The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients

Torres, Antoni; Motos, Anna; Riera, Jordi; Fernández Barat, Laia; Ceccato, Adrián; Pérez Arnal, Raquel; García Gasulla, Darío; Peñuelas, Oscar; Lorente, José Ángel; Rodríguez, Alejandro; de Gonzalo Calvo, David; Almansa, Raquel; Gabarrús, Albert; Menéndez, Rosario; Bermejo Martin, Jesús F.; Ferrer, Ricard; Amaya Villar, Rosario; Añón, José M.; Barberà, Carme; Barberán, José; Blandino Ortiz, Aaron; Bustamante Munguira, Elena; Caballero, Jesús; Carbajales, Cristina; Carbonell, Nieves; Catalán González, Mercedes; Galbán, Cristóbal; Gumucio Sanguino, Víctor D.; de la Torre, Maria del Carmen; Díaz, Emili; Estella, Ángel; Gallego, Elena; García Garmendia, José Luis; Garnacho Montero, José; Gómez, José Manuel; Huerta, Arturo; Jorge García, Ruth Noemí; Loza Vázquez, Ana; Marin Corral, Judith; Martínez de la Gándara, Amalia; Martínez Varela, Ignacio; López Messa, Juan; Albaiceta, Guillermo M.; Novo, Mariana Andrea; Peñasco, Yhivian; Pozo Laderas, Juan Carlos; Ricart, Pilar; Salvador Adell, Inmaculada; Sánchez Miralles, Angel; Sancho Chinesta, Susana; Socias, Lorenzo; Solé Violan, Jordi; Suares Sipmann, Fernando; Tamayo Lomas, Luis; Trenado, José; Barbé Illa, Ferran

The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients

Correcció de l'article publicat a: https://doi.org/10.1186/s13054-021-03849-2

Detalhes bibliográficos
Autores:	Torres, Antoni, Motos, Anna, Riera, Jordi, Fernández Barat, Laia, Ceccato, Adrián, Pérez Arnal, Raquel, García Gasulla, Darío, Peñuelas, Oscar, Lorente, José Ángel, Rodríguez, Alejandro, de Gonzalo Calvo, David, Almansa, Raquel, Gabarrús, Albert, Menéndez, Rosario, Bermejo Martin, Jesús F., Ferrer, Ricard, Amaya Villar, Rosario, Añón, José M., Barberà, Carme, Barberán, José, Blandino Ortiz, Aaron, Bustamante Munguira, Elena, Caballero, Jesús, Carbajales, Cristina, Carbonell, Nieves, Catalán González, Mercedes, Galbán, Cristóbal, Gumucio Sanguino, Víctor D., de la Torre, Maria del Carmen, Díaz, Emili, Estella, Ángel, Gallego, Elena, García Garmendia, José Luis, Garnacho Montero, José, Gómez, José Manuel, Huerta, Arturo, Jorge García, Ruth Noemí, Loza Vázquez, Ana, Marin Corral, Judith, Martínez de la Gándara, Amalia, Martínez Varela, Ignacio, López Messa, Juan, Albaiceta, Guillermo M., Novo, Mariana Andrea, Peñasco, Yhivian, Pozo Laderas, Juan Carlos, Ricart, Pilar, Salvador Adell, Inmaculada, Sánchez Miralles, Angel, Sancho Chinesta, Susana, Socias, Lorenzo, Solé Violan, Jordi, Suares Sipmann, Fernando, Tamayo Lomas, Luis, Trenado, José, Barbé Illa, Ferran
Tipo de documento:	artigo
Estado:	Versão publicada
Data de publicação:	2021
País:	España
Recursos:	Universitat de Lleida (UdL)
Repositório:	Repositori Obert UdL
OAI Identifier:	oai:repositori.udl.cat:10459.1/72712
Acesso em linha:	https://doi.org/10.1186/s13054-021-03727-x http://hdl.handle.net/10459.1/72712
Access Level:	Acceso aberto
Palavra-chave:	COVID-19 Coronavirus Mechanical ventilation SARS-CoV-2 Ventilatory ratio

