Evidence of the causal role of human papillomavirus type 58 in an oropharyngeal carcinoma

Persistent human papillomavirus infection (HPV) is recognized as an important etiologic factor for a subset of head and neck squamous cell carcinomas (SCC), especially those arising from the oropharynx. Whereas HPV16 accounts for the majority of HPV DNA-positive oropharyngeal SCC, infections with ot...

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Autores: Baboci, Lorena, Boscolo-Rizzo, Paolo, Holzinger, Dana, Bertorelle, Roberta, Biasini, Lorena, Michel, Angelika, Schmitt, Markus, Spinato, Giacomo, Bussani, Rossana, Alemany i Vilches, Laia, Tirelli, Giancarlo, Mosto, Maria Cristina Da, Mistro, Annarosa Del, Pawlita, Michael
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/126396
Acceso en línea:https://hdl.handle.net/2445/126396
Access Level:acceso abierto
Palabra clave:Papil·lomavirus
Càncer
Papillomaviruses
Cancer
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spelling Evidence of the causal role of human papillomavirus type 58 in an oropharyngeal carcinomaBaboci, LorenaBoscolo-Rizzo, PaoloHolzinger, DanaBertorelle, RobertaBiasini, LorenaMichel, AngelikaSchmitt, MarkusSpinato, GiacomoBussani, RossanaAlemany i Vilches, LaiaTirelli, GiancarloMosto, Maria Cristina DaMistro, Annarosa DelPawlita, MichaelPapil·lomavirusCàncerPapillomavirusesCancerPersistent human papillomavirus infection (HPV) is recognized as an important etiologic factor for a subset of head and neck squamous cell carcinomas (SCC), especially those arising from the oropharynx. Whereas HPV16 accounts for the majority of HPV DNA-positive oropharyngeal SCC, infections with other mucosal high-risk HPV types are quite rare and biological data demonstrating their causal involvement are insufficient. Here we present the first case of an oropharyngeal SCC driven by HPV type 58. A 69-year-old Caucasian woman presented with an enlarged and firm left tonsil. A computed tomography scan showed a left tonsillar mass, extending to the soft palate and the glossotonsillar sulcus. The patient underwent extended radical tonsillectomy and ipsilateral selective neck dissection. Pathology confirmed an infiltrating, poorly differentiated SCC of the left tonsil with node metastasis (pT2N1). Adjuvant external beam radiation therapy (60 Grays (Gy)) was administered. After 1 year of follow-up, the patient is well with no evidence of cancer recurrence. HPV analyses of the tumor tissue by BSGP5+/6+-PCR/MPG, targeting 51 mucosal HPV types, showed single positivity for HPV type 58. Presence of HPV58 E6*I RNA demonstrated biological activity of the virus in the tumor tissue, and presence of serum antibodies to HPV58 oncoproteins E6 and E7 indicated presence of an HPV58-driven cancer. Overexpression of cellular protein p16(INK4a) and reduced expression of pRb, two cellular markers for HPV-induced cell transformation, were observed. Exons 4-10 of TP53 showed no mutations or polymorphisms. The presence of HPV58 as single HPV infection in combination with a broad variety of direct and indirect markers of HPV transformation provides comprehensive evidence that this oropharyngeal SCC was driven by HPV58.BioMed Central Ltd2013info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/126396Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1186/1743-422X-10-334Virology Journal, 2013, vol. 10, num. 334https://doi.org/10.1186/1743-422X-10-334info:eu-repo/grantAgreement/EC/FP7/282562cc by (c) Baboci et al., 2013http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1263962026-05-27T06:46:51Z
dc.title.none.fl_str_mv Evidence of the causal role of human papillomavirus type 58 in an oropharyngeal carcinoma
title Evidence of the causal role of human papillomavirus type 58 in an oropharyngeal carcinoma
spellingShingle Evidence of the causal role of human papillomavirus type 58 in an oropharyngeal carcinoma
Baboci, Lorena
Papil·lomavirus
Càncer
Papillomaviruses
Cancer
