c80baf90-012b-4651-8d31-25e1356a0694 Robles-Lázaro, C. (Cristina)\|\|\|/items/b1e66a15-6a19-4e31-8597-a43a0cb04746 María-Recio, J. (José)\|\|\|/items/51db7c9f-2cb7-489d-b2e1-b87f7dde9004 Calatayud, M. (Maria)\|\|\|/items/83518338-0d4a-4487-a5ab-04d2fe03e907 Jiménez-López, N. (Noemi)\|\|\|/items/ade06492-a603-4b38-8b8a-ac36c55e4772 Sampedro-Nuñez, M.A. (Miguel Antonio)\|\|\|/items/ebe0283a-614e-4b38-a4a2-b136e5f529c4 Mena-Ribas, E. (Elena)\|\|\|/items/18ff8f89-b8fc-4fa2-92c9-433cf7945b08 Sanmartín-Sánchez, A. (Alicia)\|\|\|/items/0e8b64e5-e76b-4dde-a559-050e69303517 Gonzalvo-Diaz, C. (César)\|\|\|/items/bbc4e225-d0fd-46b9-8bc2-030587915a21 Llamas-Rey, C. (Cristina)\|\|\|/items/a8ccc2ef-8b0f-4f2c-b7ea-ab12877dadb8 Serrano, J. (Joaquín)\|\|\|/items/3978953f-1c47-4457-be86-a0e3d55df432 Michalopoulou, T. (Theodora)\|\|\|/items/b4bc510b-e718-471b-b8f3-969c0868de50 Tenés-Rodrigo, S. (Susana)\|\|\|/items/c3296936-a3ae-4b15-b255-d8b28bfb3838 Pascual-Corrales, E. (Eider)\|\|\|/items/179fc326-5dc6-4a13-83a6-ea53b6cf9a73 Jaén-Aguila, F. (Fernando)\|\|\|/items/11cfcb4b-ed3e-448f-a610-211dcf11dd70 Muñoz-Rivas, N. (Nuria)\|\|\|/items/bd3efb7d-986d-434c-a0e0-fdbda5ba328d Moya-Mateo, E.M. (Eva María)\|\|\|/items/a2401f21-6f2d-45bb-95f2-df47cfa3a9ab Gutiérrez-Medina, S. (Sonsoles)\|\|\|/items/2cfa931d-4e41-4c98-9856-dc8b08a87419 Hanzu, F. (Felicia)\|\|\|/items/18094f90-5b34-4f9f-a644-84baa14d7612 Parra-Ramírez, P. (Paola)\|\|\|/items/5910008e-44ca-41b8-8f82-2bd8fd5c6a23 Araujo-Castro, M. (Marta)\|\|\|/items/be343957-0b49-450b-9999-b8687cebeba5
author_role	author
author2	Paja, M. (Miguel)\|\|\|/items/7363db50-6d05-4cc5-9ce0-7ef843ec77a9 Rizo-Gellida, A. (Alicia)\|\|\|/items/f8a92d62-01bb-463e-87e6-0bda3a8280f4 González-Boillos, M. (Marga)\|\|\|/items/14f47f15-0a8b-4767-ab55-ea0aded977ac Martín-Rojas-Marcos, P. (Patricia)\|\|\|/items/2952c4f1-d2b5-421b-97f7-c957ee865b04 Caja-Guayerbas, L. (Laura)\|\|\|/items/5f232a15-5671-4caf-b781-bdf334c309c4 García-Cano, A.M. (Ana María)\|\|\|/items/0c1a6ede-96d1-4153-9998-690a803e2b55 Ruiz-Sanchez, J.G. (Jorge Gabriel)\|\|\|/items/ef42b270-6a01-45f8-b044-f27c8fb943bd Vicente, A. (Almudena)\|\|\|/items/9bcf3945-5ab8-4943-867f-7e938ff96513 Gómez-Hoyos, E. (Emilia)\|\|\|/items/3b973185-2531-45e0-b301-01991f8c9b77 Recasens, M. (Mónica)\|\|\|/items/b3281727-5780-40f6-ba02-7fa743c22e40 Barahona-San-Millan, R. (Rebeca)\|\|\|/items/527db164-4619-4d85-b926-4b6f24c76bbe Picón-César, M.J. (María José)\|\|\|/items/cc85f8bd-4d6a-4154-9926-e9d41ed8a29c Díaz-Guardiola, P. (Patricia)\|\|\|/items/958e2021-db10-4964-9ad9-e855e4626ccd Perdomo-Zelaya, C.M. (Carolina María)\|\|\|/items/4197cb06-662e-44da-bef0-348099c09dcd Manjón, L. (Laura)\|\|\|/items/d15f30f7-fd73-4d9d-8b50-3f23d8a93c0f Rebollo-Román, A. (Angel)\|\|\|/items/c80baf90-012b-4651-8d31-25e1356a0694 Robles-Lázaro, C. (Cristina)\|\|\|/items/b1e66a15-6a19-4e31-8597-a43a0cb04746 María-Recio, J. (José)\|\|\|/items/51db7c9f-2cb7-489d-b2e1-b87f7dde9004 Calatayud, M. (Maria)\|\|\|/items/83518338-0d4a-4487-a5ab-04d2fe03e907 Jiménez-López, N. (Noemi)\|\|\|/items/ade06492-a603-4b38-8b8a-ac36c55e4772 Sampedro-Nuñez, M.A. (Miguel Antonio)\|\|\|/items/ebe0283a-614e-4b38-a4a2-b136e5f529c4 