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spelling	The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patientsTorres, AntoniMotos, AnnaRiera, JordiFernández Barat, LaiaCeccato, AdriánPérez Arnal, RaquelGarcía Gasulla, DaríoPeñuelas, OscarLorente, José ÁngelRodríguez, Alejandrode Gonzalo Calvo, DavidAlmansa, RaquelGabarrús, AlbertMenéndez, RosarioBermejo Martin, Jesús F.Ferrer, RicardAmaya Villar, RosarioAñón, José M.Barberà, CarmeBarberán, JoséBlandino Ortiz, AaronBustamante Munguira, ElenaCaballero, JesúsCarbajales, CristinaCarbonell, NievesCatalán González, MercedesGalbán, CristóbalGumucio Sanguino, Víctor D.de la Torre, Maria del CarmenDíaz, EmiliEstella, ÁngelGallego, ElenaGarcía Garmendia, José LuisGarnacho Montero, JoséGómez, José ManuelHuerta, ArturoJorge García, Ruth NoemíLoza Vázquez, AnaMarin Corral, JudithMartínez de la Gándara, AmaliaMartínez Varela, IgnacioLópez Messa, JuanAlbaiceta, Guillermo M.Novo, Mariana AndreaPeñasco, YhivianPozo Laderas, Juan CarlosRicart, PilarSalvador Adell, InmaculadaSánchez Miralles, AngelSancho Chinesta, SusanaSocias, LorenzoSolé Violan, JordiSuares Sipmann, FernandoTamayo Lomas, LuisTrenado, JoséBarbé Illa, FerranCOVID-19CoronavirusMechanical ventilationSARS-CoV-2Ventilatory ratioCorrecció de l'article publicat a: https://doi.org/10.1186/s13054-021-03849-2Background: Mortality due to COVID-19 is high, especially in patients requiring mechanical ventilation. The purpose of the study is to investigate associations between mortality and variables measured during the first three days of mechanical ventilation in patients with COVID-19 intubated at ICU admission. Methods: Multicenter, observational, cohort study includes consecutive patients with COVID-19 admitted to 44 Spanish ICUs between February 25 and July 31, 2020, who required intubation at ICU admission and mechanical ventilation for more than three days. We collected demographic and clinical data prior to admission; information about clinical evolution at days 1 and 3 of mechanical ventilation; and outcomes. Results: Of the 2,095 patients with COVID-19 admitted to the ICU, 1,118 (53.3%) were intubated at day 1 and remained under mechanical ventilation at day three. From days 1 to 3, PaO2/FiO2 increased from 115.6 [80.0-171.2] to 180.0 [135.4-227.9] mmHg and the ventilatory ratio from 1.73 [1.33-2.25] to 1.96 [1.61-2.40]. In-hospital mortality was 38.7%. A higher increase between ICU admission and day 3 in the ventilatory ratio (OR 1.04 [CI 1.01-1.07], p = 0.030) and creatinine levels (OR 1.05 [CI 1.01-1.09], p = 0.005) and a lower increase in platelet counts (OR 0.96 [CI 0.93-1.00], p = 0.037) were independently associated with a higher risk of death. No association between mortality and the PaO2/FiO2 variation was observed (OR 0.99 [CI 0.95 to 1.02], p = 0.47). Conclusions: Higher ventilatory ratio and its increase at day 3 is associated with mortality in patients with COVID-19 receiving mechanical ventilation at ICU admission. No association was found in the PaO2/FiO2 variation.Financial support was provided by the Instituto de Salud Carlos III de Madrid (COV20/00110, ISCIII), Fondo Europeo de Desarrollo Regional (FEDER), "Una manera de hacer Europa", and by the Centro de Investigación Biomedica En Red – Enfermedades Respiratorias (CIBERES). DdGC has received fnancial support from Instituto de Salud Carlos III (Miguel Servet 2020: CP20/00041), co-funded by European Social Fund (ESF)/”Investing in your future”.BMCInternational Symposium on Intensive Care and Emergency Medicine (ISICEM)Critical Care Canada Forum (CCCF)2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://doi.org/10.1186/s13054-021-03727-xhttp://hdl.handle.net/10459.1/72712reponame:Repositori Obert UdL instname:Universitat de Lleida (UdL)InglésReproducció del document publicat a: https://doi.org/10.1186/s13054-021-03727-xCritical Care, 2021, vol. 25, núm. 331cc-by (c) authors, 2021info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/oai:repositori.udl.cat:10459.1/727122026-06-24T12:42:17Z
dc.title.none.fl_str_mv	The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients
title	The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients
spellingShingle	The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients Torres, Antoni COVID-19 Coronavirus Mechanical ventilation SARS-CoV-2 Ventilatory ratio
title_short	The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients
title_full	The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients
title_fullStr	The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients
title_full_unstemmed	The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients
title_sort	The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients
