Application of the athlete biological passport approach to the detection of growth hormone doping
Context: because of its anabolic and lipolytic properties, growth hormone (GH) use is prohibited in sport. Two methods based on population-derived decision limits are currently used to detect human GH (hGH) abuse: the hGH Biomarkers Test and the Isoforms Differential Immunoassay. Objective: we teste...
| Autores: | , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:10230/54011 |
| Acceso en línea: | http://hdl.handle.net/10230/54011 http://dx.doi.org/10.1210/clinem/dgab799 |
| Access Level: | acceso abierto |
| Palabra clave: | Anti-doping Athlete biological passport Biomarkers Growth hormone |
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Application of the athlete biological passport approach to the detection of growth hormone dopingEquey, TristanPastor, AntonioTorre Fornell, Rafael de laThomas, AndreasGiraud, SylvainThevis, MarioKuuranne, TiiaBaume, NorbertBarroso, OsquelAikin, ReidAnti-dopingAthlete biological passportBiomarkersGrowth hormoneContext: because of its anabolic and lipolytic properties, growth hormone (GH) use is prohibited in sport. Two methods based on population-derived decision limits are currently used to detect human GH (hGH) abuse: the hGH Biomarkers Test and the Isoforms Differential Immunoassay. Objective: we tested the hypothesis that longitudinal profiling of hGH biomarkers through application of the Athlete Biological Passport (ABP) has the potential to flag hGH abuse. Methods: insulin-like growth factor 1 (IGF-1) and procollagen III peptide (P-III-NP) distributions were obtained from 7 years of anti-doping data in elite athletes (n = 11 455) and applied as priors to analyze individual profiles from an hGH administration study in recreational athletes (n = 35). An open-label, randomized, single-site, placebo-controlled administration study was carried out with individuals randomly assigned to 4 arms: placebo, or 3 different doses of recombinant hGH. Serum samples were analyzed for IGF-1, P-III-NP, and hGH isoforms and the performance of a longitudinal, ABP-based approach was evaluated. Results: an ABP-based approach set at a 99% specificity level flagged 20/27 individuals receiving hGH treatment, including 17/27 individuals after cessation of the treatment. ABP sensitivity ranged from 12.5% to 71.4% across the hGH concentrations tested following 7 days of treatment, peaking at 57.1% to 100% after 21 days of treatment, and was maintained between 37.5% and 71.4% for the low and high dose groups 1 week after cessation of treatment. Conclusion: these findings demonstrate that longitudinal profiling of hGH biomarkers can provide suitable performance characteristics for use in anti-doping programs.Oxford University Press20222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/54011http://dx.doi.org/10.1210/clinem/dgab799reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)Inglés© Oxford University Press. This is a pre-copyedited, author-produced version of an article accepted for publication in The Journal of clinical endocrinology and metabolism following peer review. The version of record Equey T, Pastor A, de la Torre Fornell R, Thomas A, Giraud S, Thevis M, et al. Application of the athlete biological passport approach to the detection of growth hormone doping. J Clin Endocrinol Metab. 2022 feb 17; 107(3): 649-59, is available online at: https://academic.oup.com/jcem/article-abstract/107/3/649/6415604?redirectedFrom=fulltext&login=true.info:eu-repo/semantics/openAccessoai:recercat.cat:10230/540112026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Application of the athlete biological passport approach to the detection of growth hormone doping |
| title |
Application of the athlete biological passport approach to the detection of growth hormone doping |
| spellingShingle |
Application of the athlete biological passport approach to the detection of growth hormone doping Equey, Tristan Anti-doping Athlete biological passport Biomarkers Growth hormone |
| title_short |
Application of the athlete biological passport approach to the detection of growth hormone doping |
| title_full |
Application of the athlete biological passport approach to the detection of growth hormone doping |
| title_fullStr |
Application of the athlete biological passport approach to the detection of growth hormone doping |
| title_full_unstemmed |
Application of the athlete biological passport approach to the detection of growth hormone doping |
| title_sort |
Application of the athlete biological passport approach to the detection of growth hormone doping |
| dc.creator.none.fl_str_mv |
Equey, Tristan Pastor, Antonio Torre Fornell, Rafael de la Thomas, Andreas Giraud, Sylvain Thevis, Mario Kuuranne, Tiia Baume, Norbert Barroso, Osquel Aikin, Reid |
| author |
Equey, Tristan |
| author_facet |
Equey, Tristan Pastor, Antonio Torre Fornell, Rafael de la Thomas, Andreas Giraud, Sylvain Thevis, Mario Kuuranne, Tiia Baume, Norbert Barroso, Osquel Aikin, Reid |
| author_role |
author |
| author2 |
Pastor, Antonio Torre Fornell, Rafael de la Thomas, Andreas Giraud, Sylvain Thevis, Mario Kuuranne, Tiia Baume, Norbert Barroso, Osquel Aikin, Reid |
| author2_role |
author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Anti-doping Athlete biological passport Biomarkers Growth hormone |
| topic |
Anti-doping Athlete biological passport Biomarkers Growth hormone |
| description |
Context: because of its anabolic and lipolytic properties, growth hormone (GH) use is prohibited in sport. Two methods based on population-derived decision limits are currently used to detect human GH (hGH) abuse: the hGH Biomarkers Test and the Isoforms Differential Immunoassay. Objective: we tested the hypothesis that longitudinal profiling of hGH biomarkers through application of the Athlete Biological Passport (ABP) has the potential to flag hGH abuse. Methods: insulin-like growth factor 1 (IGF-1) and procollagen III peptide (P-III-NP) distributions were obtained from 7 years of anti-doping data in elite athletes (n = 11 455) and applied as priors to analyze individual profiles from an hGH administration study in recreational athletes (n = 35). An open-label, randomized, single-site, placebo-controlled administration study was carried out with individuals randomly assigned to 4 arms: placebo, or 3 different doses of recombinant hGH. Serum samples were analyzed for IGF-1, P-III-NP, and hGH isoforms and the performance of a longitudinal, ABP-based approach was evaluated. Results: an ABP-based approach set at a 99% specificity level flagged 20/27 individuals receiving hGH treatment, including 17/27 individuals after cessation of the treatment. ABP sensitivity ranged from 12.5% to 71.4% across the hGH concentrations tested following 7 days of treatment, peaking at 57.1% to 100% after 21 days of treatment, and was maintained between 37.5% and 71.4% for the low and high dose groups 1 week after cessation of treatment. Conclusion: these findings demonstrate that longitudinal profiling of hGH biomarkers can provide suitable performance characteristics for use in anti-doping programs. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022 2022 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion |
| format |
article |
| status_str |
acceptedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10230/54011 http://dx.doi.org/10.1210/clinem/dgab799 |
| url |
http://hdl.handle.net/10230/54011 http://dx.doi.org/10.1210/clinem/dgab799 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
Oxford University Press |
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Oxford University Press |
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reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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