The Distinctive Features behind the Aggressiveness of Oral and Cutaneous Squamous Cell Carcinomas

Squamous cell carcinomas arise from stratified squamous epithelia. Here, a comparative analysis based on recent studies defining the genetic alterations and composition of the stroma of oral and cutaneous squamous cell carcinomas (OSCC and CSCC, respectively) was performed. Both carcinomas share som...

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Detalhes bibliográficos
Autores: Alonso-Juarranz, Miguel, Mascaraque, Marta, Carrasco, Elisa, Gracia-Cazaña, Tamara, De La Sen, Oscar, Gilaberte, Yolanda, Gonzalez, Salvador, Juarranz, Ángeles, Falahat Noushzady, Farzin
Formato: artículo
Fecha de publicación:2023
País:España
Recursos:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/104461
Acesso em linha:https://hdl.handle.net/20.500.14352/104461
Access Level:acceso abierto
Palavra-chave:616-006.04
Oral squamous cell carcinoma
Cutaneous squamous cell carcinoma
Tumor microenvironment
Cancer-associated fibroblasts
Immune cells
Tertiary lymphoid structures
Cirugía
3207.13 Oncología
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repository_id_str
spelling The Distinctive Features behind the Aggressiveness of Oral and Cutaneous Squamous Cell CarcinomasAlonso-Juarranz, MiguelMascaraque, MartaCarrasco, ElisaGracia-Cazaña, TamaraDe La Sen, OscarGilaberte, YolandaGonzalez, SalvadorJuarranz, ÁngelesFalahat Noushzady, Farzin616-006.04Oral squamous cell carcinomaCutaneous squamous cell carcinomaTumor microenvironmentCancer-associated fibroblastsImmune cellsTertiary lymphoid structuresCirugía3207.13 OncologíaSquamous cell carcinomas arise from stratified squamous epithelia. Here, a comparative analysis based on recent studies defining the genetic alterations and composition of the stroma of oral and cutaneous squamous cell carcinomas (OSCC and CSCC, respectively) was performed. Both carcinomas share some but not all histological and genetic features. This review was focused on how mutations in tumor suppressor genes and protooncogenes cooperate to determine the differentiation, aggressiveness, and metastatic potential of OSCC and CSCC. In fact, driver mutations in tumor suppressor genes are more frequently observed in OSCC than CSCC. These include mutations in TP53 (encoding pP53 protein), CDKN2A (encoding cyclin dependent kinase inhibitor 2A), FAT1 (encoding FAT atypical cadherin 1), and KMT2D (encoding lysine methyltransferase 2D), with the exception of NOTCH (encoding Notch receptor 1), whose mutation frequency is lower in OSCC compared to CSCC. Finally, we describe the differential composition of the tumor microenvironment and how this influences the aggressiveness of each tumor type. Although both OSCC and CSCC tumors are highly infiltrated by immune cells, high levels of tumor-infiltrating lymphocytes (TILs) have been more frequently reported as predictors of better outcomes in OSCC than CSCC. In conclusion, OSCC and CSCC partially share genetic alterations and possess different causal factors triggering their development. The tumor microenvironment plays a key role determining the outcome of the disease.MPDIUniversidad Complutense de Madrid20232023-01-0120232023-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/104461reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)InglésengInstituto de Salud Carlos III http://dx.doi.org/10.13039/501100004587 FIS 070451Instituto de Salud Carlos III http://dx.doi.org/10.13039/501100004587 FIS 10-02721.open accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1044612026-06-02T12:44:21Z
dc.title.none.fl_str_mv The Distinctive Features behind the Aggressiveness of Oral and Cutaneous Squamous Cell Carcinomas
title The Distinctive Features behind the Aggressiveness of Oral and Cutaneous Squamous Cell Carcinomas
spellingShingle The Distinctive Features behind the Aggressiveness of Oral and Cutaneous Squamous Cell Carcinomas
Alonso-Juarranz, Miguel