dc.creator.none.fl_str_mv	Torres, Antoni Motos, Anna Riera, Jordi Fernández Barat, Laia Ceccato, Adrián Pérez Arnal, Raquel García Gasulla, Darío Peñuelas, Oscar Lorente, José Ángel Rodríguez, Alejandro de Gonzalo Calvo, David Almansa, Raquel Gabarrús, Albert Menéndez, Rosario Bermejo Martin, Jesús F. Ferrer, Ricard Amaya Villar, Rosario Añón, José M. Barberà, Carme Barberán, José Blandino Ortiz, Aaron Bustamante Munguira, Elena Caballero, Jesús Carbajales, Cristina Carbonell, Nieves Catalán González, Mercedes Galbán, Cristóbal Gumucio Sanguino, Víctor D. de la Torre, Maria del Carmen Díaz, Emili Estella, Ángel Gallego, Elena García Garmendia, José Luis Garnacho Montero, José Gómez, José Manuel Huerta, Arturo Jorge García, Ruth Noemí Loza Vázquez, Ana Marin Corral, Judith Martínez de la Gándara, Amalia Martínez Varela, Ignacio López Messa, Juan Albaiceta, Guillermo M. Novo, Mariana Andrea Peñasco, Yhivian Pozo Laderas, Juan Carlos Ricart, Pilar Salvador Adell, Inmaculada Sánchez Miralles, Angel Sancho Chinesta, Susana Socias, Lorenzo Solé Violan, Jordi Suares Sipmann, Fernando Tamayo Lomas, Luis Trenado, José Barbé Illa, Ferran
author	Torres, Antoni
author_facet	Torres, Antoni Motos, Anna Riera, Jordi Fernández Barat, Laia Ceccato, Adrián Pérez Arnal, Raquel García Gasulla, Darío Peñuelas, Oscar Lorente, José Ángel Rodríguez, Alejandro de Gonzalo Calvo, David Almansa, Raquel Gabarrús, Albert Menéndez, Rosario Bermejo Martin, Jesús F. Ferrer, Ricard Amaya Villar, Rosario Añón, José M. Barberà, Carme Barberán, José Blandino Ortiz, Aaron Bustamante Munguira, Elena Caballero, Jesús Carbajales, Cristina Carbonell, Nieves Catalán González, Mercedes Galbán, Cristóbal Gumucio Sanguino, Víctor D. de la Torre, Maria del Carmen Díaz, Emili Estella, Ángel Gallego, Elena García Garmendia, José Luis Garnacho Montero, José Gómez, José Manuel Huerta, Arturo Jorge García, Ruth Noemí Loza Vázquez, Ana Marin Corral, Judith Martínez de la Gándara, Amalia Martínez Varela, Ignacio López Messa, Juan Albaiceta, Guillermo M. Novo, Mariana Andrea Peñasco, Yhivian Pozo Laderas, Juan Carlos Ricart, Pilar Salvador Adell, Inmaculada Sánchez Miralles, Angel Sancho Chinesta, Susana Socias, Lorenzo Solé Violan, Jordi Suares Sipmann, Fernando Tamayo Lomas, Luis Trenado, José Barbé Illa, Ferran
author_role	author
author2	Motos, Anna Riera, Jordi Fernández Barat, Laia Ceccato, Adrián Pérez Arnal, Raquel García Gasulla, Darío Peñuelas, Oscar Lorente, José Ángel Rodríguez, Alejandro de Gonzalo Calvo, David Almansa, Raquel Gabarrús, Albert Menéndez, Rosario Bermejo Martin, Jesús F. Ferrer, Ricard Amaya Villar, Rosario Añón, José M. Barberà, Carme Barberán, José Blandino Ortiz, Aaron Bustamante Munguira, Elena Caballero, Jesús Carbajales, Cristina Carbonell, Nieves Catalán González, Mercedes Galbán, Cristóbal Gumucio Sanguino, Víctor D. de la Torre, Maria del Carmen Díaz, Emili Estella, Ángel Gallego, Elena García Garmendia, José Luis Garnacho Montero, José Gómez, José Manuel Huerta, Arturo Jorge García, Ruth Noemí Loza Vázquez, Ana Marin Corral, Judith Martínez de la Gándara, Amalia Martínez Varela, Ignacio López Messa, Juan Albaiceta, Guillermo M. Novo, Mariana Andrea Peñasco, Yhivian Pozo Laderas, Juan Carlos Ricart, Pilar Salvador Adell, Inmaculada Sánchez Miralles, Angel Sancho Chinesta, Susana Socias, Lorenzo Solé Violan, Jordi Suares Sipmann, Fernando Tamayo Lomas, Luis Trenado, José Barbé Illa, Ferran
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	COVID-19 Coronavirus Mechanical ventilation SARS-CoV-2 Ventilatory ratio
topic	COVID-19 Coronavirus Mechanical ventilation SARS-CoV-2 Ventilatory ratio
description	Correcció de l'article publicat a: https://doi.org/10.1186/s13054-021-03849-2
publishDate	2021
dc.date.none.fl_str_mv	2021
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://doi.org/10.1186/s13054-021-03727-x http://hdl.handle.net/10459.1/72712
url	https://doi.org/10.1186/s13054-021-03727-x http://hdl.handle.net/10459.1/72712
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	Reproducció del document publicat a: https://doi.org/10.1186/s13054-021-03727-x Critical Care, 2021, vol. 25, núm. 331
dc.rights.none.fl_str_mv	cc-by (c) authors, 2021 info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/4.0/
rights_invalid_str_mv	cc-by (c) authors, 2021 http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	BMC International Symposium on Intensive Care and Emergency Medicine (ISICEM) Critical Care Canada Forum (CCCF)
publisher.none.fl_str_mv	BMC International Symposium on Intensive Care and Emergency Medicine (ISICEM) Critical Care Canada Forum (CCCF)
dc.source.none.fl_str_mv	reponame:Repositori Obert UdL instname:Universitat de Lleida (UdL)
instname_str	Universitat de Lleida (UdL)
reponame_str	Repositori Obert UdL
collection	Repositori Obert UdL
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15,812455

The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients

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