Global, regional, and national sepsis and infectious syndrome incidence and mortality, 1990–2021: analysis for the Global Burden of Disease Study

The global burden of sepsis, a life-threatening dysregulated host response to infection leading to organ dysfunction, remains challenging to quantify. We aimed to comprehensively estimate the global, regional, and national burden of sepsis, including the impact of the COVID-19 pandemic and underlyin...

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Autores: Gray, Authia P., Rsu, Rebecca L., Araki, Daniel T., Gershberg Hayoon, Anna, Weaver, Nicole Davis, Swetschinski, Lucien R., Wool, Eve E., Han, Chieh, Villafañe, Jorge Hugo, Et. al.
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universidad Europea (UEM)
Repositorio:ABACUS. Repositorio de Producción Científica
Idioma:inglés
OAI Identifier:oai:abacus.universidadeuropea.com:11268/16412
Acceso en línea:https://hdl.handle.net/11268/16412
Access Level:acceso abierto
Palabra clave:Sepsis
Incidencia
Registros de mortalidad
Estadísticas sanitarias
Enfermedad
Goal 3: Ensure healthy lives and promote well-being for all at all ages
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spelling Global, regional, and national sepsis and infectious syndrome incidence and mortality, 1990–2021: analysis for the Global Burden of Disease StudyGray, Authia P.Rsu, Rebecca L.Araki, Daniel T.Gershberg Hayoon, AnnaWeaver, Nicole DavisSwetschinski, Lucien R.Wool, Eve E.Han, ChiehVillafañe, Jorge HugoEt. al.SepsisIncidenciaRegistros de mortalidadEstadísticas sanitariasEnfermedadGoal 3: Ensure healthy lives and promote well-being for all at all agesThe global burden of sepsis, a life-threatening dysregulated host response to infection leading to organ dysfunction, remains challenging to quantify. We aimed to comprehensively estimate the global, regional, and national burden of sepsis, including the impact of the COVID-19 pandemic and underlying causes of sepsis-related deaths with co-occurring infectious syndromes. We used multiple cause-of-death, hospital, minimally invasive tissue sampling, and linked death certificate and hospital record data representing 149 million deaths, covering 4290 location-years with mortality estimates from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 to capture explicit and implicit sepsis cases and deaths. We estimated age-location-sex-specific fractions of sepsis-related deaths from 195 underlying causes of death and 22 infectious syndromes from 1990 to 2021 using binomial logistic regression models, and estimated sepsis-related deaths using GBD cause-specific mortality estimates. Using 250 million hospital admissions and 7·82 million deaths from hospital data, representing 1310 location-years, we modelled case fatality rates by use of binomial logistic regression, applied to sepsis death estimates to estimate sepsis incidence by age, location, and year.20252025-10-2220252025-01-0120252025-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://hdl.handle.net/11268/16412reponame:ABACUS. Repositorio de Producción Científicainstname:Universidad Europea (UEM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución/Reconocimiento 4.0 Internacionalhttps://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:abacus.universidadeuropea.com:11268/164122026-06-11T12:41:27Z
dc.title.none.fl_str_mv Global, regional, and national sepsis and infectious syndrome incidence and mortality, 1990–2021: analysis for the Global Burden of Disease Study
title Global, regional, and national sepsis and infectious syndrome incidence and mortality, 1990–2021: analysis for the Global Burden of Disease Study
spellingShingle Global, regional, and national sepsis and infectious syndrome incidence and mortality, 1990–2021: analysis for the Global Burden of Disease Study
Gray, Authia P.
Sepsis
Incidencia
Registros de mortalidad
Estadísticas sanitarias
Enfermedad
Goal 3: Ensure healthy lives and promote well-being for all at all ages
title_short Global, regional, and national sepsis and infectious syndrome incidence and mortality, 1990–2021: analysis for the Global Burden of Disease Study
title_full Global, regional, and national sepsis and infectious syndrome incidence and mortality, 1990–2021: analysis for the Global Burden of Disease Study
title_fullStr Global, regional, and national sepsis and infectious syndrome incidence and mortality, 1990–2021: analysis for the Global Burden of Disease Study
title_full_unstemmed Global, regional, and national sepsis and infectious syndrome incidence and mortality, 1990–2021: analysis for the Global Burden of Disease Study
title_sort Global, regional, and national sepsis and infectious syndrome incidence and mortality, 1990–2021: analysis for the Global Burden of Disease Study
dc.creator.none.fl_str_mv Gray, Authia P.
Rsu, Rebecca L.
Araki, Daniel T.
Gershberg Hayoon, Anna
Weaver, Nicole Davis
Swetschinski, Lucien R.
Wool, Eve E.
Han, Chieh
Villafañe, Jorge Hugo
Et. al.
author Gray, Authia P.
author_facet Gray, Authia P.
Rsu, Rebecca L.
Araki, Daniel T.
Gershberg Hayoon, Anna
Weaver, Nicole Davis
Swetschinski, Lucien R.
Wool, Eve E.
Han, Chieh
Villafañe, Jorge Hugo
Et. al.
author_role author
author2 Rsu, Rebecca L.
Araki, Daniel T.
Gershberg Hayoon, Anna
Weaver, Nicole Davis
Swetschinski, Lucien R.
Wool, Eve E.
Han, Chieh
Villafañe, Jorge Hugo
Et. al.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Sepsis
Incidencia
Registros de mortalidad
Estadísticas sanitarias
Enfermedad
Goal 3: Ensure healthy lives and promote well-being for all at all ages
topic Sepsis
Incidencia
Registros de mortalidad
Estadísticas sanitarias
Enfermedad
Goal 3: Ensure healthy lives and promote well-being for all at all ages
description The global burden of sepsis, a life-threatening dysregulated host response to infection leading to organ dysfunction, remains challenging to quantify. We aimed to comprehensively estimate the global, regional, and national burden of sepsis, including the impact of the COVID-19 pandemic and underlying causes of sepsis-related deaths with co-occurring infectious syndromes. We used multiple cause-of-death, hospital, minimally invasive tissue sampling, and linked death certificate and hospital record data representing 149 million deaths, covering 4290 location-years with mortality estimates from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 to capture explicit and implicit sepsis cases and deaths. We estimated age-location-sex-specific fractions of sepsis-related deaths from 195 underlying causes of death and 22 infectious syndromes from 1990 to 2021 using binomial logistic regression models, and estimated sepsis-related deaths using GBD cause-specific mortality estimates. Using 250 million hospital admissions and 7·82 million deaths from hospital data, representing 1310 location-years, we modelled case fatality rates by use of binomial logistic regression, applied to sepsis death estimates to estimate sepsis incidence by age, location, and year.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025-10-22
2025
2025-01-01
2025
2025-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/11268/16412
url https://hdl.handle.net/11268/16412
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución/Reconocimiento 4.0 Internacional
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución/Reconocimiento 4.0 Internacional
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.source.none.fl_str_mv reponame:ABACUS. Repositorio de Producción Científica
instname:Universidad Europea (UEM)
instname_str Universidad Europea (UEM)
reponame_str ABACUS. Repositorio de Producción Científica
collection ABACUS. Repositorio de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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