Mechanisms Controlling the Expression and Secretion of BDNF

Brain-derived nerve factor (BDNF), through TrkB receptor activation, is an important modulator for many different physiological and pathological functions in the nervous system. Among them, BDNF plays a crucial role in the development and correct maintenance of brain circuits and synaptic plasticity...

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Detalles Bibliográficos
Autores: Arévalo Martín, Juan Carlos, Deogracias, Ruben
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Universidad de Salamanca (USAL)
Repositorio:GREDOS. Repositorio Institucional de la Universidad de Salamanca
OAI Identifier:oai:gredos.usal.es:10366/154856
Acceso en línea:http://hdl.handle.net/10366/154856
Access Level:acceso abierto
Palabra clave:BDNF
proBDNF
Ca2+
expression
nerve cells
neurotrophins
neurotrophin release
secretion
synaptic activity
Neurosecretion
Synaptic Transmission
Brain
2411.12 Fisiología del Sistema Nervioso Central
3205.07 Neurología
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oai_identifier_str oai:gredos.usal.es:10366/154856
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repository_id_str
spelling Mechanisms Controlling the Expression and Secretion of BDNFArévalo Martín, Juan CarlosDeogracias, RubenBDNFproBDNFCa2+expressionnerve cellsneurotrophinsneurotrophin releasesecretionsynaptic activityNeurosecretionSynaptic TransmissionBrain2411.12 Fisiología del Sistema Nervioso Central3205.07 NeurologíaBrain-derived nerve factor (BDNF), through TrkB receptor activation, is an important modulator for many different physiological and pathological functions in the nervous system. Among them, BDNF plays a crucial role in the development and correct maintenance of brain circuits and synaptic plasticity as well as in neurodegenerative diseases. The proper functioning of the central nervous system depends on the available BDNF concentrations, which are tightly regulated at transcriptional and translational levels but also by its regulated secretion. In this review we summarize the new advances regarding the molecular players involved in BDNF release. In addition, we will address how changes of their levels or function in these proteins have a great impact in those functions modulated by BDNF under physiological and pathological conditions.Research in Juan Carlos Arévalo’s and Rubén Deogracias’ laboratories was funded by MCIN/AEI/10.13039/501100011033, grant numbers PID2020-113130RB-100 to JCA, RYC2018-025215- I and PID2020-113086RB-100 to RD.202420242023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10366/154856reponame:GREDOS. Repositorio Institucional de la Universidad de Salamancainstname:Universidad de Salamanca (USAL)Inglésinfo:eu-repo/semantics/openAccessoai:gredos.usal.es:10366/1548562026-06-07T06:28:51Z
dc.title.none.fl_str_mv Mechanisms Controlling the Expression and Secretion of BDNF
title Mechanisms Controlling the Expression and Secretion of BDNF
spellingShingle Mechanisms Controlling the Expression and Secretion of BDNF
Arévalo Martín, Juan Carlos
BDNF
proBDNF
Ca2+
expression
nerve cells
neurotrophins
neurotrophin release
secretion
synaptic activity
Neurosecretion
Synaptic Transmission
Brain
2411.12 Fisiología del Sistema Nervioso Central
3205.07 Neurología
title_short Mechanisms Controlling the Expression and Secretion of BDNF
title_full Mechanisms Controlling the Expression and Secretion of BDNF
title_fullStr Mechanisms Controlling the Expression and Secretion of BDNF
title_full_unstemmed Mechanisms Controlling the Expression and Secretion of BDNF
title_sort Mechanisms Controlling the Expression and Secretion of BDNF
dc.creator.none.fl_str_mv Arévalo Martín, Juan Carlos
Deogracias, Ruben
author Arévalo Martín, Juan Carlos
author_facet Arévalo Martín, Juan Carlos
Deogracias, Ruben
author_role author
author2 Deogracias, Ruben
author2_role author
dc.subject.none.fl_str_mv BDNF
proBDNF
Ca2+
expression
nerve cells
neurotrophins
neurotrophin release
secretion
synaptic activity
Neurosecretion
Synaptic Transmission
Brain
2411.12 Fisiología del Sistema Nervioso Central
3205.07 Neurología
topic BDNF
proBDNF
Ca2+
expression
nerve cells
neurotrophins
neurotrophin release
secretion
synaptic activity
Neurosecretion
Synaptic Transmission
Brain
2411.12 Fisiología del Sistema Nervioso Central
3205.07 Neurología
description Brain-derived nerve factor (BDNF), through TrkB receptor activation, is an important modulator for many different physiological and pathological functions in the nervous system. Among them, BDNF plays a crucial role in the development and correct maintenance of brain circuits and synaptic plasticity as well as in neurodegenerative diseases. The proper functioning of the central nervous system depends on the available BDNF concentrations, which are tightly regulated at transcriptional and translational levels but also by its regulated secretion. In this review we summarize the new advances regarding the molecular players involved in BDNF release. In addition, we will address how changes of their levels or function in these proteins have a great impact in those functions modulated by BDNF under physiological and pathological conditions.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10366/154856
url http://hdl.handle.net/10366/154856
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:GREDOS. Repositorio Institucional de la Universidad de Salamanca
instname:Universidad de Salamanca (USAL)
instname_str Universidad de Salamanca (USAL)
reponame_str GREDOS. Repositorio Institucional de la Universidad de Salamanca
collection GREDOS. Repositorio Institucional de la Universidad de Salamanca
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301603

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