Mena-Ribas, E. (Elena)\|\|\|/items/18ff8f89-b8fc-4fa2-92c9-433cf7945b08 Sanmartín-Sánchez, A. (Alicia)\|\|\|/items/0e8b64e5-e76b-4dde-a559-050e69303517 Gonzalvo-Diaz, C. (César)\|\|\|/items/bbc4e225-d0fd-46b9-8bc2-030587915a21 Llamas-Rey, C. (Cristina)\|\|\|/items/a8ccc2ef-8b0f-4f2c-b7ea-ab12877dadb8 Serrano, J. (Joaquín)\|\|\|/items/3978953f-1c47-4457-be86-a0e3d55df432 Michalopoulou, T. (Theodora)\|\|\|/items/b4bc510b-e718-471b-b8f3-969c0868de50 Tenés-Rodrigo, S. (Susana)\|\|\|/items/c3296936-a3ae-4b15-b255-d8b28bfb3838 Pascual-Corrales, E. (Eider)\|\|\|/items/179fc326-5dc6-4a13-83a6-ea53b6cf9a73 Jaén-Aguila, F. (Fernando)\|\|\|/items/11cfcb4b-ed3e-448f-a610-211dcf11dd70 Muñoz-Rivas, N. (Nuria)\|\|\|/items/bd3efb7d-986d-434c-a0e0-fdbda5ba328d Moya-Mateo, E.M. (Eva María)\|\|\|/items/a2401f21-6f2d-45bb-95f2-df47cfa3a9ab Gutiérrez-Medina, S. (Sonsoles)\|\|\|/items/2cfa931d-4e41-4c98-9856-dc8b08a87419 Hanzu, F. (Felicia)\|\|\|/items/18094f90-5b34-4f9f-a644-84baa14d7612 Parra-Ramírez, P. (Paola)\|\|\|/items/5910008e-44ca-41b8-8f82-2bd8fd5c6a23 Araujo-Castro, M. (Marta)\|\|\|/items/be343957-0b49-450b-9999-b8687cebeba5
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv	primary aldosteronism spironolactone eplerenone renin aldosterone
topic	primary aldosteronism spironolactone eplerenone renin aldosterone
description	Objective This study aims to analyze current medical management of primary aldosteronism (PA) in Spain, including doses, adverse events (AEs), and efficacy. Methods SPAIN-ALDO is a national, multicenter, retrospective registry of patients with PA in Spain. For this study, information about medical treatment with mineralocorticoid receptor antagonist (MRA) as first-line or postsurgical therapy and about antihypertensive medications used before PA targeted treatment (MRA or adrenalectomy) was included. We reported surgically and medically treated patients at baseline and at last available follow-up and evaluated clinical and biochemical responses according to Primary Aldosteronism Surgical Outcome (PASO) and Primary Aldosteronism Medical treatment Outcome (PAMO) criteria. Results A total of 997 patients with PA were included. Before PA diagnosis, the classes of antihypertensive drugs most used were calcium-channel blockers (66%) and angiotensin II receptor blockers (48.4%). Of the initial cohort, 880 patients had at least 1 visit available after initiation of MRA (N = 511 as first-line therapy, N = 47 postsurgery) or adrenalectomy (N = 322). The median defined daily dose of MRA therapy was 1.33. Spironolactone was more prescribed than eplerenone (58% vs 42%). Eplerenone was better tolerated than spironolactone (AEs in 4% vs 18%), particularly among males. After a median follow-up of 35 and 17 months for medically and surgically managed patients, the latter achieved a complete biochemical (68.1%) or clinical (33.6%) response more frequently than people under MRA as first-line therapy (48.6% and 15.7%; P < .001). Conclusion This study underscores the need to optimize PA medical management in Spain to improve patient clinical and biochemical outcomes, since currently the proportion of patients achieving complete clinical and biochemical response with MRA is quite low.