616-006.04
Oral squamous cell carcinoma
Cutaneous squamous cell carcinoma
Tumor microenvironment
Cancer-associated fibroblasts
Immune cells
Tertiary lymphoid structures
Cirugía
3207.13 Oncología
title_short The Distinctive Features behind the Aggressiveness of Oral and Cutaneous Squamous Cell Carcinomas
title_full The Distinctive Features behind the Aggressiveness of Oral and Cutaneous Squamous Cell Carcinomas
title_fullStr The Distinctive Features behind the Aggressiveness of Oral and Cutaneous Squamous Cell Carcinomas
title_full_unstemmed The Distinctive Features behind the Aggressiveness of Oral and Cutaneous Squamous Cell Carcinomas
title_sort The Distinctive Features behind the Aggressiveness of Oral and Cutaneous Squamous Cell Carcinomas
dc.creator.none.fl_str_mv Alonso-Juarranz, Miguel
Mascaraque, Marta
Carrasco, Elisa
Gracia-Cazaña, Tamara
De La Sen, Oscar
Gilaberte, Yolanda
Gonzalez, Salvador
Juarranz, Ángeles
Falahat Noushzady, Farzin
author Alonso-Juarranz, Miguel
author_facet Alonso-Juarranz, Miguel
Mascaraque, Marta
Carrasco, Elisa
Gracia-Cazaña, Tamara
De La Sen, Oscar
Gilaberte, Yolanda
Gonzalez, Salvador
Juarranz, Ángeles
Falahat Noushzady, Farzin
author_role author
author2 Mascaraque, Marta
Carrasco, Elisa
Gracia-Cazaña, Tamara
De La Sen, Oscar
Gilaberte, Yolanda
Gonzalez, Salvador
Juarranz, Ángeles
Falahat Noushzady, Farzin
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 616-006.04
Oral squamous cell carcinoma
Cutaneous squamous cell carcinoma
Tumor microenvironment
Cancer-associated fibroblasts
Immune cells
Tertiary lymphoid structures
Cirugía
3207.13 Oncología
topic 616-006.04
Oral squamous cell carcinoma
Cutaneous squamous cell carcinoma
Tumor microenvironment
Cancer-associated fibroblasts
Immune cells
Tertiary lymphoid structures
Cirugía
3207.13 Oncología
description Squamous cell carcinomas arise from stratified squamous epithelia. Here, a comparative analysis based on recent studies defining the genetic alterations and composition of the stroma of oral and cutaneous squamous cell carcinomas (OSCC and CSCC, respectively) was performed. Both carcinomas share some but not all histological and genetic features. This review was focused on how mutations in tumor suppressor genes and protooncogenes cooperate to determine the differentiation, aggressiveness, and metastatic potential of OSCC and CSCC. In fact, driver mutations in tumor suppressor genes are more frequently observed in OSCC than CSCC. These include mutations in TP53 (encoding pP53 protein), CDKN2A (encoding cyclin dependent kinase inhibitor 2A), FAT1 (encoding FAT atypical cadherin 1), and KMT2D (encoding lysine methyltransferase 2D), with the exception of NOTCH (encoding Notch receptor 1), whose mutation frequency is lower in OSCC compared to CSCC. Finally, we describe the differential composition of the tumor microenvironment and how this influences the aggressiveness of each tumor type. Although both OSCC and CSCC tumors are highly infiltrated by immune cells, high levels of tumor-infiltrating lymphocytes (TILs) have been more frequently reported as predictors of better outcomes in OSCC than CSCC. In conclusion, OSCC and CSCC partially share genetic alterations and possess different causal factors triggering their development. The tumor microenvironment plays a key role determining the outcome of the disease.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-01-01
2023
2023-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/104461
url https://hdl.handle.net/20.500.14352/104461
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Instituto de Salud Carlos III http://dx.doi.org/10.13039/501100004587 FIS 070451
Instituto de Salud Carlos III http://dx.doi.org/10.13039/501100004587 FIS 10-02721.
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MPDI
publisher.none.fl_str_mv MPDI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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