Whole-brain dynamics in aging: disruptions in functional connectivity and the role of the rich club

Normal aging causes disruptions in the brain that can lead to cognitive decline. Resting-state functional magnetic resonance imaging studies have found significant age-related alterations in functional connectivity across various networks. Nevertheless, most of the studies have focused mainly on sta...

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Autores: Escrichs, Anira, Biarnés, Carles, Garre Olmo, Josep, Fernández Real, Xavier, Ramos, Rafel, Pamplona Gras, Reinald, Brugada, Ramon, Serena, Joaquín, Ramió Torrentà, Lluís, Coll-De-Tuero, Gabriel, Gallart, Luís, Barretina Ginesta, Jordi, Vilanova, Joan Carles, Mayneris Perxachs, Jordi, Essig, Marco, Figley, Chase R., Pedraza, Salvador, Puig, Josep, Deco, Gustavo
Tipo de recurso: artículo
Estado:Versión enviada para evaluación y publicación
Fecha de publicación:2021
País:España
Institución:Universitat de Lleida (UdL)
Repositorio:Repositori Obert UdL
OAI Identifier:oai:repositori.udl.cat:10459.1/72824
Acceso en línea:https://doi.org/10.1093/cercor/bhaa367
http://hdl.handle.net/10459.1/72824
Access Level:acceso abierto
Palabra clave:Aging
Metastability
Rich-club
Resting-state fMRI
Whole-brain dynamics
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spelling Whole-brain dynamics in aging: disruptions in functional connectivity and the role of the rich clubEscrichs, AniraBiarnés, CarlesGarre Olmo, JosepFernández Real, XavierRamos, RafelPamplona Gras, ReinaldBrugada, RamonSerena, JoaquínRamió Torrentà, LluísColl-De-Tuero, GabrielGallart, LuísBarretina Ginesta, JordiVilanova, Joan CarlesMayneris Perxachs, JordiEssig, MarcoFigley, Chase R.Pedraza, SalvadorPuig, JosepDeco, GustavoAgingMetastabilityRich-clubResting-state fMRIWhole-brain dynamicsNormal aging causes disruptions in the brain that can lead to cognitive decline. Resting-state functional magnetic resonance imaging studies have found significant age-related alterations in functional connectivity across various networks. Nevertheless, most of the studies have focused mainly on static functional connectivity. Studying the dynamics of resting-state brain activity across the whole-brain functional network can provide a better characterization of age-related changes. Here, we employed two data-driven whole-brain approaches based on the phase synchronization of blood-oxygen-level-dependent signals to analyze resting-state fMRI data from 620 subjects divided into two groups (middle-age group (n = 310); age range, 50–64 years versus older group (n = 310); age range, 65–91 years). Applying the intrinsic-ignition framework to assess the effect of spontaneous local activation events on local–global integration, we found that the older group showed higher intrinsic ignition across the whole-brain functional network, but lower metastability. Using Leading Eigenvector Dynamics Analysis, we found that the older group showed reduced ability to access a metastable substate that closely overlaps with the so-called rich club. These findings suggest that functional whole-brain dynamics are altered in aging, probably due to a deficiency in a metastable substate that is key for efficient global communication in the brain.A.E. was supported by the Catalan project Imagenoma de L'Envelliment (Aging Imageomics Study). G.D. was supported by the Spanish Ministry of Economy and Competitiveness, Spain (grant agreement number PSI2016- 75688-P, MINECO/AEI/FEDER-EU); European Union's Horizon 2020 FET Flagship Human Brain Project (grant agreement number 785907, HBP SGA2); the Catalan Research Support, Spain (grant agreement number 2017 SGR 1545) and La Marató TV3 2017 (grant agreement 201725.33).Oxford University Press2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/submittedVersionhttps://doi.org/10.1093/cercor/bhaa367http://hdl.handle.net/10459.1/72824reponame:Repositori Obert UdL instname:Universitat de Lleida (UdL)InglésVersió preprint del document publicat a https://doi.org/10.1093/cercor/bhaa367Cerebral Cortex, 2021, vol. 31, núm. 5, p. 2466-2481info:eu-repo/grantAgreement/EC/H2020/785907cc-by-nc-nd (c) Escrichs et al., 2021info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/oai:repositori.udl.cat:10459.1/728242026-06-24T12:42:17Z
dc.title.none.fl_str_mv Whole-brain dynamics in aging: disruptions in functional connectivity and the role of the rich club
title Whole-brain dynamics in aging: disruptions in functional connectivity and the role of the rich club
spellingShingle Whole-brain dynamics in aging: disruptions in functional connectivity and the role of the rich club
Escrichs, Anira
Aging
Metastability
Rich-club
Resting-state fMRI
Whole-brain dynamics
title_short Whole-brain dynamics in aging: disruptions in functional connectivity and the role of the rich club
title_full Whole-brain dynamics in aging: disruptions in functional connectivity and the role of the rich club
title_fullStr Whole-brain dynamics in aging: disruptions in functional connectivity and the role of the rich club
title_full_unstemmed Whole-brain dynamics in aging: disruptions in functional connectivity and the role of the rich club
title_sort Whole-brain dynamics in aging: disruptions in functional connectivity and the role of the rich club
dc.creator.none.fl_str_mv Escrichs, Anira
Biarnés, Carles
Garre Olmo, Josep
Fernández Real, Xavier
Ramos, Rafel
Pamplona Gras, Reinald
Brugada, Ramon
Serena, Joaquín
Ramió Torrentà, Lluís
Coll-De-Tuero, Gabriel
Gallart, Luís
Barretina Ginesta, Jordi
Vilanova, Joan Carles
Mayneris Perxachs, Jordi
Essig, Marco
Figley, Chase R.