publishDate	2025
dc.date.none.fl_str_mv	2025 2025-01-01 2025 2025-01-01
dc.type.none.fl_str_mv	journal article http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/10171/122073
url	https://hdl.handle.net/10171/122073
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	Oxford Academic
publisher.none.fl_str_mv	Oxford Academic
dc.source.none.fl_str_mv	reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra
instname_str	Universidad de Navarra
reponame_str	Dadun. Depósito Académico Digital de la Universidad de Navarra
collection	Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling	Efficacy and safety of medical treatment of primary aldosteronism: a real-world data study in SpainGoi, J. (Jessica)\|\|\|/items/805408b2-cc7b-4a42-96d2-1ff7afb35c4ePaja, M. (Miguel)\|\|\|/items/7363db50-6d05-4cc5-9ce0-7ef843ec77a9Rizo-Gellida, A. (Alicia)\|\|\|/items/f8a92d62-01bb-463e-87e6-0bda3a8280f4González-Boillos, M. (Marga)\|\|\|/items/14f47f15-0a8b-4767-ab55-ea0aded977acMartín-Rojas-Marcos, P. (Patricia)\|\|\|/items/2952c4f1-d2b5-421b-97f7-c957ee865b04Caja-Guayerbas, L. (Laura)\|\|\|/items/5f232a15-5671-4caf-b781-bdf334c309c4García-Cano, A.M. (Ana María)\|\|\|/items/0c1a6ede-96d1-4153-9998-690a803e2b55Ruiz-Sanchez, J.G. (Jorge Gabriel)\|\|\|/items/ef42b270-6a01-45f8-b044-f27c8fb943bdVicente, A. (Almudena)\|\|\|/items/9bcf3945-5ab8-4943-867f-7e938ff96513Gómez-Hoyos, E. (Emilia)\|\|\|/items/3b973185-2531-45e0-b301-01991f8c9b77Recasens, M. (Mónica)\|\|\|/items/b3281727-5780-40f6-ba02-7fa743c22e40Barahona-San-Millan, R. (Rebeca)\|\|\|/items/527db164-4619-4d85-b926-4b6f24c76bbePicón-César, M.J. (María José)\|\|\|/items/cc85f8bd-4d6a-4154-9926-e9d41ed8a29cDíaz-Guardiola, P. (Patricia)\|\|\|/items/958e2021-db10-4964-9ad9-e855e4626ccdPerdomo-Zelaya, C.M. (Carolina María)\|\|\|/items/4197cb06-662e-44da-bef0-348099c09dcdManjón, L. (Laura)\|\|\|/items/d15f30f7-fd73-4d9d-8b50-3f23d8a93c0fRebollo-Román, A. (Angel)\|\|\|/items/c80baf90-012b-4651-8d31-25e1356a0694Robles-Lázaro, C. (Cristina)\|\|\|/items/b1e66a15-6a19-4e31-8597-a43a0cb04746María-Recio, J. (José)\|\|\|/items/51db7c9f-2cb7-489d-b2e1-b87f7dde9004Calatayud, M. (Maria)\|\|\|/items/83518338-0d4a-4487-a5ab-04d2fe03e907Jiménez-López, N. (Noemi)\|\|\|/items/ade06492-a603-4b38-8b8a-ac36c55e4772Sampedro-Nuñez, M.A. (Miguel Antonio)\|\|\|/items/ebe0283a-614e-4b38-a4a2-b136e5f529c4Mena-Ribas, E. (Elena)\|\|\|/items/18ff8f89-b8fc-4fa2-92c9-433cf7945b08Sanmartín-Sánchez, A. (Alicia)\|\|\|/items/0e8b64e5-e76b-4dde-a559-050e69303517Gonzalvo-Diaz, C. (César)\|\|\|/items/bbc4e225-d0fd-46b9-8bc2-030587915a21Llamas-Rey, C. (Cristina)\|\|\|/items/a8ccc2ef-8b0f-4f2c-b7ea-ab12877dadb8Serrano, J. (Joaquín)\|\|\|/items/3978953f-1c47-4457-be86-a0e3d55df432Michalopoulou, T. (Theodora)\|\|\|/items/b4bc510b-e718-471b-b8f3-969c0868de50Tenés-Rodrigo, S. (Susana)\|\|\|/items/c3296936-a3ae-4b15-b255-d8b28bfb3838Pascual-Corrales, E. (Eider)\|\|\|/items/179fc326-5dc6-4a13-83a6-ea53b6cf9a73Jaén-Aguila, F. (Fernando)\|\|\|/items/11cfcb4b-ed3e-448f-a610-211dcf11dd70Muñoz-Rivas, N. (Nuria)\|\|\|/items/bd3efb7d-986d-434c-a0e0-fdbda5ba328dMoya-Mateo, E.M. (Eva