Repeated pancreatic resection for pancreatic metastases from renal cell Carcinoma: A Spanish multicenter study (PANMEKID)

Background and objectives: Recurrent isolated pancreatic metastasis from Renal Cell Carcinoma (RCC) after pancreatic resection is rare. The purpose of our study is to describe a series of cases of relapse of pancreatic metastasis from renal cancer in the pancreatic remnant and its surgical treatment...

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Detalhes bibliográficos
Autores: Rojas Holguín, Adela, Fondevila Campo, Constantino, Sanjuanbenito, Alfonso, Fabregat Prous, Joan, Secanella Medayo, Luis, Rotellar Sastre, Fernando, Pardo Sánchez, Fernando, Prieto Calvo, Mikel, Marín Ortega, Héctor, Sánchez Cabús, Santiago, Diez Valladares, Luis, Alonso Casado, Óscar, González Serrano, Carmen, Rodríguez Sanjuan, Juan Carlos, García Plaza, Gabriel, Jaén Torrejimeno, Isabel, Suárez Muñoz, Miguel Ángel, Becerra Massare, Antonio, Senra-del Rio, Paula, Pando, Elizabeth, López Andújar, Rafael, Muñoz Forner, Elena, Rodríguez López, Mario, Pereira, Fernando, Serrablo Requejo, Alejandro, Sánchez Turrión, Víctor, Jiménez Garrido, Manuel, Burdío, Fernando, Martín Pérez, Elena, Estevan Estevan, Rafael, López Guerra, Diego, Castell Gómez, José, Salinas Gómez, Javier, López Baena, José Ángel, López Ben, Santiago, Solar García, Lorena, Pérez Alonso, Alejandro J., Martínez Insfran, Luis Alberto, Blas, Juan Luis, Cornejo, Marian, Gutiérrez Calvo, Alberto, Domingo del Pozo, Carlos, Ochando Cerdán, Federico, Muñoz Bellvís, Luis, Rebollar Sáenz, José, Sánchez, Belinda, Jover, José María, Gómez Bravo, Miguel Ángel, Ramia, José Miguel, Blanco Fernández, Gerardo
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Recursos:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/214028
Acesso em linha:https://hdl.handle.net/2445/214028
Access Level:acceso abierto
Palavra-chave:Càncer de pàncrees
Càncer de ronyó
Pancreas cancer
Renal cancer
Descrição
Resumo:Background and objectives: Recurrent isolated pancreatic metastasis from Renal Cell Carcinoma (RCC) after pancreatic resection is rare. The purpose of our study is to describe a series of cases of relapse of pancreatic metastasis from renal cancer in the pancreatic remnant and its surgical treatment with a repeated pancreatic resection, and to analyse the results of both overall and disease -free survival. Methods: Multicenter retrospective study of patients undergoing pancreatic resection for RCC pancreatic metastases, from January 2010 to May 2020. Patients were grouped into two groups depending on whether they received a single pancreatic resection (SPS) or iterative pancreatic resection. Data on short and long-term outcome after pancreatic resection were collected. Results: The study included 131 pancreatic resections performed in 116 patients. Thus, iterative pancreatic surgery (IPS) was performed in 15 patients. The mean length of time between the first pancreatic surgery and the second was 48.9 months (95 % CI: 22.2-56.9). There were no differences in the rate of postoperative complications. The DFS rates at 1, 3 and 5 years were 86 %, 78 % and 78 % vs 75 %, 50 % and 37 % in the IPS and SPS group respectively (p = 0.179). OS rates at 1, 3, 5 and 7 years were 100 %, 100 %, 100 % and 75 % in the IPS group vs 95 %, 85 %, 80 % and 68 % in the SPS group (p = 0.895). Conclusion: Repeated pancreatic resection in case of relapse of pancreatic metastasis of RCC in the pancreatic remnant is justified, since it achieves OS results similar to those obtained after the first resection.

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