Molybdenum-catalyzed deoxygenation of heteroaromatic n-oxides and hydroxides using Pinacol as Reducing Agent

A molybdenum-catalyzed deoxygenationof pyridine N -oxides and N-hydroxybenzotriazoles,as well as other azole N-oxides, has been developedusing pinacol as an environmentally friendly oxo-acceptor. The only by-products are acetone andwater making the process a convenient alternativeto established prot...

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Detalles Bibliográficos
Autores: Rubio Presa, Rubén, Fernández Rodríguez, Manuel A., Pedrosa Sáez, María de los Remedios, Arnáiz García, Francisco Javier, Sanz Díez, Roberto
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2017
País:España
Institución:Universidad de Burgos (UBU)
Repositorio:Repositorio Institucional de la Universidad de Burgos (RIUBU)
OAI Identifier:oai:riubu.ubu.es:10259/4528
Acceso en línea:http://hdl.handle.net/10259/4528
Access Level:acceso abierto
Palabra clave:amine N-oxides
deoxygenation
molyb-denum
microwave heating
N-hydroxybenzotria-zoles
Química orgánica
Chemistry, Organic
Descripción
Sumario:A molybdenum-catalyzed deoxygenationof pyridine N -oxides and N-hydroxybenzotriazoles,as well as other azole N-oxides, has been developedusing pinacol as an environmentally friendly oxo-acceptor. The only by-products are acetone andwater making the process a convenient alternativeto established protocols in terms of waste gener-ation. The reaction is highly chemose lective and avariety of functional groups are tolerated. Theprocesses are usually very clean allowing theisolation of the pure deoxygenated products after asimple extraction in most cases.