Pedraza, Salvador
Puig, Josep
Deco, Gustavo
author Escrichs, Anira
author_facet Escrichs, Anira
Biarnés, Carles
Garre Olmo, Josep
Fernández Real, Xavier
Ramos, Rafel
Pamplona Gras, Reinald
Brugada, Ramon
Serena, Joaquín
Ramió Torrentà, Lluís
Coll-De-Tuero, Gabriel
Gallart, Luís
Barretina Ginesta, Jordi
Vilanova, Joan Carles
Mayneris Perxachs, Jordi
Essig, Marco
Figley, Chase R.
Pedraza, Salvador
Puig, Josep
Deco, Gustavo
author_role author
author2 Biarnés, Carles
Garre Olmo, Josep
Fernández Real, Xavier
Ramos, Rafel
Pamplona Gras, Reinald
Brugada, Ramon
Serena, Joaquín
Ramió Torrentà, Lluís
Coll-De-Tuero, Gabriel
Gallart, Luís
Barretina Ginesta, Jordi
Vilanova, Joan Carles
Mayneris Perxachs, Jordi
Essig, Marco
Figley, Chase R.
Pedraza, Salvador
Puig, Josep
Deco, Gustavo
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Aging
Metastability
Rich-club
Resting-state fMRI
Whole-brain dynamics
topic Aging
Metastability
Rich-club
Resting-state fMRI
Whole-brain dynamics
description Normal aging causes disruptions in the brain that can lead to cognitive decline. Resting-state functional magnetic resonance imaging studies have found significant age-related alterations in functional connectivity across various networks. Nevertheless, most of the studies have focused mainly on static functional connectivity. Studying the dynamics of resting-state brain activity across the whole-brain functional network can provide a better characterization of age-related changes. Here, we employed two data-driven whole-brain approaches based on the phase synchronization of blood-oxygen-level-dependent signals to analyze resting-state fMRI data from 620 subjects divided into two groups (middle-age group (n = 310); age range, 50–64 years versus older group (n = 310); age range, 65–91 years). Applying the intrinsic-ignition framework to assess the effect of spontaneous local activation events on local–global integration, we found that the older group showed higher intrinsic ignition across the whole-brain functional network, but lower metastability. Using Leading Eigenvector Dynamics Analysis, we found that the older group showed reduced ability to access a metastable substate that closely overlaps with the so-called rich club. These findings suggest that functional whole-brain dynamics are altered in aging, probably due to a deficiency in a metastable substate that is key for efficient global communication in the brain.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/submittedVersion
format article
status_str submittedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1093/cercor/bhaa367
http://hdl.handle.net/10459.1/72824
url https://doi.org/10.1093/cercor/bhaa367
http://hdl.handle.net/10459.1/72824
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió preprint del document publicat a https://doi.org/10.1093/cercor/bhaa367
Cerebral Cortex, 2021, vol. 31, núm. 5, p. 2466-2481
info:eu-repo/grantAgreement/EC/H2020/785907
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Escrichs et al., 2021
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
rights_invalid_str_mv cc-by-nc-nd (c) Escrichs et al., 2021
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositori Obert UdL
instname:Universitat de Lleida (UdL)
instname_str Universitat de Lleida (UdL)
reponame_str Repositori Obert UdL
collection Repositori Obert UdL
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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