María)\|\|\|/items/a2401f21-6f2d-45bb-95f2-df47cfa3a9abGutiérrez-Medina, S. (Sonsoles)\|\|\|/items/2cfa931d-4e41-4c98-9856-dc8b08a87419Hanzu, F. (Felicia)\|\|\|/items/18094f90-5b34-4f9f-a644-84baa14d7612Parra-Ramírez, P. (Paola)\|\|\|/items/5910008e-44ca-41b8-8f82-2bd8fd5c6a23Araujo-Castro, M. (Marta)\|\|\|/items/be343957-0b49-450b-9999-b8687cebeba5primary aldosteronismspironolactoneeplerenonereninaldosteroneObjective This study aims to analyze current medical management of primary aldosteronism (PA) in Spain, including doses, adverse events (AEs), and efficacy. Methods SPAIN-ALDO is a national, multicenter, retrospective registry of patients with PA in Spain. For this study, information about medical treatment with mineralocorticoid receptor antagonist (MRA) as first-line or postsurgical therapy and about antihypertensive medications used before PA targeted treatment (MRA or adrenalectomy) was included. We reported surgically and medically treated patients at baseline and at last available follow-up and evaluated clinical and biochemical responses according to Primary Aldosteronism Surgical Outcome (PASO) and Primary Aldosteronism Medical treatment Outcome (PAMO) criteria. Results A total of 997 patients with PA were included. Before PA diagnosis, the classes of antihypertensive drugs most used were calcium-channel blockers (66%) and angiotensin II receptor blockers (48.4%). Of the initial cohort, 880 patients had at least 1 visit available after initiation of MRA (N = 511 as first-line therapy, N = 47 postsurgery) or adrenalectomy (N = 322). The median defined daily dose of MRA therapy was 1.33. Spironolactone was more prescribed than eplerenone (58% vs 42%). Eplerenone was better tolerated than spironolactone (AEs in 4% vs 18%), particularly among males. After a median follow-up of 35 and 17 months for medically and surgically managed patients, the latter achieved a complete biochemical (68.1%) or clinical (33.6%) response more frequently than people under MRA as first-line therapy (48.6% and 15.7%; P < .001). Conclusion This study underscores the need to optimize PA medical management in Spain to improve patient clinical and biochemical outcomes, since currently the proportion of patients achieving complete clinical and biochemical response with MRA is quite low.Oxford AcademicDadun. Depósito Académico Digital Universidad de Navarra20252025-01-0120252025-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/122073reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/1220732026-06-21T12:47:57Z
score	15,81155

Efficacy and safety of medical treatment of primary aldosteronism: a real-world data study in Spain

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