Subclinical depressive symptoms and continued cannabis use: predictors of negative outcomes in first episode psychosis

BACKGROUND: Although depressive symptoms in first episode psychosis have been associated with cannabis abuse, their influence on the long-term functional course of FEP patients who abuse cannabis is unknown. The aims of the study were to examine the influence of subclinical depressive symptoms on th...

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Autores: González Ortega, Itxaso, Alberich, Susana, Echeburúa, Enrique, Aizpuru, Felipe, Millán, Eduardo, Vieta i Pascual, Eduard, 1963-, Matute, Carlos, González-Pinto, Ana
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/103066
Acceso en línea:https://hdl.handle.net/2445/103066
Access Level:acceso abierto
Palabra clave:Depressió psíquica
Cànnabis
Psicosi
Psicopatologia
Mental depression
Cannabis
Psychoses
Pathological psychology
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spelling Subclinical depressive symptoms and continued cannabis use: predictors of negative outcomes in first episode psychosisGonzález Ortega, ItxasoAlberich, SusanaEcheburúa, EnriqueAizpuru, FelipeMillán, EduardoVieta i Pascual, Eduard, 1963-Matute, CarlosGonzález-Pinto, AnaDepressió psíquicaCànnabisPsicosiPsicopatologiaMental depressionCannabisPsychosesPathological psychologyBACKGROUND: Although depressive symptoms in first episode psychosis have been associated with cannabis abuse, their influence on the long-term functional course of FEP patients who abuse cannabis is unknown. The aims of the study were to examine the influence of subclinical depressive symptoms on the long-term outcome in first episode-psychosis patients who were cannabis users and to assess the influence of these subclinical depressive symptoms on the ability to quit cannabis use. METHODS: 64 FEP patients who were cannabis users at baseline were followed-up for 5 years. Two groups were defined: (a) patients with subclinical depressive symptoms at least once during follow-up (DPG), and (b) patients without subclinical depressive symptoms during follow-up (NDPG). Psychotic symptoms were measured using the Positive and Negative Syndrome Scale (PANSS), depressive symptoms using the Hamilton Depression Rating Scale (HDRS)-17, and psychosocial functioning was assessed using the Global Assessment of Functioning (GAF). A linear mixed-effects model was used to analyze the combined influence of cannabis use and subclinical depressive symptomatology on the clinical outcome. RESULTS: Subclinical depressive symptoms were associated with continued abuse of cannabis during follow-up (β= 4.45; 95% confidence interval [CI]: 1.78 to 11.17; P = .001) and with worse functioning (β = -5.50; 95% CI: -9.02 to -0.33; P = .009). CONCLUSIONS: Subclinical depressive symptoms and continued cannabis abuse during follow-up could be predictors of negative outcomes in FEP patients.Public Library of Science (PLoS)2015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/103066Articles publicats en revistes (Medicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0123707PLoS One, 2015, vol. 10, num. 4, p. e0123707http://dx.doi.org/10.1371/journal.pone.0123707cc-by (c) González Ortega, Itxaso et al., 2015http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1030662026-05-27T06:46:51Z
dc.title.none.fl_str_mv Subclinical depressive symptoms and continued cannabis use: predictors of negative outcomes in first episode psychosis
title Subclinical depressive symptoms and continued cannabis use: predictors of negative outcomes in first episode psychosis
spellingShingle Subclinical depressive symptoms and continued cannabis use: predictors of negative outcomes in first episode psychosis
González Ortega, Itxaso
Depressió psíquica
Cànnabis
Psicosi
Psicopatologia
Mental depression
Cannabis
Psychoses
Pathological psychology
title_short Subclinical depressive symptoms and continued cannabis use: predictors of negative outcomes in first episode psychosis
title_full Subclinical depressive symptoms and continued cannabis use: predictors of negative outcomes in first episode psychosis
title_fullStr Subclinical depressive symptoms and continued cannabis use: predictors of negative outcomes in first episode psychosis
title_full_unstemmed Subclinical depressive symptoms and continued cannabis use: predictors of negative outcomes in first episode psychosis
title_sort Subclinical depressive symptoms and continued cannabis use: predictors of negative outcomes in first episode psychosis
dc.creator.none.fl_str_mv González Ortega, Itxaso
Alberich, Susana
Echeburúa, Enrique
Aizpuru, Felipe
Millán, Eduardo
Vieta i Pascual, Eduard, 1963-
Matute, Carlos
González-Pinto, Ana
author González Ortega, Itxaso
author_facet González Ortega, Itxaso
Alberich, Susana
Echeburúa, Enrique
Aizpuru, Felipe
Millán, Eduardo
Vieta i Pascual, Eduard, 1963-
Matute, Carlos
González-Pinto, Ana
author_role author
author2 Alberich, Susana
Echeburúa, Enrique
Aizpuru, Felipe
Millán, Eduardo
Vieta i Pascual, Eduard, 1963-
Matute, Carlos
González-Pinto, Ana
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Depressió psíquica
Cànnabis
Psicosi
Psicopatologia
Mental depression
Cannabis
Psychoses
Pathological psychology
topic Depressió psíquica
Cànnabis
Psicosi
Psicopatologia
Mental depression
Cannabis
Psychoses
Pathological psychology
description BACKGROUND: Although depressive symptoms in first episode psychosis have been associated with cannabis abuse, their influence on the long-term functional course of FEP patients who abuse cannabis is unknown. The aims of the study were to examine the influence of subclinical depressive symptoms on the long-term outcome in first episode-psychosis patients who were cannabis users and to assess the influence of these subclinical depressive symptoms on the ability to quit cannabis use. METHODS: 64 FEP patients who were cannabis users at baseline were followed-up for 5 years. Two groups were defined: (a) patients with subclinical depressive symptoms at least once during follow-up (DPG), and (b) patients without subclinical depressive symptoms during follow-up (NDPG). Psychotic symptoms were measured using the Positive and Negative Syndrome Scale (PANSS), depressive symptoms using the Hamilton Depression Rating Scale (HDRS)-17, and psychosocial functioning was assessed using the Global Assessment of Functioning (GAF). A linear mixed-effects model was used to analyze the combined influence of cannabis use and subclinical depressive symptomatology on the clinical outcome. RESULTS: Subclinical depressive symptoms were associated with continued abuse of cannabis during follow-up (β= 4.45; 95% confidence interval [CI]: 1.78 to 11.17; P = .001) and with worse functioning (β = -5.50; 95% CI: -9.02 to -0.33; P = .009). CONCLUSIONS: Subclinical depressive symptoms and continued cannabis abuse during follow-up could be predictors of negative outcomes in FEP patients.
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/103066
url https://hdl.handle.net/2445/103066
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0123707
PLoS One, 2015, vol. 10, num. 4, p. e0123707
http://dx.doi.org/10.1371/journal.pone.0123707
dc.rights.none.fl_str_mv cc-by (c) González Ortega, Itxaso et al., 2015
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) González Ortega, Itxaso et al., 2015
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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