title_short Evidence of the causal role of human papillomavirus type 58 in an oropharyngeal carcinoma
title_full Evidence of the causal role of human papillomavirus type 58 in an oropharyngeal carcinoma
title_fullStr Evidence of the causal role of human papillomavirus type 58 in an oropharyngeal carcinoma
title_full_unstemmed Evidence of the causal role of human papillomavirus type 58 in an oropharyngeal carcinoma
title_sort Evidence of the causal role of human papillomavirus type 58 in an oropharyngeal carcinoma
dc.creator.none.fl_str_mv Baboci, Lorena
Boscolo-Rizzo, Paolo
Holzinger, Dana
Bertorelle, Roberta
Biasini, Lorena
Michel, Angelika
Schmitt, Markus
Spinato, Giacomo
Bussani, Rossana
Alemany i Vilches, Laia
Tirelli, Giancarlo
Mosto, Maria Cristina Da
Mistro, Annarosa Del
Pawlita, Michael
author Baboci, Lorena
author_facet Baboci, Lorena
Boscolo-Rizzo, Paolo
Holzinger, Dana
Bertorelle, Roberta
Biasini, Lorena
Michel, Angelika
Schmitt, Markus
Spinato, Giacomo
Bussani, Rossana
Alemany i Vilches, Laia
Tirelli, Giancarlo
Mosto, Maria Cristina Da
Mistro, Annarosa Del
Pawlita, Michael
author_role author
author2 Boscolo-Rizzo, Paolo
Holzinger, Dana
Bertorelle, Roberta
Biasini, Lorena
Michel, Angelika
Schmitt, Markus
Spinato, Giacomo
Bussani, Rossana
Alemany i Vilches, Laia
Tirelli, Giancarlo
Mosto, Maria Cristina Da
Mistro, Annarosa Del
Pawlita, Michael
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Papil·lomavirus
Càncer
Papillomaviruses
Cancer
topic Papil·lomavirus
Càncer
Papillomaviruses
Cancer
description Persistent human papillomavirus infection (HPV) is recognized as an important etiologic factor for a subset of head and neck squamous cell carcinomas (SCC), especially those arising from the oropharynx. Whereas HPV16 accounts for the majority of HPV DNA-positive oropharyngeal SCC, infections with other mucosal high-risk HPV types are quite rare and biological data demonstrating their causal involvement are insufficient. Here we present the first case of an oropharyngeal SCC driven by HPV type 58. A 69-year-old Caucasian woman presented with an enlarged and firm left tonsil. A computed tomography scan showed a left tonsillar mass, extending to the soft palate and the glossotonsillar sulcus. The patient underwent extended radical tonsillectomy and ipsilateral selective neck dissection. Pathology confirmed an infiltrating, poorly differentiated SCC of the left tonsil with node metastasis (pT2N1). Adjuvant external beam radiation therapy (60 Grays (Gy)) was administered. After 1 year of follow-up, the patient is well with no evidence of cancer recurrence. HPV analyses of the tumor tissue by BSGP5+/6+-PCR/MPG, targeting 51 mucosal HPV types, showed single positivity for HPV type 58. Presence of HPV58 E6*I RNA demonstrated biological activity of the virus in the tumor tissue, and presence of serum antibodies to HPV58 oncoproteins E6 and E7 indicated presence of an HPV58-driven cancer. Overexpression of cellular protein p16(INK4a) and reduced expression of pRb, two cellular markers for HPV-induced cell transformation, were observed. Exons 4-10 of TP53 showed no mutations or polymorphisms. The presence of HPV58 as single HPV infection in combination with a broad variety of direct and indirect markers of HPV transformation provides comprehensive evidence that this oropharyngeal SCC was driven by HPV58.
publishDate 2013
dc.date.none.fl_str_mv 2013
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/126396
url https://hdl.handle.net/2445/126396
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1186/1743-422X-10-334
Virology Journal, 2013, vol. 10, num. 334
https://doi.org/10.1186/1743-422X-10-334
info:eu-repo/grantAgreement/EC/FP7/282562
dc.rights.none.fl_str_mv cc by (c) Baboci et al., 2013
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Baboci et al., 2013
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BioMed Central Ltd
publisher.none.fl_str_mv BioMed Central Ltd
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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