Chronic intermittent hypoxia induces early-stage metabolic dysfunction independently of adipose tissue deregulation

© 2021 by the authors.

Detalles Bibliográficos
Autores: Martins, Fatima O., Sacramento, Joana F., Olea, Elena, Melo, Bernardete F., Prieto-Lloret, Jesús, Obeso, Ana, Rocher, Asunción, Matafome, Paulo, Monteiro, Emilia C., Conde, Silvia V.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/260712
Acceso en línea:http://hdl.handle.net/10261/260712
Access Level:acceso abierto
Palabra clave:Obstructive sleep apnea
Metabolic dysfunction
Insulin resistance
Adipose tissue
Hypoxia
Inflammation
Oxidative stress
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spelling Chronic intermittent hypoxia induces early-stage metabolic dysfunction independently of adipose tissue deregulationMartins, Fatima O.Sacramento, Joana F.Olea, ElenaMelo, Bernardete F.Prieto-Lloret, JesúsObeso, AnaRocher, AsunciónMatafome, PauloMonteiro, Emilia C.Conde, Silvia V.Obstructive sleep apneaMetabolic dysfunctionInsulin resistanceAdipose tissueHypoxiaInflammationOxidative stress© 2021 by the authors.Several studies demonstrated a link between obstructive sleep apnea (OSA) and the development of insulin resistance. However, the main event triggering insulin resistance in OSA remains to be clarified. Herein, we investigated the effect of mild and severe chronic intermittent hypoxia (CIH) on whole-body metabolic deregulation and visceral adipose tissue dysfunction. Moreover, we studied the contribution of obesity to CIH-induced dysmetabolic states. Experiments were performed in male Wistar rats submitted to a control and high-fat (HF) diet. Two CIH protocols were tested: A mild CIH paradigm (5/6 hypoxic (5% O2) cycles/h, 10.5 h/day) during 35 days and a severe CIH paradigm (30 hypoxic (5% O2) cycles, 8 h/day) during 15 days. Fasting glycemia, insulinemia, insulin sensitivity, weight, and fat mass were assessed. Adipose tissue hypoxia, inflammation, angiogenesis, oxidative stress, and metabolism were investigated. Mild and severe CIH increased insulin levels and induced whole-body insulin resistance in control animals, effects not associated with weight gain. In control animals, CIH did not modify adipocytes perimeter as well as adipose tissue hypoxia, angiogenesis, inflammation or oxidative stress. In HF animals, severe CIH attenuated the increase in adipocytes perimeter, adipose tissue hypoxia, angiogenesis, and dysmetabolism. In conclusion, adipose tissue dysfunction is not the main trigger for initial dysmetabolism in CIH. CIH in an early stage might have a protective role against the deleterious effects of HF diet on adipose tissue metabolism.The present study was supported by grant reference BFU2015-70616-R (MINECO/FEDER; DGICYT), and VA106G18 (JCyL), Spain and by the Portuguese Foundation for Science and Technology with contracts for Fátima O. Martins (CEECIND/04266/2017) and Joana F. Sacramento (CEEC IND/02428/2018) and a PhD Grant for Bernardete F. Melo (PD/BD/128336/2017).Multidisciplinary Digital Publishing InstituteMinisterio de Economía y Competitividad (España)Fundação para a Ciência e a Tecnologia (Portugal)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2022202220212022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/260712reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO//BFU2015-70616-Rhttp://dx.doi.org/10.3390/antiox10081233Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2607122026-05-22T06:33:51Z
dc.title.none.fl_str_mv Chronic intermittent hypoxia induces early-stage metabolic dysfunction independently of adipose tissue deregulation
title Chronic intermittent hypoxia induces early-stage metabolic dysfunction independently of adipose tissue deregulation
spellingShingle Chronic intermittent hypoxia induces early-stage metabolic dysfunction independently of adipose tissue deregulation
Martins, Fatima O.
Obstructive sleep apnea
Metabolic dysfunction
Insulin resistance
Adipose tissue
Hypoxia
Inflammation
Oxidative stress
title_short Chronic intermittent hypoxia induces early-stage metabolic dysfunction independently of adipose tissue deregulation
title_full Chronic intermittent hypoxia induces early-stage metabolic dysfunction independently of adipose tissue deregulation
title_fullStr Chronic intermittent hypoxia induces early-stage metabolic dysfunction independently of adipose tissue deregulation
title_full_unstemmed Chronic intermittent hypoxia induces early-stage metabolic dysfunction independently of adipose tissue deregulation
title_sort Chronic intermittent hypoxia induces early-stage metabolic dysfunction independently of adipose tissue deregulation
dc.creator.none.fl_str_mv Martins, Fatima O.
Sacramento, Joana F.
Olea, Elena
Melo, Bernardete F.
Prieto-Lloret, Jesús
Obeso, Ana
Rocher, Asunción
Matafome, Paulo
Monteiro, Emilia C.
Conde, Silvia V.
author Martins, Fatima O.
author_facet Martins, Fatima O.
Sacramento, Joana F.
Olea, Elena
Melo, Bernardete F.
Prieto-Lloret, Jesús
Obeso, Ana
Rocher, Asunción
Matafome, Paulo
Monteiro, Emilia C.
Conde, Silvia V.
author_role author
author2 Sacramento, Joana F.
Olea, Elena
Melo, Bernardete F.
Prieto-Lloret, Jesús
Obeso, Ana
Rocher, Asunción
Matafome, Paulo
Monteiro, Emilia C.
Conde, Silvia V.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Fundação para a Ciência e a Tecnologia (Portugal)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Obstructive sleep apnea
Metabolic dysfunction
Insulin resistance
Adipose tissue
Hypoxia
Inflammation
Oxidative stress
topic Obstructive sleep apnea
Metabolic dysfunction
Insulin resistance
Adipose tissue
Hypoxia
Inflammation
Oxidative stress
description © 2021 by the authors.
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/260712
url http://hdl.handle.net/10261/260712
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO//BFU2015-70616-R
http://dx.doi.org/10.3390/antiox10081233
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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